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Applications Of Transposable Elements In Fish For Transgenesis And Functional Genomics, Perry B. Hackett, Karl J. Clark, Stephen C. Ekker, Jeffrey J. Essner
Applications Of Transposable Elements In Fish For Transgenesis And Functional Genomics, Perry B. Hackett, Karl J. Clark, Stephen C. Ekker, Jeffrey J. Essner
Jeffrey J. Essner
Transgenic fish were first made more than 30 years ago. Since then a variety of methods and const ructs have been tested for introducing genetic sequences into fish for scientitlc investigations as well as commercial purposes. Here we review transposable clements and t heir applications in fish. Transposons can be used to deliver genes to chromosomes to confer new traits or as insertional agents and traps to uncover the functions and expression patterns of natural genes in chromosomes. Two DNA transposons have been characterized for transposon-based gene transfer and insertional mutagenesis. The t1rst is d1e Sleeping Beauty transposon system that …