Open Access. Powered by Scholars. Published by Universities.®

Molecular Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Developmental Biology

University of Massachusetts Medical School

Myogenesis

Articles 1 - 2 of 2

Full-Text Articles in Molecular Biology

Differential Expression Of Zinc Transporters Accompanies The Differentiation Of C2c12 Myoblasts, Amanda L. Paskavitz, Julia Quintana, Daniella Cangussu, Cristina Tavera-Montanez, Yao Xiao, Sonia Ortiz-Mirnada, Juan G. Navea, Teresita Padilla-Benavides Sep 2018

Differential Expression Of Zinc Transporters Accompanies The Differentiation Of C2c12 Myoblasts, Amanda L. Paskavitz, Julia Quintana, Daniella Cangussu, Cristina Tavera-Montanez, Yao Xiao, Sonia Ortiz-Mirnada, Juan G. Navea, Teresita Padilla-Benavides

Open Access Articles

Zinc transporters facilitate metal mobilization and compartmentalization, playing a key role in cellular development. Little is known about the mechanisms and pathways of Zn movement between Zn transporters and metalloproteins during myoblast differentiation. We analyzed the differential expression of ZIP and ZnT transporters during C2C12 myoblast differentiation. Zn transporters account for a transient decrease of intracellular Zn upon myogenesis induction followed by a gradual increase of Zn in myotubes. Considering the subcellular localization and function of each of the Zn transporters, our findings indicate that a fine regulation is necessary to maintain correct metal concentrations in the cytosol and subcellular ...


Temporal Regulation Of Chromatin During Myoblast Differentiation, Akihito Harada, Yasuyuki Ohkawa, Anthony N. Imbalzano Dec 2017

Temporal Regulation Of Chromatin During Myoblast Differentiation, Akihito Harada, Yasuyuki Ohkawa, Anthony N. Imbalzano

UMass Metabolic Network Publications

The commitment to and execution of differentiation programmes involves a significant change in gene expression in the precursor cell to facilitate development of the mature cell type. In addition to being regulated by lineage-determining and auxiliary transcription factors that drive these changes, the structural status of the chromatin has a considerable impact on the transcriptional competence of differentiation-specific genes, which is clearly demonstrated by the large number of cofactors and the extraordinary complex mechanisms by which these genes become activated. The terminal differentiation of myoblasts to myotubes and mature skeletal muscle is an excellent system to illustrate these points. The ...