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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Novel Mechanisms Governing Autoregulation Of The Src Family Kinase Fyn And Its Crosstalk With Protein Kinase A, Marion Weir
Novel Mechanisms Governing Autoregulation Of The Src Family Kinase Fyn And Its Crosstalk With Protein Kinase A, Marion Weir
Graduate College Dissertations and Theses
ABSTRACT
Phosphorylation is a post-translational modification important for regulating protein activity and protein binding capacity. It is used in many different signaling pathways within the cell. Src Family Kinases and Protein Kinase A (PKA) are two prototyptical non-receptor tyrosine and serine/ threonine kinases, respectively, which are found in canonical signaling pathways. These two kinases are critical for signaling in essentially every cell of a multicellular organism, and are particularly important in development, cell migration and proliferation. Although both proteins have been intensely studied for many decades, an understanding of the molecular mechanisms which govern their regulation and the regulation that …