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Full-Text Articles in Molecular Biology

Genetic Diversity Of Easter Island (Rapanui) Population From Identifiler® Plus Autosomal, Y-Filer®, And Y-Plex™ 6 Y-Str Loci, Laura Guadian B.S. May 2015

Genetic Diversity Of Easter Island (Rapanui) Population From Identifiler® Plus Autosomal, Y-Filer®, And Y-Plex™ 6 Y-Str Loci, Laura Guadian B.S.

Theses and Dissertations

This study investigated the genetic diversity of the Easter Island (Rapanui) population using data on 15 autosomal Short Tandem Repeats (STRs) typed with the commercial STR kits Identifiler® Plus and 23 Y-chromosome STRs typed using Y-filer (17 loci) and Y- PLEX™ 6 (6 loci). The analysis was conducted using genotype and haplotype data of 122 presumably unrelated individuals that included 48 males and 74 females. This study: (i) examined if Easter Island population had reduced genetic diversity in comparison with cosmopolitan populations such as Mainland Chilean, Polynesian, European, and African; (ii) compared genetic affinity of the Easter Island population with ...


Analysis Of Yeast Genes Influencing The Lethality Of Dna Damage Related Checkpoint Mutants, Eunmi Kim May 2009

Analysis Of Yeast Genes Influencing The Lethality Of Dna Damage Related Checkpoint Mutants, Eunmi Kim

Theses and Dissertations

The purpose of this study was to determine the functions of Hug1 and Srl3. It has been reported that HUG1 or SRL3 deletion rescues the lethality of a DNA damage checkpoint gene deleted mutant, mec1Δ. It is known that the lethality of mec1Δ can be rescued by high dNTP levels. To elucidate the functions of these proteins, the phenotypes of hug1Δ and srl3Δuvs, as well as the transcript profile of hug1Δ were analyzed. Novel phenotypes of hug1Δ were uncovered: resistance to oxidative stress or heat shock, earlier arrest in G1/G0 phase, defect in hydroxyurea-induced filamentation, and slow growth inresponse ...