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Molecular Biology Commons

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Developmental Biology

University of Massachusetts Medical School

Program in Gene Function and Expression Publications and Presentations

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Full-Text Articles in Molecular Biology

Targeted Germ Line Disruptions Reveal General And Species-Specific Roles For Paralog Group 1 Hox Genes In Zebrafish, Steven E. Weicksel, Ankit Gupta, Denise A. Zannino, Scot A. Wolfe, Charles G. Sagerstrom Jun 2014

Targeted Germ Line Disruptions Reveal General And Species-Specific Roles For Paralog Group 1 Hox Genes In Zebrafish, Steven E. Weicksel, Ankit Gupta, Denise A. Zannino, Scot A. Wolfe, Charles G. Sagerstrom

Program in Gene Function and Expression Publications and Presentations

BACKGROUND: The developing vertebrate hindbrain is transiently segmented into rhombomeres by a process requiring Hox activity. Hox genes control specification of rhombomere fates, as well as the stereotypic differentiation of rhombomere-specific neuronal populations. Accordingly, germ line disruption of the paralog group 1 (PG1) Hox genes Hoxa1 and Hoxb1 causes defects in hindbrain segmentation and neuron formation in mice. However, antisense-mediated interference with zebrafish hoxb1a and hoxb1b (analogous to murine Hoxb1 and Hoxa1, respectively) produces phenotypes that are qualitatively and quantitatively distinct from those observed in the mouse. This suggests that PG1 Hox genes may have species-specific functions, or that anti-sense ...