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Heterotrimeric G proteins; Regulator of G protein signalling proteins (RGS proteins); Gi/o-Loco interacting motif (GoLoco motif); GTPase accelerating proteins (GAPs); Guanine nucleotide dissociation inhibitors (GDIs); Protein-protein interaction
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Regulation Of G Protein Signaling By Goloco Motif Containing Proteins, Peishen Zhao
Regulation Of G Protein Signaling By Goloco Motif Containing Proteins, Peishen Zhao
Electronic Thesis and Dissertation Repository
Signal transduction via heterotrimeric G proteins in response to transmembrane G protein-coupled receptors plays a central aspect in how cells integrate extracellular stimuli and produce biological responses. In addition to receptor-mediated activation of heterotrimeric G proteins, during the last few decades, accessory proteins have been found to regulate G protein activity via different mechanisms. Several proteins have been identified that contain multiple G protein regulatory domains. Using various molecular and biochemical approaches, we have characterized the effects of two such proteins, G18 and RGS14, on G protein activity. Both proteins contain a second G protein binding domain in addition to …