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Single Molecule Investigations Of Holliday Junction Binding Protein Ruva, Dalton Reed Gibbs
Single Molecule Investigations Of Holliday Junction Binding Protein Ruva, Dalton Reed Gibbs
Theses and Dissertations
DNA breaks are inevitable as they mainly occur due to cells’ own reactive oxygen species (ROS). While DNA breaks can be single-stranded or double-stranded, the double-stranded DNA (dsDNA) breaks are more dangerous. If such damage is not repaired, it can lead to genetic instability and serious health issues including cancers. One way dsDNA breaks can be repaired is via a process called homologous recombination (HR), which involves several DNA-binding proteins. Therefore, to have a better insight into the repair mechanism and origin of repair defects, we need a better understanding of how these proteins interact with DNA itself and DNA …