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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
The Terrestrial Biogeochemical Cycle Of Barium: A Proposed Study To Examine Barium Flux In Mojave Desert Dust, Mehar Kaur
Scripps Senior Theses
Barium is a relatively abundant element in the crustal environments, Ba quantities can range from anywhere between 200ppm to 900ppm. Most common forms of Ba-minerals found in the environment are barite (BaSO4), witherite (BaCO3) and hollandite (Ba2Mn8O16). Ba is a useful element; it is used in various industries as a component in drilling fluids, in medical research and in manufacturing of various substances such as glass, ceramics, printing paper etc. However high quantity of Ba can be potentially toxic for the human body and can impair plant growth. It is …
Solid-State Nuclear Magnetic Resonance Analysis Of Cytosine-Methylated Dna Dodecamer, Caitlin A. Edmunds
Solid-State Nuclear Magnetic Resonance Analysis Of Cytosine-Methylated Dna Dodecamer, Caitlin A. Edmunds
Scripps Senior Theses
The interaction of deoxyribonucleic acid (DNA) and cellular proteins is absolutely central to any biological understanding of DNA replication, transcription, and even gene regulation. Because an incumbent protein latches not onto the four bases but onto the backbone phosphate groups of the nucleic acid, backbone dynamics directly pertain to an understanding of basic cell processes. Studies have unambiguously proven that DNA exists in a balance of two conformations, BI and BII, defined by the difference in their backbone torsion angles. A given DNA sequence expresses a preference for either BI or BII, though both exist in most samples (and are …
Do Bha And Bht Induce Morphological Changes And Dna Double-Strand Breaks In Schizosaccharomyces Pombe?, Amy V. Tran
Do Bha And Bht Induce Morphological Changes And Dna Double-Strand Breaks In Schizosaccharomyces Pombe?, Amy V. Tran
Scripps Senior Theses
Butylated Hydroxyanisole, BHA, and Butylated Hydroxytoluene, BHT, are commonly used as preservatives for our food as well as additives in many products such as cosmetics, petroleum, and medicine. Although their use has been approved by the Food and Drug Administration (FDA), there have been controversies and debates on whether these phenol derivatives or antioxidants are safe to use. Their accumulative toxicology and side effects need to be thoroughly investigated as we continue to consume them on a daily basis. Data obtained by genomic analysis in Tang lab suggested the involvement of DNA damage checkpoint/repair pathways in the response network to …
Effect Of Hinge Region Phosphorylation On The Localization Of Thp1 In Tetrahymena Thermophila, Emily Bulley, Emily Wiley
Effect Of Hinge Region Phosphorylation On The Localization Of Thp1 In Tetrahymena Thermophila, Emily Bulley, Emily Wiley
Scripps Senior Theses
Within the cell nucleus, there are regions of highly condensed, transcriptionally silent chromatin called heterochromatin. Heterochromatin plays an important role in both chromosomal stability and gene regulation within the cell. Heterochromatin assembly is mediated by Heterochromatin Protein 1 (HP1) binding to epigenetically marked histone tails, most notably methylated H3K9. HP1 is post-translationally phosphorylated at serine and threonine residues, and this phosphorylation has been shown to increase HP1’s binding affinity for methylated H3K9 and heterochromatin formation. To study the effect of phosphorylation on heterochromatin assembly and HP1 localization within the nucleus, the unicellular protozoan Tetrahymena thermophila was used. Tetrahymena is an …