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Full-Text Articles in Life Sciences
Drosophila Model For Fetal Alcohol Syndrome Disorders: Role For The Insulin Pathway, Rachael L. French, K D. Mcclure, U Heberlein
Drosophila Model For Fetal Alcohol Syndrome Disorders: Role For The Insulin Pathway, Rachael L. French, K D. Mcclure, U Heberlein
Rachael L. French
Prenatal exposure to ethanol in humans results in a wide range of developmental abnormalities, including growth deficiency, developmental delay, reduced brain size, permanent neurobehavioral abnormalities and fetal death. Here we describe the use of Drosophila melanogaster as a model for exploring the effects of ethanol exposure on development and behavior. We show that developmental ethanol exposure causes reduced viability, developmental delay and reduced adult body size. We find that flies reared on ethanol-containing food have smaller brains and imaginal discs, which is due to reduced cell division rather than increased apoptosis. Additionally, we show that, as in mammals, flies reared …
Drosophila Model For Fetal Alcohol Syndrome Disorders: Role For The Insulin Pathway, Rachael L. French, K D. Mcclure, U Heberlein
Drosophila Model For Fetal Alcohol Syndrome Disorders: Role For The Insulin Pathway, Rachael L. French, K D. Mcclure, U Heberlein
Faculty Publications, Biological Sciences
Prenatal exposure to ethanol in humans results in a wide range of developmental abnormalities, including growth deficiency, developmental delay, reduced brain size, permanent neurobehavioral abnormalities and fetal death. Here we describe the use of Drosophila melanogaster as a model for exploring the effects of ethanol exposure on development and behavior. We show that developmental ethanol exposure causes reduced viability, developmental delay and reduced adult body size. We find that flies reared on ethanol-containing food have smaller brains and imaginal discs, which is due to reduced cell division rather than increased apoptosis. Additionally, we show that, as in mammals, flies reared …
Contemporary And Historical Separation Of Transequatorial Migration Between Genetically Distinct Seabird Populations, M J. Rayner, M E. Hauber, T E. Steeves, H A. Lawrence, D R. Thompson, P M. Sagar, S J. Bury, R A. Phillips, T J. Landers, L Ranjard, Scott A. Shaffer
Contemporary And Historical Separation Of Transequatorial Migration Between Genetically Distinct Seabird Populations, M J. Rayner, M E. Hauber, T E. Steeves, H A. Lawrence, D R. Thompson, P M. Sagar, S J. Bury, R A. Phillips, T J. Landers, L Ranjard, Scott A. Shaffer
Scott A. Shaffer
Pelagic seabirds are highly mobile, reducing the likelihood of allopatric speciation where disruption of gene flow between populations is caused by physically insurmountable, extrinsic barriers. Spatial segregation during the non-breeding season appears to provide an intrinsic barrier to gene flow among seabird populations that otherwise occupy nearby or overlapping regions during breeding, but how this is achieved remains unclear. Here we show that the two genetically distinct populations of Cook's petrel (Pterodroma cookii) exhibit transequatorial separation of non-breeding ranges at contemporary (ca. 2–3 yrs) and historical (ca. 100 yrs) time scales. Segregation during the non-breeding season per se appears as …
Contemporary And Historical Separation Of Transequatorial Migration Between Genetically Distinct Seabird Populations, M J. Rayner, M E. Hauber, T E. Steeves, H A. Lawrence, D R. Thompson, P M. Sagar, S J. Bury, R A. Phillips, T J. Landers, L Ranjard, Scott A. Shaffer
Contemporary And Historical Separation Of Transequatorial Migration Between Genetically Distinct Seabird Populations, M J. Rayner, M E. Hauber, T E. Steeves, H A. Lawrence, D R. Thompson, P M. Sagar, S J. Bury, R A. Phillips, T J. Landers, L Ranjard, Scott A. Shaffer
Faculty Publications, Biological Sciences
Pelagic seabirds are highly mobile, reducing the likelihood of allopatric speciation where disruption of gene flow between populations is caused by physically insurmountable, extrinsic barriers. Spatial segregation during the non-breeding season appears to provide an intrinsic barrier to gene flow among seabird populations that otherwise occupy nearby or overlapping regions during breeding, but how this is achieved remains unclear. Here we show that the two genetically distinct populations of Cook's petrel (Pterodroma cookii) exhibit transequatorial separation of non-breeding ranges at contemporary (ca. 2–3 yrs) and historical (ca. 100 yrs) time scales. Segregation during the non-breeding season per se appears as …
Shearwater Foraging In The Southern Ocean: The Roles Of Prey Availability And Winds, B Raymond, Scott A. Shaffer, S Sokolov, E Woehler, D P. Costa, L Einoder, M Hindell, G Hosie, M Pinkerton, P M. Sagar, D Scott, A Smith, D R. Thompson, C Vertigan, H Weimerskirch
Shearwater Foraging In The Southern Ocean: The Roles Of Prey Availability And Winds, B Raymond, Scott A. Shaffer, S Sokolov, E Woehler, D P. Costa, L Einoder, M Hindell, G Hosie, M Pinkerton, P M. Sagar, D Scott, A Smith, D R. Thompson, C Vertigan, H Weimerskirch
Scott A. Shaffer
Background Sooty (Puffinus griseus) and short-tailed (P. tenuirostris) shearwaters are abundant seabirds that range widely across global oceans. Understanding the foraging ecology of these species in the Southern Ocean is important for monitoring and ecosystem conservation and management. Methodology/Principal Findings Tracking data from sooty and short-tailed shearwaters from three regions of New Zealand and Australia were combined with at-sea observations of shearwaters in the Southern Ocean, physical oceanography, near-surface copepod distributions, pelagic trawl data, and synoptic near-surface winds. Shearwaters from all three regions foraged in the Polar Front zone, and showed particular overlap in the region around 140°E. Short-tailed shearwaters …
Niche Partitioning Among And Within Sympatric Tropical Seabirds Revealed By Stable Isotope Analysis, H S. Young, D J. Mccauley, R Dirzo, R D. Dunbar, Scott A. Shaffer
Niche Partitioning Among And Within Sympatric Tropical Seabirds Revealed By Stable Isotope Analysis, H S. Young, D J. Mccauley, R Dirzo, R D. Dunbar, Scott A. Shaffer
Scott A. Shaffer
The low productivity and unpredictable nature of resources in tropical waters would appear to make resource partitioning among predators difficult. Yet, stable isotope data from the present study suggest that substantial resource partitioning occurs among tropical seabird communities, both between and within species. In the present study, we compared δ13C and δ15N levels among 8 sympatric tropical seabird species. For a subset of these species, we also examined isotopic levels across years, breeding periods, and sexes. When breeding and non-breeding periods were both considered, we found that all species occupied distinct isotopic niches across at least one time period. Resource …
Shearwater Foraging In The Southern Ocean: The Roles Of Prey Availability And Winds, B Raymond, Scott A. Shaffer, S Sokolov, E Woehler, D P. Costa, L Einoder, M Hindell, G Hosie, M Pinkerton, P M. Sagar, D Scott, A Smith, D R. Thompson, C Vertigan, H Weimerskirch
Shearwater Foraging In The Southern Ocean: The Roles Of Prey Availability And Winds, B Raymond, Scott A. Shaffer, S Sokolov, E Woehler, D P. Costa, L Einoder, M Hindell, G Hosie, M Pinkerton, P M. Sagar, D Scott, A Smith, D R. Thompson, C Vertigan, H Weimerskirch
Faculty Publications, Biological Sciences
Background Sooty (Puffinus griseus) and short-tailed (P. tenuirostris) shearwaters are abundant seabirds that range widely across global oceans. Understanding the foraging ecology of these species in the Southern Ocean is important for monitoring and ecosystem conservation and management. Methodology/Principal Findings Tracking data from sooty and short-tailed shearwaters from three regions of New Zealand and Australia were combined with at-sea observations of shearwaters in the Southern Ocean, physical oceanography, near-surface copepod distributions, pelagic trawl data, and synoptic near-surface winds. Shearwaters from all three regions foraged in the Polar Front zone, and showed particular overlap in the region around 140°E. Short-tailed shearwaters …
Niche Partitioning Among And Within Sympatric Tropical Seabirds Revealed By Stable Isotope Analysis, H S. Young, D J. Mccauley, R Dirzo, R D. Dunbar, Scott A. Shaffer
Niche Partitioning Among And Within Sympatric Tropical Seabirds Revealed By Stable Isotope Analysis, H S. Young, D J. Mccauley, R Dirzo, R D. Dunbar, Scott A. Shaffer
Faculty Publications, Biological Sciences
The low productivity and unpredictable nature of resources in tropical waters would appear to make resource partitioning among predators difficult. Yet, stable isotope data from the present study suggest that substantial resource partitioning occurs among tropical seabird communities, both between and within species. In the present study, we compared δ13C and δ15N levels among 8 sympatric tropical seabird species. For a subset of these species, we also examined isotopic levels across years, breeding periods, and sexes. When breeding and non-breeding periods were both considered, we found that all species occupied distinct isotopic niches across at least one time period. Resource …
Bringing Home The Trash: Do Differences In Foraging Lead To Increased Plastic Ingestion In Laysan Albatrosses?, L C. Young, C Vanderlip, D C. Duffy, V Afanasyev, Scott A. Shaffer
Bringing Home The Trash: Do Differences In Foraging Lead To Increased Plastic Ingestion In Laysan Albatrosses?, L C. Young, C Vanderlip, D C. Duffy, V Afanasyev, Scott A. Shaffer
Scott A. Shaffer
When searching for prey, animals should maximize energetic gain, while minimizing energy expenditure by altering their movements relative to prey availability. However, with increasing amounts of marine debris, what once may have been ‘optimal’ foraging strategies for top marine predators, are leading to sub-optimal diets comprised in large part of plastic. Indeed, the highly vagile Laysan albatross (Phoebastria immutabilis) which forages throughout the North Pacific, are well known for their tendency to ingest plastic. Here we examine whether Laysan albatrosses nesting on Kure Atoll and Oahu Island, 2,150 km apart, experience different levels of plastic ingestion. Twenty two geolocators were …
Bringing Home The Trash: Do Differences In Foraging Lead To Increased Plastic Ingestion In Laysan Albatrosses?, L C. Young, C Vanderlip, D C. Duffy, V Afanasyev, Scott A. Shaffer
Bringing Home The Trash: Do Differences In Foraging Lead To Increased Plastic Ingestion In Laysan Albatrosses?, L C. Young, C Vanderlip, D C. Duffy, V Afanasyev, Scott A. Shaffer
Faculty Publications, Biological Sciences
When searching for prey, animals should maximize energetic gain, while minimizing energy expenditure by altering their movements relative to prey availability. However, with increasing amounts of marine debris, what once may have been ‘optimal’ foraging strategies for top marine predators, are leading to sub-optimal diets comprised in large part of plastic. Indeed, the highly vagile Laysan albatross (Phoebastria immutabilis) which forages throughout the North Pacific, are well known for their tendency to ingest plastic. Here we examine whether Laysan albatrosses nesting on Kure Atoll and Oahu Island, 2,150 km apart, experience different levels of plastic ingestion. Twenty two geolocators were …
Assessing Osteoporosis Learning Needs And Preferences Of Exercise Physiologists, P D. Sollis, C J. Cisar
Assessing Osteoporosis Learning Needs And Preferences Of Exercise Physiologists, P D. Sollis, C J. Cisar
Craig J. Cisar
Research has revealed substantial knowledge deficits regarding osteoporosis among various healthcare professionals, such as physicians, nurses, and physical therapists. However, no previous studies have addressed the levels of knowledge regarding osteoporosis among exercise physiologists working in a cardiopulmonary rehabilitation setting. It is essential that exercise physiologists have a thorough understanding of osteoporosis so they can ensure client safety and provide accurate information to the client and support group. The purpose of this project was to evaluate the levels of knowledge about osteoporosis among exercise physiologists working with clients who are at high risk for fragility fractures. Ninety-six exercise physiologists (female …
Perspectives In Ornithology: Application Of Tracking And Data-Logging Technology In Research And Conservation Of Seabirds, A E. Burger, Scott A. Shaffer
Perspectives In Ornithology: Application Of Tracking And Data-Logging Technology In Research And Conservation Of Seabirds, A E. Burger, Scott A. Shaffer
Scott A. Shaffer
No abstract provided.
Wind, Waves, And Wing Loading: Their Relative Importance To The At-Sea Distribution And Movements Of North And Central Pacific Albatrosses, R M. Suryan, D J. Anderson, Scott A. Shaffer, D D. Roby, Y Tremblay, D P. Costa, F Sato, K Ozaki, G Balogh
Wind, Waves, And Wing Loading: Their Relative Importance To The At-Sea Distribution And Movements Of North And Central Pacific Albatrosses, R M. Suryan, D J. Anderson, Scott A. Shaffer, D D. Roby, Y Tremblay, D P. Costa, F Sato, K Ozaki, G Balogh
Scott A. Shaffer
Among the varied adaptations for avian flight, the morphological traits allowing large-bodied albatrosses to capitalize on wind and wave energy for efficient long-distance flight are unparalleled. Consequently, the biogeographic distribution of most albatrosses is limited to the windiest oceanic regions on earth; however, exceptions exist. Species breeding in the North and Central Pacific Ocean (Phoebastria spp.) inhabit regions of lower wind speed and wave height than southern hemisphere genera, and have large intrageneric variation in body size and aerodynamic performance. Here, we test the hypothesis that regional wind and wave regimes explain observed differences in Phoebastria albatross morphology and we …
Assessing Osteoporosis Learning Needs And Preferences Of Exercise Physiologists, P D. Sollis, C J. Cisar
Assessing Osteoporosis Learning Needs And Preferences Of Exercise Physiologists, P D. Sollis, C J. Cisar
Faculty Publications
Research has revealed substantial knowledge deficits regarding osteoporosis among various healthcare professionals, such as physicians, nurses, and physical therapists. However, no previous studies have addressed the levels of knowledge regarding osteoporosis among exercise physiologists working in a cardiopulmonary rehabilitation setting. It is essential that exercise physiologists have a thorough understanding of osteoporosis so they can ensure client safety and provide accurate information to the client and support group. The purpose of this project was to evaluate the levels of knowledge about osteoporosis among exercise physiologists working with clients who are at high risk for fragility fractures. Ninety-six exercise physiologists (female …
Perspectives In Ornithology: Application Of Tracking And Data-Logging Technology In Research And Conservation Of Seabirds, A E. Burger, Scott A. Shaffer
Perspectives In Ornithology: Application Of Tracking And Data-Logging Technology In Research And Conservation Of Seabirds, A E. Burger, Scott A. Shaffer
Faculty Publications, Biological Sciences
No abstract provided.
Wind, Waves, And Wing Loading: Their Relative Importance To The At-Sea Distribution And Movements Of North And Central Pacific Albatrosses, R M. Suryan, D J. Anderson, Scott A. Shaffer, D D. Roby, Y Tremblay, D P. Costa, F Sato, K Ozaki, G Balogh
Wind, Waves, And Wing Loading: Their Relative Importance To The At-Sea Distribution And Movements Of North And Central Pacific Albatrosses, R M. Suryan, D J. Anderson, Scott A. Shaffer, D D. Roby, Y Tremblay, D P. Costa, F Sato, K Ozaki, G Balogh
Faculty Publications, Biological Sciences
Among the varied adaptations for avian flight, the morphological traits allowing large-bodied albatrosses to capitalize on wind and wave energy for efficient long-distance flight are unparalleled. Consequently, the biogeographic distribution of most albatrosses is limited to the windiest oceanic regions on earth; however, exceptions exist. Species breeding in the North and Central Pacific Ocean (Phoebastria spp.) inhabit regions of lower wind speed and wave height than southern hemisphere genera, and have large intrageneric variation in body size and aerodynamic performance. Here, we test the hypothesis that regional wind and wave regimes explain observed differences in Phoebastria albatross morphology and we …
Corticosterone And Foraging Behaviour In A Pelagic Seabird, F Angelier, Scott A. Shaffer, H Weimerskirch, C Trouvé, O Chastel
Corticosterone And Foraging Behaviour In A Pelagic Seabird, F Angelier, Scott A. Shaffer, H Weimerskirch, C Trouvé, O Chastel
Scott A. Shaffer
Because endocrine mechanisms are thought to mediate behavioral responses to changes in the environment, examining these mechanisms is essential for understanding how long-lived seabirds adjust their foraging decisions to contrasting environmental conditions in order to maximize their fitness. In this context, the hormone corticosterone (CORT) deserves specific attention because of its major connections with locomotor activities. We examined for the first time the relationships between individual CORT levels and measurements of foraging success and behavior using satellite tracking and blood sampling from wandering albatrosses (Diomedea exulans) before (pretrip CORT levels) and after (posttrip CORT levels) foraging trips during the incubation …
Corticosterone And Foraging Behaviour In A Pelagic Seabird, F Angelier, Scott A. Shaffer, H Weimerskirch, C Trouvé, O Chastel
Corticosterone And Foraging Behaviour In A Pelagic Seabird, F Angelier, Scott A. Shaffer, H Weimerskirch, C Trouvé, O Chastel
Faculty Publications, Biological Sciences
Because endocrine mechanisms are thought to mediate behavioral responses to changes in the environment, examining these mechanisms is essential for understanding how long-lived seabirds adjust their foraging decisions to contrasting environmental conditions in order to maximize their fitness. In this context, the hormone corticosterone (CORT) deserves specific attention because of its major connections with locomotor activities. We examined for the first time the relationships between individual CORT levels and measurements of foraging success and behavior using satellite tracking and blood sampling from wandering albatrosses (Diomedea exulans) before (pretrip CORT levels) and after (posttrip CORT levels) foraging trips during the incubation …
Validation Of Water Flux And Body Composition In Glaucous Gulls (Larus Hyperboreus), Scott A. Shaffer, Gabrielsen, G.W., Verreault, J, Costa, D.P
Validation Of Water Flux And Body Composition In Glaucous Gulls (Larus Hyperboreus), Scott A. Shaffer, Gabrielsen, G.W., Verreault, J, Costa, D.P
Scott A. Shaffer
Water influx rates (WIR) measured with tritiated water dilution were compared with direct measures of water and energy intake in glaucous gulls (Larus hyperboreus). Total body water (TBW) measured isotopically was also compared with TBW determined by body composition analysis (BCA) of the same birds. Seventeen wild gulls were captured and studied in outdoor enclosures at Ny-Ålesund, Svalbard, in July 2002. Gulls were hand-fed known quantities of Arctic cod (Boreogadus saida) or given water on the basis of one of four experimental treatments: (A) fasting, (B) fish only, (C) water only, or (D) fish and water. Water and energy content …
A Database For The Study Of Marine Mammal Behavior: Gap Analysis, Data Standardization, And Future Directions, Scott A. Shaffer, D P. Costa
A Database For The Study Of Marine Mammal Behavior: Gap Analysis, Data Standardization, And Future Directions, Scott A. Shaffer, D P. Costa
Scott A. Shaffer
A relational database that contained published information on the diving behavior and/or movement patterns of marine mammals was compiled to facilitate a modeling effort of the Effects of Sound on the Marine Environment (ESME) program. A total of 448 references from reports, books, and peer-reviewed journal articles were obtained. The metadata describing each animal studied, location of the study, and equipment used were entered into the database as well as empirical data describing the diving behavior and movement patterns of each animal. In total, the database contained 1815 entries from 51 different marine mammal species or subspecies. The majority of …
Farnesylated Lamins, Progeroid Syndromes And Farnesyl Transferase Inhibitors, Michael Sinensky, A. E. Rusinol
Farnesylated Lamins, Progeroid Syndromes And Farnesyl Transferase Inhibitors, Michael Sinensky, A. E. Rusinol
Michael Sinensky
Three mammalian nuclear lamin proteins, lamin B1, lamin B2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis, which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive dermopathy (RD). These two diseases arise respectively from defects in the prelamin A substrate and the enzyme (ZmpSte24) that processes it. Recent work has shed light on the roles of the lamin proteins and the enzymes involved in their farnesylation-dependent maturation. Other experimental work, including mouse model studies, have examined the possibility …
Dna Damage Responses In Progeroid Syndromes Arise From Defective Maturation Of Prelamin A, Michael Sinensky, Y. Liu, A. Rusinol, Y. Wang, Y. Zou
Dna Damage Responses In Progeroid Syndromes Arise From Defective Maturation Of Prelamin A, Michael Sinensky, Y. Liu, A. Rusinol, Y. Wang, Y. Zou
Michael Sinensky
The genetic diseases Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) arise from accumulation of farnesylated prelamin A because of defects in the lamin A maturation pathway. Both of these diseases exhibit symptoms that can be viewed as accelerated aging. The mechanism by which accumulation of farnesylated prelamin A leads to these accelerated aging phenotypes is not understood. Here we present evidence that in HGPS and RD fibroblasts, DNA damage checkpoints are persistently activated because of the compromise in genomic integrity. Inactivation of checkpoint kinases Ataxia-telangiectasia-mutated (ATM) and ATR (ATM- and Rad3-related) in these patient cells can partially overcome their …
Interpolation Of Tracking Data In A Fluid Environment, Y Tremblay, Scott A. Shaffer, S L. Fowler, C E. Kuhn, B I. Mcdonald, M J. Weise, C -A Bost, H Weimerskirch, D E. Crocker, M E. Goebel, D P. Costa
Interpolation Of Tracking Data In A Fluid Environment, Y Tremblay, Scott A. Shaffer, S L. Fowler, C E. Kuhn, B I. Mcdonald, M J. Weise, C -A Bost, H Weimerskirch, D E. Crocker, M E. Goebel, D P. Costa
Scott A. Shaffer
Interpolation of geolocation or Argos tracking data is a necessity for habitat use analyses of marine vertebrates. In a fluid marine environment, characterized by curvilinear structures, linearly interpolated track data are not realistic. Based on these two facts, we interpolated tracking data from albatrosses, penguins, boobies, sea lions, fur seals and elephant seals using six mathematical algorithms. Given their popularity in mathematical computing, we chose Bézier, hermite and cubic splines, in addition to a commonly used linear algorithm to interpolate data. Performance of interpolation methods was compared with different temporal resolutions representative of the less-precise geolocation and the more-precise Argos …
Farnesylated Lamins, Progeroid Syndromes And Farnesyl Transferase Inhibitors, Michael Sinensky, A. E. Rusinol
Farnesylated Lamins, Progeroid Syndromes And Farnesyl Transferase Inhibitors, Michael Sinensky, A. E. Rusinol
Faculty Publications, Biological Sciences
Three mammalian nuclear lamin proteins, lamin B1, lamin B2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis, which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive dermopathy (RD). These two diseases arise respectively from defects in the prelamin A substrate and the enzyme (ZmpSte24) that processes it. Recent work has shed light on the roles of the lamin proteins and the enzymes involved in their farnesylation-dependent maturation. Other experimental work, including mouse model studies, have examined the possibility …
Dna Damage Responses In Progeroid Syndromes Arise From Defective Maturation Of Prelamin A, Michael Sinensky, Y. Liu, A. Rusinol, Y. Wang, Y. Zou
Dna Damage Responses In Progeroid Syndromes Arise From Defective Maturation Of Prelamin A, Michael Sinensky, Y. Liu, A. Rusinol, Y. Wang, Y. Zou
Faculty Publications, Biological Sciences
The genetic diseases Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) arise from accumulation of farnesylated prelamin A because of defects in the lamin A maturation pathway. Both of these diseases exhibit symptoms that can be viewed as accelerated aging. The mechanism by which accumulation of farnesylated prelamin A leads to these accelerated aging phenotypes is not understood. Here we present evidence that in HGPS and RD fibroblasts, DNA damage checkpoints are persistently activated because of the compromise in genomic integrity. Inactivation of checkpoint kinases Ataxia-telangiectasia-mutated (ATM) and ATR (ATM- and Rad3-related) in these patient cells can partially overcome their …
A Database For The Study Of Marine Mammal Behavior: Gap Analysis, Data Standardization, And Future Directions, Scott A. Shaffer, D P. Costa
A Database For The Study Of Marine Mammal Behavior: Gap Analysis, Data Standardization, And Future Directions, Scott A. Shaffer, D P. Costa
Faculty Publications, Biological Sciences
A relational database that contained published information on the diving behavior and/or movement patterns of marine mammals was compiled to facilitate a modeling effort of the Effects of Sound on the Marine Environment (ESME) program. A total of 448 references from reports, books, and peer-reviewed journal articles were obtained. The metadata describing each animal studied, location of the study, and equipment used were entered into the database as well as empirical data describing the diving behavior and movement patterns of each animal. In total, the database contained 1815 entries from 51 different marine mammal species or subspecies. The majority of …
Validation Of Water Flux And Body Composition In Glaucous Gulls (Larus Hyperboreus), Scott A. Shaffer, Gabrielsen, G.W., Verreault, J, Costa, D.P
Validation Of Water Flux And Body Composition In Glaucous Gulls (Larus Hyperboreus), Scott A. Shaffer, Gabrielsen, G.W., Verreault, J, Costa, D.P
Faculty Publications, Biological Sciences
Water influx rates (WIR) measured with tritiated water dilution were compared with direct measures of water and energy intake in glaucous gulls (Larus hyperboreus). Total body water (TBW) measured isotopically was also compared with TBW determined by body composition analysis (BCA) of the same birds. Seventeen wild gulls were captured and studied in outdoor enclosures at Ny-Ålesund, Svalbard, in July 2002. Gulls were hand-fed known quantities of Arctic cod (Boreogadus saida) or given water on the basis of one of four experimental treatments: (A) fasting, (B) fish only, (C) water only, or (D) fish and water. Water and energy content …
Interpolation Of Tracking Data In A Fluid Environment, Y Tremblay, Scott A. Shaffer, S L. Fowler, C E. Kuhn, B I. Mcdonald, M J. Weise, C -A Bost, H Weimerskirch, D E. Crocker, M E. Goebel, D P. Costa
Interpolation Of Tracking Data In A Fluid Environment, Y Tremblay, Scott A. Shaffer, S L. Fowler, C E. Kuhn, B I. Mcdonald, M J. Weise, C -A Bost, H Weimerskirch, D E. Crocker, M E. Goebel, D P. Costa
Faculty Publications, Biological Sciences
Interpolation of geolocation or Argos tracking data is a necessity for habitat use analyses of marine vertebrates. In a fluid marine environment, characterized by curvilinear structures, linearly interpolated track data are not realistic. Based on these two facts, we interpolated tracking data from albatrosses, penguins, boobies, sea lions, fur seals and elephant seals using six mathematical algorithms. Given their popularity in mathematical computing, we chose Bézier, hermite and cubic splines, in addition to a commonly used linear algorithm to interpolate data. Performance of interpolation methods was compared with different temporal resolutions representative of the less-precise geolocation and the more-precise Argos …
Reduced Macrophage Apoptosis Is Associated With Accelerated Atherosclerosis In Low-Denstiy Lipoprotein Receptor-Null Mice, Michael Sinensky, J. Liu, D. P. Thweke, Y. R. Su, M. F. Linton, S. Fazio
Reduced Macrophage Apoptosis Is Associated With Accelerated Atherosclerosis In Low-Denstiy Lipoprotein Receptor-Null Mice, Michael Sinensky, J. Liu, D. P. Thweke, Y. R. Su, M. F. Linton, S. Fazio
Michael Sinensky
Objective— The majority of apoptotic cells in atherosclerotic lesions are macrophages. However, the pathogenic role of macrophage apoptosis in the development of atherosclerosis remains unclear. Elevated expression of Bax, one of the pivotal proapoptotic proteins of the Bcl-2 family, has been found in human atherosclerotic plaques. Activation of Bax also occurs in free cholesterol-loaded and oxysterol-treated mouse macrophages. In this study, we examined the effect of Bax deficiency in bone marrow-derived leukocytes on the development of atherosclerosis in low-density lipoprotein receptor-null (LDLR−/−) mice. Methods and Results— Fourteen 8-week-old male LDLR−/− mice were lethally irradiated and reconstituted with either wild-type (WT) …
Reduced Macrophage Apoptosis Is Associated With Accelerated Atherosclerosis In Low-Denstiy Lipoprotein Receptor-Null Mice, Michael Sinensky, J. Liu, D. P. Thweke, Y. R. Su, M. F. Linton, S. Fazio
Reduced Macrophage Apoptosis Is Associated With Accelerated Atherosclerosis In Low-Denstiy Lipoprotein Receptor-Null Mice, Michael Sinensky, J. Liu, D. P. Thweke, Y. R. Su, M. F. Linton, S. Fazio
Faculty Publications, Biological Sciences
Objective— The majority of apoptotic cells in atherosclerotic lesions are macrophages. However, the pathogenic role of macrophage apoptosis in the development of atherosclerosis remains unclear. Elevated expression of Bax, one of the pivotal proapoptotic proteins of the Bcl-2 family, has been found in human atherosclerotic plaques. Activation of Bax also occurs in free cholesterol-loaded and oxysterol-treated mouse macrophages. In this study, we examined the effect of Bax deficiency in bone marrow-derived leukocytes on the development of atherosclerosis in low-density lipoprotein receptor-null (LDLR−/−) mice. Methods and Results— Fourteen 8-week-old male LDLR−/− mice were lethally irradiated and reconstituted with either wild-type (WT) …