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2021

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Articles 541 - 570 of 13566

Full-Text Articles in Life Sciences

Characterization Of The Atpase Activity Of Casding, Christian Cahoon Dec 2021

Characterization Of The Atpase Activity Of Casding, Christian Cahoon

Fall Student Research Symposium 2021

The battle between bacteria and phage has been ongoing for eons. This battle has generated the evolutionary pressure necessary for the development of microbial immune systems. Characterization of these systems has led to the discovery of molecular tools such CRISPR-Cas systems. This system uses a genetic memory of past viral infections coupled with associated proteins to form ribonucleoprotein complexes which seek out and destroy foreign genetic elements. These systems have been repurposed by scientists to create powerful gene editing tools such as Cas9. With such powerful molecular tools being discovered, we have pursued the characterization of a relatively unknown system, …

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Synthetic Hagfish Slime Mimetics: Mechanical Characterization, Hayden Johns, Spencer Walker Dec 2021

Synthetic Hagfish Slime Mimetics: Mechanical Characterization, Hayden Johns, Spencer Walker

Fall Student Research Symposium 2021

Hagfish are ancient animals that eject a slime when attacked by predators. The slime that the hagfish emit is almost entirely composed of water but protein strands within the slime cause the slime to have incredible strength. However, these protein strands will be formed synthetically for the purposes of our experiment. To defend against foes, the Navy launches plastic ropes into the propellers of enemy warships in order to decrease the thrust of the motors. In a push to find a more biodegradable solution, the utilization of hagfish slime has shown great promise in stopping propellers.While we know that the …

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The Effects Of Various Carbon Sources And The Presence Of Vitamin B-12 On The Production Of 1,3-Propanediol By L. Reuteri., Kayden Stevenson Dec 2021

The Effects Of Various Carbon Sources And The Presence Of Vitamin B-12 On The Production Of 1,3-Propanediol By L. Reuteri., Kayden Stevenson

Fall Student Research Symposium 2021

Dairy product preservation has evolved over thousands of years and has been a major benefit to humanity by creating stable, nutrient-dense food sources. Today the lactic acid bacteria Lactobacillus reuteri is important in preserving fermented dairy products through the production of the compound reuterin. Reuterin (1,3-propanediol) demonstrates antibiotic properties that prevent the fermentation of dairy products by undesirable bacteria. The purpose of this study is to determine if L. reuteri can produce 1,3-propanediol from a variety of carbon sources. Bacterial strains were incubated in the presence of a carbon source with vitamin B-12 or without B-12 for seven days with …

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Estimating Cattle Density Using Wildlife Cameras, Emily Bonebrake Dec 2021

Estimating Cattle Density Using Wildlife Cameras, Emily Bonebrake

Fall Student Research Symposium 2021

Quantifying the abundance and distribution of animal populations is critical for effective wildlife research and management. Due to their cost-effectiveness, wildlife cameras have become an increasingly popular tool for estimating population densities. Previously, this technique relied on ‘capture-recapture’ models that utilized re-sightings of individually marked animals, but in recent years methods have been developed to estimate the population densities of unmarked animals. One such method is the random encounter and staying time (REST) technique, which does this by assuming that the cumulative time animals stay within the view of the camera scales linearly with the number of individuals. This allows …

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Determining The Nucleic Acid Binding Affinities Of Crispr-Associated Ding (Casding), Matt Armbrust Dec 2021

Determining The Nucleic Acid Binding Affinities Of Crispr-Associated Ding (Casding), Matt Armbrust

Fall Student Research Symposium 2021

CRISPR-Cas systems are adaptive prokaryotic immune systems that enable host cells to defend against attack from foreign nucleic acids such as phage infections or plasmids. CRISPR-Cas systems are diverse and encompass 2 classes, 6 types, and 33 subtypes. The Type IV-A CRISPR-Cas system from Pseudomonas aeruginosa strain 83 is composed of five different genes (csf1, csf2, csf3, cas6, and dinG). Type IV-A systems are poorly understood, and currently there is little research detailing their biological and biochemical mechanism of immunity. CasDinG, an ancillary protein within the Type IV-A system, is required for an immune response in vivo. However, the role …

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Climate Change Impacts On Atmospheric Ammonia And Implications For Human Health, Casey Olson, Connor Snow, Bridger Jorgensen Dec 2021

Climate Change Impacts On Atmospheric Ammonia And Implications For Human Health, Casey Olson, Connor Snow, Bridger Jorgensen

Fall Student Research Symposium 2021

According to national data Cache Valley has the highest concentrations of atmospheric ammonia in the nation. This study aims to answer the questions of whether climate variables and events such as precipitation, averaged winds, geopotential height, and teleconnections can be used to predict the behavior of pollutants and how human biology is potentially affected. Data from the Utah Climate Center shows that the 3rd yearly quartile has the highest levels of airborne ammonia due to the high levels of fertilizer use and livestock emissions in the farming industry in Cache Valley. After data analysis, there seems to be a connection …

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Halotolerant Rhizosphere Bacteria: Isolation Of Rhizosphere Bacteria From Native Utah Plant Ceanothus Velutinus, Alyssa Nielsen Dec 2021

Halotolerant Rhizosphere Bacteria: Isolation Of Rhizosphere Bacteria From Native Utah Plant Ceanothus Velutinus, Alyssa Nielsen

Fall Student Research Symposium 2021

Increasing incidences of drought forced farmers to use the secondary, degraded water for irrigation. These water sources are rich in salt concentrations. This project has started with the hopes of finding bacteria from the rhizosphere of a native to Utah plant, Ceanothus velutinus, that helps the plant survive the saltier conditions of Utah. The rhizosphere, a layer of soil attached to the roots of a plant, contains microorganisms that may contribute to the plants' abiotic and biotic stress resistance. These microorganisms are known as Plant Growth Promoting Rhizobacteria (PGPR). The roots and rhizosphere samples were collected from Tony Grove in …

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Effect Of Basal Diet And Black Raspberry Supplementation On Gene Biomarkers Of "Leaky Gut" In Mouse Model Of Colitis-Associated Colorectal Cancer, Eliza Stewart Dec 2021

Effect Of Basal Diet And Black Raspberry Supplementation On Gene Biomarkers Of "Leaky Gut" In Mouse Model Of Colitis-Associated Colorectal Cancer, Eliza Stewart

Fall Student Research Symposium 2021

Colorectal cancer is currently the third leading cause of cancer death in the world. The risk of developing colorectal cancer increases significantly in individuals who suffer from colitis, which is inflammation of the colon lining, seen in Irritable Bowel Disease. The term “leaky gut” is often used to describe increased intestinal permeability and is closely related to colitis. Leaky gut is associated with dysbiosis of the gut microbiota, which can occur through diet. This dysbiosis leads to pro-longed inflammation and affects genes that encode for proteins involved in the tight junctions between cells. Compromised intestinal integrity allows for translocation of …

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Understanding How Changes In Precipitation Intensity Will Affect Vegetation In The Western U.S., Cristina Chirvasa Dec 2021

Understanding How Changes In Precipitation Intensity Will Affect Vegetation In The Western U.S., Cristina Chirvasa

Fall Student Research Symposium 2021

Precipitation events are becoming more intense as the atmosphere warms, but it remains unclear how precipitation intensification will affect plant growth in arid and semiarid ecosystems. There is conflicting evidence suggesting that larger precipitation events may either increase or decrease plant growth. Here, we report the growth responses of herbaceous and woody plants to experimental manipulations of precipitation intensity in a cold, semi-arid ecosystem in Utah, USA. In this experiment, precipitation was collected and redeposited as fewer, larger events with total annual precipitation kept constant across treatments. Results from the first two growing seasons revealed that more intense events ‘pushed’ …

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Digitization Of Entomological Collections At Usu, Eastern Using Scan (Symbiota Collections Of Arthropods Network) Data Portal And Seek! Inaturalist App, Alexandra Cartwright Dec 2021

Digitization Of Entomological Collections At Usu, Eastern Using Scan (Symbiota Collections Of Arthropods Network) Data Portal And Seek! Inaturalist App, Alexandra Cartwright

Fall Student Research Symposium 2021

Pollinators, including bees, provide valuable ecosystem services for native plants and agricultural species. Phenology, or the timing of biological events such as flowering of plants, is changing as a result of climate change. The digitization of specimens allows for insights into species distributions, seasonality, and phenology in 60-70-year-old collections. The entomological collection at Utah State University, Eastern houses approximately 3,000 individual specimens and over 100 bees. The oldest specimens date from 1953, many from the 1960s, 70s, & 80s and the majority of specimens are from Carbon and Emery Counties. Digitization of entomological collections can provide: species distributions: Which species …

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True Grit (1969) And Feminism: How It Succeeds And Why We Should Expect Better, Courtney Isom Dec 2021

True Grit (1969) And Feminism: How It Succeeds And Why We Should Expect Better, Courtney Isom

Fall Student Research Symposium 2021

Hollywood Westerns are certainly not renowned for their contribution to feminist plots or characters, but True Grit (1969) is one of the more forward thinking movies with respect to women’s roles. However, the movie still portrays traditional power structures of patriarchy that undermine the female character’s autonomy. Looking at this film through the lens of both Critical Rhetoric and a Gender Diversity Perspective allows us to see the nuances of Mattie Ross' stand against oppressive traditional roles, while also examining the ways in which she is still dominated by discursive patriarchal practices. Celeste Condit’s gender diversity perspective encourages ditching traditional …

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Discovering Virally Encoded Proteins That Block Type Iv Crispr Immune Systems, Andrew Williams Dec 2021

Discovering Virally Encoded Proteins That Block Type Iv Crispr Immune Systems, Andrew Williams

Fall Student Research Symposium 2021

Bacteria and the viruses that infect them have been at war from the beginnings of life until today. Due to selective pressure from viral infection, bacteria have evolved various biological defense systems, including CRISPR-Cas systems that use a genetic memory of previous viral encounters to protect against future invasions. However, recently it has been shown that viruses have evolved counter-strategies to evade CRISPR systems. Virally encoded proteins called anti-CRISPRs use a variety of mechanisms to block the activity of CRISPR immune systems in order to infect bacterial cells. The Jackson lab at USU recently showed that a Type IV-A CRISPR-Cas …

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Universal Healthcare: Is It The Future?, Izzy Wappett Dec 2021

Universal Healthcare: Is It The Future?, Izzy Wappett

Fall Student Research Symposium 2021

About 8.5% of the United States population has no form of healthcare. The rest of the population either has a form of public or private insurance given to them by the government, private insurers, or employers. But there are countries worldwide that have systems where every citizen has healthcare. This is called universal healthcare. Universal Healthcare has shown to be more effective because it portrays healthcare as less of a privilege and more of a right to all. But many Americans view this kind of system as controlling and a system that takes away your freedom. But as studies and …

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Identification And Isolation Of Halotolerant Endophytes In Ceanothus Velutinus May Lead To Plant Health In Saline Conditions, Katherine Hewitt Dec 2021

Identification And Isolation Of Halotolerant Endophytes In Ceanothus Velutinus May Lead To Plant Health In Saline Conditions, Katherine Hewitt

Fall Student Research Symposium 2021

Plant-microbe relations are integral to plant survival and crop productivity. Part of a plant’s biosphere are endophytes, microbes found between the cells of a plant. Endophytes can be beneficial to help a plant cope with abiotic stressors such as salinity. In Utah, our soils are high in salinity due to topography and climate. Climate change has increased soil salinity across the world, and water availability is becoming scarcer leading agriculture to use more saline sources to irrigate. Thus, salt is a concern for farmers. We aim to identify halotolerant endophytes from Ceanothus velutinus, Snowbrush which is native to the …

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Log Proximity And Moss As Indicators Of Conifer Seedling Abundance In Old-Growth Douglas-Fir/ Hemlock Forests, Isabella Wetzler Dec 2021

Log Proximity And Moss As Indicators Of Conifer Seedling Abundance In Old-Growth Douglas-Fir/ Hemlock Forests, Isabella Wetzler

Fall Student Research Symposium 2021

It is increasingly essential to develop a comprehensive understanding of forest processes so that we may better conserve and maintain our old-growth forests in the face of climate change. In the Pacific Northwest, logs might elevate and remove conifer seedlings from light competition with moss and herbs, but seedlings growing on the forest floor may benefit from log shade. Moss can retain moisture which may result in higher water availability for seedlings, but in droughty conditions the desiccated moss might leave seedlings ‘high and dry’. Logs increase mircrosite heterogeneity, providing cool, moist microclimates for seedlings and protecting them from droughty …

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Characterizing The Mechanisms Of C. Elegans Prmt1 Temperature Dependence, Arianna Towne Dec 2021

Characterizing The Mechanisms Of C. Elegans Prmt1 Temperature Dependence, Arianna Towne

Fall Student Research Symposium 2021

Over time, cellular enzymes evolve through amino acid mutations which allow them to remain functional at temperatures specific to the host organism. This activity may be partially or completely lost when enzymes are removed from their optimal temperature range, as is observed for the C. elegans protein arginine methyltransferase 1 (cPRMT1). This construct demonstrates maximum enzymatic activity at the C. elegans optimum of 20°C, but no activity at 37°C where activity for mammalian PRMT1 variants is observed. Given dysregulation of PRMT1 has been linked to various disease states, we are interested in exploiting the biophysical mechanisms of cPRMT1 temperature dependence …

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Evidence Of Myomir Regulation Of The Pentose Phosphate Pathway During Mechanical Load-Induced Hypertrophy, Taylor Valentino, Vandre C. Figueiredo, C. Brooks Mobley, John J. Mccarthy, Ivan J. Vechetti Jr. Dec 2021

Evidence Of Myomir Regulation Of The Pentose Phosphate Pathway During Mechanical Load-Induced Hypertrophy, Taylor Valentino, Vandre C. Figueiredo, C. Brooks Mobley, John J. Mccarthy, Ivan J. Vechetti Jr.

Physiology Faculty Publications

Many of the molecular and cellular mechanisms discovered to regulate skeletal muscle hypertrophy were first identified using the rodent synergist ablation model. This model reveals the intrinsic capability and necessary pathways of skeletal muscle growth in response to mechanical overload (MOV). Reminiscent of the rapid cellular growth observed with cancer, we hypothesized that in response to MOV, skeletal muscle would undergo metabolic programming to sustain increased demands to support hypertrophy. To test this hypothesis, we analyzed the gene expression of specific metabolic pathways taken from transcriptomic microarray data of a MOV time course. We found an upregulation of genes involved …

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Spatiotemporal Variation Of An Eastern Tropical Pacific Pelagic Community Assessed With Free-Drifting Bruvs, Tyler Stephen Plum Dec 2021

Spatiotemporal Variation Of An Eastern Tropical Pacific Pelagic Community Assessed With Free-Drifting Bruvs, Tyler Stephen Plum

All HCAS Student Capstones, Theses, and Dissertations

Information about pelagic community diversity and ecology generally lags far behind that of coastal communities, and largely derives from fisheries data that do not reflect small and non-target species. We describe spatiotemporal vertebrate species diversity and variability over a 3,486 km2 area of highly productive pelagic marine ecosystem in Pacific Panama using drifting baited remote underwater video stations (BRUVS), a non-invasive fishery-independent sampling technique. We observed 26 taxa from 17 families, including 1 mammal, 3 reptile, 5 elasmobranch, and 17 teleost species. Community assemblages differed on and off the continental shelf and between wet (April – December) and dry …

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An Assessment Of The Diverse Freshwater Turtle Fauna Of Mississippi, Lucas Haralson Dec 2021

An Assessment Of The Diverse Freshwater Turtle Fauna Of Mississippi, Lucas Haralson

Master's Theses

Nestled within the Southeastern United States Turtle Priority Area, Mississippi boasts impressive freshwater turtle diversity and is home to 8.6% of extant turtle species. Despite this impressive richness, few studies have assessed freshwater turtle assemblages in this hotspot of aquatic diversity. This research aimed to elucidate the distributions and abundances of freshwater turtle species through a statewide investigation of all major river drainages of the state. Using baited hoop nets (90 cm and 120 cm diameter), turtles were collected, identified to species and sex, and measured, before being released. Turtle assemblages were assessed in both lotic and lentic environments from …

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Understanding Factors Influencing Seed Germination Of Seven Wildflowers In Sub-Alpine Ecosystems, Alyssa Joy Brown Dec 2021

Understanding Factors Influencing Seed Germination Of Seven Wildflowers In Sub-Alpine Ecosystems, Alyssa Joy Brown

Theses and Dissertations

This thesis explores the seed germination of seven wildflowers native to sub-alpine ecosystems. Wildflowers are an essential functional group in native plant ecosystems. Also known as forbs, these plants offer a myriad of benefits in addition to being aesthetically pleasing. They provide habitats for anthropods and small mammals, support native pollinator populations, and grow well with other plant functional groups (especially perennial grasses and shrubs). Healthy plant communities make use of the limited resources in our native ecosystems, competing with invasive species that can otherwise dominate the landscape. Germination involves the transition from seed to an actively growing plant. Following …

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Investigating The Influence Of Available Drinking Water On Wildlife In Utah's West Desert, Danielle K. Finlayson Dec 2021

Investigating The Influence Of Available Drinking Water On Wildlife In Utah's West Desert, Danielle K. Finlayson

Theses and Dissertations

The availability of water is a limiting resource for many wildlife species in arid and semi- arid environments. Free water is essential for critical life stages for numerous species, including migration, reproduction, survival, and habitat selection. Riparian areas in the desert occur relatively infrequently, but support a disproportionally large percentage of plant and wildlife species found in arid environments. Our study covered two aspects of water use in the west desert of Utah. The first was assessing the impacts of nonnative ungulates (specifically feral horses and cattle) on natural springs, and how they influenced water quality, vegetation, and wildlife diversity …

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Cyanobacteria And Phytoplankton Responses To Nutrients In Deep-Water Montane Reservoirs, Madeleine Paige Malmfeldt Dec 2021

Cyanobacteria And Phytoplankton Responses To Nutrients In Deep-Water Montane Reservoirs, Madeleine Paige Malmfeldt

Theses and Dissertations

Mountains play an important role in providing water resources from snow and ice to downstream urban population centers. In Utah, USA, nearly 86% of the state's population resides in the rapidly growing urban corridor along the Wasatch Front. Water along the Wasatch Front is stored in several deep reservoirs in the Provo River Watershed. Additions of nutrients, into these reservoirs, may stimulate the growth of primary producers (e.g., total phytoplankton and cyanobacteria) potentially attenuating water quality. To determine the influence of nutrients on primary producers in the Provo River's reservoirs, identify whether cyanobacteria are transported downstream, and quantify nutrient thresholds …

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The Scoop On Composting: A Comprehensive Literature Review On Composting With A Focus On Grand Valley State University, Alexandria Snabes Dec 2021

The Scoop On Composting: A Comprehensive Literature Review On Composting With A Focus On Grand Valley State University, Alexandria Snabes

Honors Projects

This comprehensive review discusses the main microbial processes, methods, efficiency strategies, benefits, and drawbacks related to composting. Specifically, anaerobic, aerobic, and intermediate, or cold composting, decomposition processes are defined and assessed. This leads into a discussion of some common methods of composting, both large- and small-scale, which utilize these microbial processes to result in differing advantages and disadvantages. The efficiency of these methods can be increased using strategies that monitor oxygen levels, moisture levels, temperate levels, and overall size. Some benefits of composting discussed include diverting waste from landfills, improving soil nutrition and quality long-term, and increasing plant growth and …

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Inter-Subject Correlation While Listening To Minimalist Music: A Study Of Electrophysiological And Behavioral Responses To Steve Reich’S Piano Phase, Tysen Dauer, Duc T. Nguyen, Nick Gang, Jacek P. Dmochowski, Jonathan Berger, Blair Kaneshiro Dec 2021

Inter-Subject Correlation While Listening To Minimalist Music: A Study Of Electrophysiological And Behavioral Responses To Steve Reich’S Piano Phase, Tysen Dauer, Duc T. Nguyen, Nick Gang, Jacek P. Dmochowski, Jonathan Berger, Blair Kaneshiro

Publications and Research

Musical minimalism utilizes the temporal manipulation of restricted collections of rhythmic, melodic, and/or harmonic materials. One example, Steve Reich’s Piano Phase, offers listeners readily audible formal structure with unpredictable events at the local level. For example, pattern recurrences may generate strong expectations which are violated by small temporal and pitch deviations. A hyper-detailed listening strategy prompted by these minute deviations stands in contrast to the type of listening engagement typically cultivated around functional tonal Western music. Recent research has suggested that the inter-subject correlation (ISC) of electroencephalographic (EEG) responses to natural audio-visual stimuli objectively indexes a state of “engagement,” demonstrating …

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Distribution, Abundance, And Population Genetics Of The Alligator Snapping Turtle (Macrochelys Temminckii) In Mississippi, Luke Pearson Dec 2021

Distribution, Abundance, And Population Genetics Of The Alligator Snapping Turtle (Macrochelys Temminckii) In Mississippi, Luke Pearson

Dissertations

The southeastern United States is a freshwater turtle biodiversity hotspot, second only to southeastern Asia, and this region is inhabited by one of the largest freshwater turtles in the world: the alligator snapping turtle (Macrochelys temminckii). This species was heavily harvested from the 1960’s to the 1980’s for the turtle soup industry, apparently contributing to substantial, range-wide population declines. These declines, coupled with anthropogenic impacts on riverine and floodplain habitats, have led to M. temminckii being petitioned for federal listing under the U.S. Endangered Species Act; it is currently under review by the U.S. Fish and Wildlife Service …

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Granulins In Norm And Neurodegenerative Pathologies, Anukool Bhopatkar Dec 2021

Granulins In Norm And Neurodegenerative Pathologies, Anukool Bhopatkar

Dissertations

Granulins (GRNs) are small, cysteine-rich modules produced from the proteolytic cleavage of the precursor protein called progranulin (PGRN). GRNs are present in the form of seven tandem repeats within the precursor and are known to be produced in the extracellular and in lysosomal environments. In physiology, PGRN and GRNs plays pleiotropic roles such as neuronal growth and differentiation, immunomodulation, wound healing. Recent studies have implicated pathological role for PGRN in Alzheimer disease (AD) and frontotemporal dementia (FTD) but specific mechanism(s) remains unclear. However, potential interactions between GRNs and Ab42 and TDP-43 seem like a plausible underlying mechanism. Studies presented here …

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Dicer Represses Antiviral Innate Immunity Pathways In Mouse Embryonic Stem Cells, Chandan Gurung Dec 2021

Dicer Represses Antiviral Innate Immunity Pathways In Mouse Embryonic Stem Cells, Chandan Gurung

Dissertations

Recent studies have demonstrated that embryonic stem cells (ESCs) are deficient in expressing type I interferons (IFN), the cytokines that play key roles in antiviral responses. However, the underlying molecular mechanisms and biological implications of this finding are poorly understood. In this study, I used a synthetic RNA-based assay that can simultaneously assess multiple forms of antiviral responses in ESCs. Dicer is an enzyme essential for RNA interference (RNAi), which is used as a major antiviral mechanism in invertebrates but not clear in vertebrates. RNAi activity is detected in wild-type ESCs but is abolished in Dicer knockout ESCs (D−/−ESCs) as …

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Aquaporin Expression And Cholesterol Content In Eel Swimbladder Tissue, Victoria Drechsel, Gabriel Schneebauer, Birgit Fiechtner, Christopher P. Cutler, Bernd Pelster Dec 2021

Aquaporin Expression And Cholesterol Content In Eel Swimbladder Tissue, Victoria Drechsel, Gabriel Schneebauer, Birgit Fiechtner, Christopher P. Cutler, Bernd Pelster

Department of Biology Faculty Publications

Leakiness of the swimbladder wall of teleost fishes must be prevented to avoid diffusional loss of gases out of the swimbladder. Guanine incrustation as well as high concentrations of cholesterol in swimbladder membranes in midwater and deep-sea fish has been connected to a reduced gas permeability of the swimbladder wall. On the contrary, the swimbladder is filled by diffusion of gases, mainly oxygen and CO2, from the blood and the gas gland cells into the swimbladder lumen. In swimbladder tissue of the zebrafish and the Japanese eel, aquaporin mRNA has been detected, and the aquaporin protein has been considered important …

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Element Contamination In Port Everglades – Preparing For Ecological Impacts, Laura White Dec 2021

Element Contamination In Port Everglades – Preparing For Ecological Impacts, Laura White

All HCAS Student Capstones, Theses, and Dissertations

Port dredging is of economic importance worldwide but its impacts to the marine environment through the remobilization of elemental contaminants are not well understood. A massive deepening and widening of Port Everglades, Florida, will begin in 2023. Contaminated sediment disturbed during the dredging process could be released and prove to be harmful to three coral reef tracks located beginning 1.5 miles away from the port. This study focused on identifying and quantifying 14 different trace elements: arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), mercury (Hg), lead (Pb), manganese (Mn), molybdenum (Mo), nickel (Ni), selenium (Se), tin (Sn), …

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Meta-Analyses Identify Dna Methylation Associated With Kidney Function And Damage, Pascal Schlosser, Adrienne Tin, Pamela R Matias-Garcia, Chris H L Thio, Roby Joehanes, Hongbo Liu, Antoine Weihs, Zhi Yu, Anselm Hoppmann, Franziska Grundner-Culemann, Josine L Min, Adebowale A Adeyemo, Charles Agyemang, Johan Ärnlöv, Nasir A Aziz, Andrea Baccarelli, Murielle Bochud, Hermann Brenner, Monique M B Breteler, Cristian Carmeli, Layal Chaker, John C Chambers, Shelley A Cole, Josef Coresh, Tanguy Corre, Adolfo Correa, Simon R Cox, Niek De Klein, Graciela E Delgado, Arce Domingo-Relloso, Kai-Uwe Eckardt, Arif B Ekici, Karlhans Endlich, Kathryn L Evans, James S Floyd, Myriam Fornage, Lude Franke, Eliza Fraszczyk, Xu Gao, Xīn Gào, Mohsen Ghanbari, Sahar Ghasemi, Christian Gieger, Philip Greenland, Megan L Grove, Sarah E Harris, Gibran Hemani, Peter Henneman, Christian Herder, Steve Horvath, Lifang Hou, Mikko A Hurme, Shih-Jen Hwang, Marjo-Riitta Jarvelin, Sharon L R Kardia, Silva Kasela, Marcus E Kleber, Wolfgang Koenig, Jaspal S Kooner, Holly Kramer, Florian Kronenberg, Brigitte Kühnel, Terho Lehtimäki, Lars Lind, Dan Liu, Yongmei Liu, Donald M Lloyd-Jones, Kurt Lohman, Stefan Lorkowski, Ake T Lu, Riccardo E Marioni, Winfried März, Daniel L Mccartney, Karlijn A C Meeks, Lili Milani, Pashupati P Mishra, Matthias Nauck, Ana Navas-Acien, Christoph Nowak, Annette Peters, Holger Prokisch, Bruce M Psaty, Olli T Raitakari, Scott M Ratliff, Alex P Reiner, Sylvia E Rosas, Ben Schöttker, Joel Schwartz, Sanaz Sedaghat, Jennifer A Smith, Nona Sotoodehnia, Hannah R Stocker, Silvia Stringhini, Johan Sundström, Brenton R Swenson, Maria Tellez-Plaza, Joyce B J Van Meurs, Jana V Van Vliet-Ostaptchouk, Andrea Venema, Niek Verweij, Rosie M Walker, Matthias Wielscher, Juliane Winkelmann, Bruce H R Wolffenbuttel, Wei Zhao, Yinan Zheng, Marie Loh, Harold Snieder, Daniel Levy, Melanie Waldenberger, Katalin Susztak, Anna Köttgen, Alexander Teumer Dec 2021

Meta-Analyses Identify Dna Methylation Associated With Kidney Function And Damage, Pascal Schlosser, Adrienne Tin, Pamela R Matias-Garcia, Chris H L Thio, Roby Joehanes, Hongbo Liu, Antoine Weihs, Zhi Yu, Anselm Hoppmann, Franziska Grundner-Culemann, Josine L Min, Adebowale A Adeyemo, Charles Agyemang, Johan Ärnlöv, Nasir A Aziz, Andrea Baccarelli, Murielle Bochud, Hermann Brenner, Monique M B Breteler, Cristian Carmeli, Layal Chaker, John C Chambers, Shelley A Cole, Josef Coresh, Tanguy Corre, Adolfo Correa, Simon R Cox, Niek De Klein, Graciela E Delgado, Arce Domingo-Relloso, Kai-Uwe Eckardt, Arif B Ekici, Karlhans Endlich, Kathryn L Evans, James S Floyd, Myriam Fornage, Lude Franke, Eliza Fraszczyk, Xu Gao, Xīn Gào, Mohsen Ghanbari, Sahar Ghasemi, Christian Gieger, Philip Greenland, Megan L Grove, Sarah E Harris, Gibran Hemani, Peter Henneman, Christian Herder, Steve Horvath, Lifang Hou, Mikko A Hurme, Shih-Jen Hwang, Marjo-Riitta Jarvelin, Sharon L R Kardia, Silva Kasela, Marcus E Kleber, Wolfgang Koenig, Jaspal S Kooner, Holly Kramer, Florian Kronenberg, Brigitte Kühnel, Terho Lehtimäki, Lars Lind, Dan Liu, Yongmei Liu, Donald M Lloyd-Jones, Kurt Lohman, Stefan Lorkowski, Ake T Lu, Riccardo E Marioni, Winfried März, Daniel L Mccartney, Karlijn A C Meeks, Lili Milani, Pashupati P Mishra, Matthias Nauck, Ana Navas-Acien, Christoph Nowak, Annette Peters, Holger Prokisch, Bruce M Psaty, Olli T Raitakari, Scott M Ratliff, Alex P Reiner, Sylvia E Rosas, Ben Schöttker, Joel Schwartz, Sanaz Sedaghat, Jennifer A Smith, Nona Sotoodehnia, Hannah R Stocker, Silvia Stringhini, Johan Sundström, Brenton R Swenson, Maria Tellez-Plaza, Joyce B J Van Meurs, Jana V Van Vliet-Ostaptchouk, Andrea Venema, Niek Verweij, Rosie M Walker, Matthias Wielscher, Juliane Winkelmann, Bruce H R Wolffenbuttel, Wei Zhao, Yinan Zheng, Marie Loh, Harold Snieder, Daniel Levy, Melanie Waldenberger, Katalin Susztak, Anna Köttgen, Alexander Teumer

Student and Faculty Publications

Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. to extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. …

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