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Full-Text Articles in Life Sciences
The Product Of The Saccharomyces Cerevisiae Rss1 Gene, Identified As A High-Copy Suppressor Of The Rat7-1 Temperature-Sensitive Allele Of The Rat7/Nup159 Nucleoporin, Is Required For Efficient Mrna Export, Veronica Del Priore, Christine A. Snay, Andre Bahr, Charles N. Cole
The Product Of The Saccharomyces Cerevisiae Rss1 Gene, Identified As A High-Copy Suppressor Of The Rat7-1 Temperature-Sensitive Allele Of The Rat7/Nup159 Nucleoporin, Is Required For Efficient Mrna Export, Veronica Del Priore, Christine A. Snay, Andre Bahr, Charles N. Cole
Dartmouth Scholarship
RAT7/NUP159 was identified previously in a screen for genes whose products are important for nucleocytoplasmic export of poly(A)+ RNA and encodes an essential nucleoporin. We report here the identification of RSS1 (Rat Seven Suppressor) as a high-copy extragenic suppressor of the rat7-1 temperature-sensitive allele. Rss1p encodes a novel essential protein of 538 amino acids, which contains an extended predicted coiled-coil domain and is located both at nuclear pore complexes (NPCs) and in the cytoplasm. RSS1 is the first reported high-copy extragenic suppressor of a mutant nucleoporin. Overexpression of Rss1p partially suppresses the defects in nucleocytoplasmic export of poly(A)+ RNA, rRNA …
Multiple-Trait Gibbs Sampler For Animal Models: Flexible Programs For Bayesian And Likelihood-Based (Co)Variance Component Inference, C. P. Van Tassell, L. Dale Van Vleck
Multiple-Trait Gibbs Sampler For Animal Models: Flexible Programs For Bayesian And Likelihood-Based (Co)Variance Component Inference, C. P. Van Tassell, L. Dale Van Vleck
Department of Animal Science: Faculty Publications
A set of FORTRAN programs to implement a multiple-trait Gibbs sampling algorithm for (co)variance component inference in animal models (MTGSAM) was developed. The MTGSAM programs are available to the public. The programs support models with correlated genetic effects and arbitrary numbers of covariates, fixed effects, and independent random effects for each trait. Any combination of missing traits is allowed. The programs were used to estimate variance components for 50 replicates of simulated data. Each replicate consisted of 50 animals of each sex in each of four generations, for 400 animals in each replicate for two traits. For MTGSAM, informative prior …
A Novel Iron-Regulated Metal Transporter From Plants Identified By Functional Expression In Yeast., David Eide, Margaret Broderius, Jeanette Fett, Mary Lou Guerinot
A Novel Iron-Regulated Metal Transporter From Plants Identified By Functional Expression In Yeast., David Eide, Margaret Broderius, Jeanette Fett, Mary Lou Guerinot
Dartmouth Scholarship
Iron is an essential nutrient for virtually all organisms. The IRT1 (iron-regulated transporter) gene of the plant Arabidopsis thaliana, encoding a probable Fe(II) transporter, was cloned by functional expression in a yeast strain defective for iron uptake. Yeast expressing IRT1 possess a novel Fe(II) uptake activity that is strongly inhibited by Cd. IRT1 is predicted to be an integral membrane protein with a metal-binding domain. Data base comparisons and Southern blot analysis indicated that IRT1 is a member of a gene family in Arabidopsis. Related sequences were also found in the genomes of rice, yeast, nematodes, and humans. In Arabidopsis, …
Postpollination Mechanisms Influencing Mating Patterns And Fecundity: An Example From Eichhornia Paniculata, Mitchell B. Cruzan
Postpollination Mechanisms Influencing Mating Patterns And Fecundity: An Example From Eichhornia Paniculata, Mitchell B. Cruzan
Biology Faculty Publications and Presentations
Plant mating systems are influenced by the amount and genetic composition of pollen grains deposited on stigmas and by the ability of recipients to discriminate among pollen from different sources. We describe an experimental procedure that uses limiting and excess pollinations with mixtures of genetically marked pollen to partition the siring success of donors into three components: prefertilization gamete attrition (failure of male gametophytes before fertilization), pollen competitive ability (differences in pollen tube growth rate), and postfertilization gamete attrition (embryo abortion). Regression models for the relationships of pollen load size with each pollen's siring success and total recipient fecundity indicate …
Variances Of Additive And Dominance Genetic Effects For Ovulation And Twinning Rates In A Population Selected For Twinning, L. Dale Van Vleck, K. E. Gregory
Variances Of Additive And Dominance Genetic Effects For Ovulation And Twinning Rates In A Population Selected For Twinning, L. Dale Van Vleck, K. E. Gregory
Department of Animal Science: Faculty Publications
Estimates of variances due to additive and dominance genetic effects and permanent and temporary environmental effects were obtained for ovulation and twinning rates from a composite population selected for twinning rate. Measures of ovulation rate after 11 mo of age on 2,317 heifers with a total of 19,209 measures were used. Twinning measures were on 1,522 first-parity cows, 1,311 later-parity cows with a total of 3,571 measures, and 1,704 all-parity cows with 5,100 measures. Models included fixed effects of year-season-age at calving for twinning, and year-season of birth, age in months, and calendar month of measurement for ovulation rate. Four …