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Full-Text Articles in Molecular Biology
Discovering Novel Hearing Loss Genes: Roles For Esrp1 And Gas2 In Inner Ear Development And Auditory Function, Alex Martin Rohacek
Publicly Accessible Penn Dissertations
Hearing loss is the most common form of congenital birth defect, affecting an estimated
35 million children worldwide. To date, nearly 100 genes have been identified which
contribute to a deafness phenotype in humans, however, many cases remain in which a
causative mutation has yet to be found. In addition, the exact mechanism by which
hearing loss occurs in the presence of many of these mutations is still not understood.
This is due, in part, to the complex nature of the development and function of the
cochlear duct, the organ of hearing. The cochlea undergoes an intricate morphogenetic
development and ...