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Phospholipase D-Dependent Mtorc1 Activation By Glutamine, Elyssa Bernfeld
Phospholipase D-Dependent Mtorc1 Activation By Glutamine, Elyssa Bernfeld
Dissertations, Theses, and Capstone Projects
Glutamine, the conditionally essential amino acid and most abundant amino acid in human sera, is a key nutrient required for sustaining cell proliferation. Glutamine is essential for nucleotide, protein, and lipid synthesis, all of which are essential for cell proliferation. The mammalian target of rapamycin complex 1 (mTORC1) is a highly conserved protein complex that acts as a sensor of nutrients, relaying signals for the shift from catabolic to anabolic metabolism. While glutamine plays an important role in activating mTORC1, the mechanism is not completely clear. Here we describe a Rag-independent mechanism of mTORC1 activation by glutamine that is dependent …