Biochemistry, Biophysics, and Structural Biology Commons^™

A Tale Of Two Mechanisms: Is The P53 Modulator Coti-2 A Zinc Chaperone Instead?, Irem Simsek

Electronic Theses and Dissertations

The tumor protein p53 plays a vital role in regulating protein pathways that determine the fate of cells. Any interference with p53 function can cause disruptive cell proliferation and carcinogenesis. The p53 protein experiences a high frequency of mutation in human cancers, leading to significant research efforts to target mutant p53 and restore the normal functioning of p53. The COTI-2 small molecule, developed by COTINGA Pharmaceuticals through a computational program, has entered Phase I clinical trials. Although the mechanism of action is not fully understood, it has shown considerable promise in targeting cell lines with mutant p53. COTI-2 is believed …