Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Neuromuscular Development And Phenotypic Variation In Zebrafish Models Of Dystroglycanopathy, Erin Bailey
Neuromuscular Development And Phenotypic Variation In Zebrafish Models Of Dystroglycanopathy, Erin Bailey
Electronic Theses and Dissertations
Skeletal muscle is highly conserved among vertebrates and is essential for strength and locomotion. This tissue becomes integrated with the skeletal system via tendons at the myotendinous junction and with the nervous system at the neuromuscular junction. Both of these specialized junctions are rich in extracellular matrix, a protein scaffold that occupies the extracellular space of cells. Skeletal muscle is also highly plastic and can grow in size (hypertrophy) or lose mass (atrophy) in response to genetic or environmental cues. Muscle atrophy is found in individuals battling a number of neuromuscular conditions, including muscular dystrophy. Muscular dystrophies are a suite …
Determining The Key Residues For Capsule Production In The Gbs Cpsa Protein, Anna Struba
Determining The Key Residues For Capsule Production In The Gbs Cpsa Protein, Anna Struba
Honors College
Streptococcus agalactiae (GBS) is a common bacterium found commensally in the vaginal mucosa of healthy adults. GBS also causes severe infection in neonates, often leading to meningitis, which can cause lifelong health consequences including impaired hearing and seizures. Infection of newborns mainly arises from a colonized mother, either before birth through ascending infection or during labor. Ascending infection, where the bacteria travel to the fetus from the vaginal mucosa, is especially concerning as it can lead to loss of pregnancy or premature birth. The most common method of neonatal GBS disease prevention is antibiotic prophylaxis during delivery, though this method …
The Effect Of Embryonic Arsenic Exposure On The Sensorimotor Behavior Of Zebrafish (Danio Rerio), Laura Paye
The Effect Of Embryonic Arsenic Exposure On The Sensorimotor Behavior Of Zebrafish (Danio Rerio), Laura Paye
Honors College
The goal of this study is to determine the effect of arsenic exposure on vision in zebrafish (Danio rerio). The optic system of D. rerio is ideal for examining visual defects. Their eyes are similar to eyes of humans and can therefore be useful models in studies of human eye disease. Their optic system functions similarly to humans, so it is beneficial to observe how zebrafish are affected by contaminants in the environment. Arsenic is ubiquitous in groundwater, due to its natural presence in bed rock, but is elevated by human activities. In order to see any …