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Climate change

2014

Departmental Papers (Biology)

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Full-Text Articles in Life Sciences

Evolution Of Tnf-Induced Apoptosis Reveals 550 My Of Functional Conservation, Steven D. Quistad, Aleksandr Stotland, Katie Barott, Cameron A. Smurthwaite, Brett J. Hilton, Juris A. Grasis, Roland Wolkowicz, Forest Rohwer Jan 2014

Evolution Of Tnf-Induced Apoptosis Reveals 550 My Of Functional Conservation, Steven D. Quistad, Aleksandr Stotland, Katie Barott, Cameron A. Smurthwaite, Brett J. Hilton, Juris A. Grasis, Roland Wolkowicz, Forest Rohwer

Departmental Papers (Biology)

The Precambrian explosion led to the rapid appearance of most major animal phyla alive today. It has been argued that the complexity of life has steadily increased since that event. Here we challenge this hypothesis through the characterization of apoptosis in reef-building corals, representatives of some of the earliest animals. Bioinformatic analysis reveals that all of the major components of the death receptor pathway are present in coral with high-predicted structural conservation with Homo sapiens. The TNF receptor-ligand superfamilies (TNFRSF/TNFSF) are central mediators of the death receptor pathway, and the predicted proteome of Acropora digitifera contains more putative coral ...