Life Sciences Commons^™

Frost450, A Novel Microtubule Targeting Agent: Resistance And Cross-Resistance In An Ovarian Cancer Cell Line, Jonathan Chancellor Fox

Undergraduate Honors Theses

Drug resistance remains problematic for chemotherapy treatments. As primary treatment strategies tend to lose potency against cancer, there is a need for treatment options that overcome drug resistance mechanisms. FROST450, a novel microtubule destabilizing agent, has proven anticancer effects that overcome taxane and multidrug resistance. However, to better understand the clinical potential of FROST450, in this study we examine the mechanisms and implications of acquired FROST450 resistance in an A2780 ovarian cancer cell line. Results indicate FROST450 resistance is associated with increased mitochondrial respiration and with changes in gene sequence or expression level of proteins associated with microtubules, and that …

To Dust You Shall Return: A Theological Argument For The Human Compost Movement, Sydney N. Ederer

Undergraduate Honors Theses

This research paper analyzes Catholic, Daoist, and Jewish beliefs on death, the body, the soul, afterlife, and after death rituals in order to build a connection between these beliefs and human composting practices. It uses these three religious traditions to find support for and recognize potential opposition against the human compost movement. These conclusions are in turn used to make a claim for human composting. Thorough research and a careful analysis of religious beliefs and traditions surrounding death and the body provides theological support for human composting as a recommended method for body disposal after death. Therefore, this research is …

Identifying The 5’End Of The Camta1 Genes In Zebrafish, Morgan Fronk

Undergraduate Honors Theses

Congenital heart diseases (CHDs) are a significant cause of infant death and are frequently caused by mutations in transcription factors. Camta1 (calmodulin binding transcription activator 1) is a transcription factor that has been proposed as a modulator in embryonic heart development and a possible cause of CHDs. The only other known member of its family in vertebrates is involved in activating a hypertrophy gene program in adult heart failure. Unlike camta2, camta1 is expressed in the embryonic heart during heart looping. However, few studies have been done on camta1. In zebrafish, there are two camta1 ohnologs (homologs created through …

Synthesis Of Candidate Natural Killer T Cell Ligands, Teron Haynie, Shenglou Deng, Paul B. Savage

Undergraduate Honors Theses

Natural Killer T (NKT) cells are a subset of T cells that express an invariant T cell receptor (TCR) that recognizes lipid antigens in context of the CD1d molecule. CD1d presents both exogenous and endogenous glycolipids on the surface of antigen presenting cells (APCs). Multiple exogenous lipids capable of NKT cell stimulation have been characterized, but confirmed endogenous ligands are relatively few in number. Recently, a-galactosylceramides were shown to be endogenous NKT cell ligands. We have observed that a-galactosylceramides cyclize in acidic conditions. Since the biosynthetic pathway of lipid presentation via CD1d likely passes through the acidic lysosome, we propose …

Self-Regulation, Threat Perception, And Inhibitory Control: An Fmri Investigation Of Children With Adhd, Erin Kaseda

Undergraduate Honors Theses

This thesis examines the role of perceived parental support on adolescents aged 12-19 who have been diagnosed with attention-deficit/hyperactivity disorder (ADHD). Specifically, the study focused on inhibitory control, one form of cognitive executive control often implicated in ADHD, in three ways: first, through the use of a Go/No-Go task during a functional MRI scan of the brain; second, through the use of a neuropsychological cognitive battery using the NIH Toolbox; and third, through a qualitative interview that examined self-control in school and home contexts. Contrary to the initial hypothesis, parental support was found to be negatively correlated with inhibitory control …

Plant Functional Groups And Success In A Changing Environment: Modeling Physiological Niches Of Colorado Plateau Plants, Anne Thomas

Undergraduate Honors Theses

Quantifying the environmental and physiological niches of plant species is crucial to predicting their sensitivity to global change, and aggregating plant species by functional type is fundamental both to ecological theory and to the practicality of large-scale efforts to predict the consequences of global change. However, traditional functional types are not always predictive of individual species’ responses to change. Here, an inverse species distribution modeling approach is used to identify functionally similar species based on physiological niche in order to better anticipate the consequences of climate change on the Colorado Plateau, USA. The Colorado Plateau is a semiarid region particularly …

Genomewide Evaluation Of Cis-Elements And Cognate Transcription Factors In Nicotiana Attenuata Predicts 27 Unique Transcription Factor-Binding Site Pairs, Ashton Omdahl

Undergraduate Honors Theses

Nicotiana attenuata has been widely studied for its ecological plant-herbivore relationships and response to environmental stress. The jasmonate signaling pathway regulated by jasmonate ZIM-domiain (JAZ) repressor proteins that modulate defense response levels has been of particular focus in this research. While our understanding of the genes associated with defense response and their regulation continues to expand, the transcriptional regulation of these genes is largely uncharacterized. In an effort to provide insight into these relationships, we performed genomewide analysis of transcript level data in order to predict transcription factors (TFs), their respective binding sites (TFBS), and the genes they regulate. We …

The Physiological Effects Of Exercise On California Yellowtail (Seriola Dorsalis) White Muscle, Julie Giannini

Undergraduate Honors Theses

California yellowtail (Seriola dorsalis) is a species of ray-finned fish that demonstrates a significant increase in muscle mass in response to sustained exercise at optimal swimming speed. In this study, three groups of yellowtail have been analyzed for a 6-month period to determine if the length of exercise affects white muscle fiber development and if these changes persist when the exercised fish have been returned to a normal “resting” condition. Gene analysis was performed to test if MyoD, a myogenic regulatory factor, was upregulated in response to exercise. To test these questions, the groups compared included a control …

Effect Of Adult Chemical Cues On Molting Of Fiddler Crab Megalopae In Low Salinity Seawater, Sydney Rilum

Undergraduate Honors Theses

Three species of fiddler crabs, Uca minax, U. pugnax, and U. pugilator, are commonly found in estuaries along the Atlantic coast, each with distinct adult habitats differing in salinity and sediment grain size. Prior research has found evidence for larvae exhibiting selective settlement; however, the degree to which and the method by which they choose their species-appropriate habitat to settle in is still unknown. Additionally, a recent study determined that chemical cues from adult crabs stimulate molting in field-caught fiddler crab megalopae, as previously determined in lab-reared megalopae; however, in 35 ppt seawater, few U. minax molted. …

Social Play Predicts Docility In Juvenile Ground Squirrels, James Hurst-Hopf, Scott L. Nunes

Undergraduate Honors Theses

We evaluated the hypothesis that social play behavior influences the development of temperament in young animals, using docility as a measure of temperament. We observed the play behavior of juvenile Belding’s ground squirrels (Urocitellus beldingi) during the developmental period in which play primarily occurs, and conducted behavioral tests measuring docility at the beginning and end of the play interval. Tests involved handling squirrels and recording their responses. Body mass was a reliable predictor of docility at the beginning of the play period. Rates of social play and maximum distances traveled from the natal burrow during the play interval …

Planktonic Diatom Species Succession In San Francisco Bay (September 2015 - December 2017), Theresa Keith

Undergraduate Honors Theses

Since Hutchinson first described the “Paradox of the Plankton” in 1961, research has been done to determine how and why the coexistence of so many different species of phytoplankton is possible. A critical part of this question is species succession, or how the assemblage of phytoplankton in a region changes over time. This study examines the succession of planktonic diatoms in San Francisco Bay, CA (USA) from September 2015 through December 2017 using phytoplankton samples and environmental data. Periodic sampling was conducted at a site in the Golden Gate Strait and taxa were identified using light microscopy and scanning electron …

College Students’ Understandings Of, Perceptions Towards, And Usage Of Canned Foods Based On Exposure To Canned Foods During Childhood, Robert H. Drury, Lora Beth Brown, Pauline Williams, Dennis Eggett, Rickelle Richards

Undergraduate Honors Theses

ABSTRACT

Objective: To evaluate if frequent usage of canned foods in childhood households affected college students’ current understandings of, perceptions towards, and usage of canned foods.

Methods: A secondary data analysis was conducted based on data collected from students who completed The Perceptions and Use of Canned Foods questionnaire. ANOVA statistics were used to make comparisons between students exposed (ECF; n=65) and not exposed (NECF; n=237) to canned foods during childhood.

Results: Compared with NECF, the ECF more strongly agreed that canned foods counted towards United States’ dietary recommendations (p

Conclusions and Implications: Frequent usage of canned foods during childhood …

Analysis Of Gut Microbiota From Aedes Albopictus Mosquitoes Collected In Central Illinois, Megan E. Cooper

Undergraduate Honors Theses

Aedes albopictus, Asian tiger mosquitoes, are vectors of a wide number of human viral diseases including, West Nile virus, Dengue virus, Chikungunya virus and (recently) Zika virus. A large body of evidence has suggested that microbiomes of mosquito midguts are closely associated with specific mosquito life processes such as nutrition, reproduction, aggregation and defense against toxins. In this study we characterize the bacterial flora of the midguts of adult female Ae. albopictus collected from woodlots and residential areas in Champaign and Coles Counties of Central Illinois (40 samples in each category). After extraction of DNA from dissected midguts, we …

Determining The Physiological And Behavioral Aspects Of Salinity Tolerance In The Asian Clam, Corbicula Fluminea, John Roden

Undergraduate Honors Theses

The Asian clam, Corbicula fluminea, is an invasive bivalve species that now occurs through most of the lower 48 United States. While a significant degree of salinity tolerance has been observed in C. fluminea, owing to its estuarine lineage, the physiological and behavioral responses to changes in salinity by these organisms are not completely understood. It was hypothesized that Corbicula would initially avoid elevated salinity levels (>1 g/L) behaviorally through valve closure, but would eventually have to open to dispel anaerobic waste products and deal with the salinity. To explore this, Corbicula were collected and put through …

Landscape Foundations: A Practical & Technical Guide To Landscape Maintenance, Marco Crosland

Undergraduate Honors Theses

Many homeowners struggle to maintain healthy landscapes. Often, they simply don’t understand basic principles that, if followed, would make a significant difference in the health and appearance of their landscape. The hope of Landscape Foundations is to help homeowners maintain healthy and excellent landscapes by teaching these “correct principles”.

What makes Landscape Foundations different than other landscape guides is that it brings in current research and explains it in a simple way. This guidebook provides pictures and additional resources to explain landscape maintenance principles. It teaches both the practical and technical sides.

Landscape Foundations is written for both beginners and …

Testing The Potential Of Novel Grain Crop Cultivation In Rural Malawi During The Dry Season Through Irrigation And Soil Modification, Jessica Truman

Undergraduate Honors Theses

This research project studied the germination and growth rates of oat and quinoa crops in Mtalimanja, Malawi. This project was part of a larger effort by General Mills and Brigham Young University researchers to increase the diversity and nutrient content of crops in impoverished countries worldwide. It was conducted from May to August 2017 during Malawi’s dry season. Tetraploid oats and quinoa, both modified to increase the protein content of harvested grains, were planted under three different soil conditions: unamended soil, soil mixed with composted chicken litter, and soil with surface-applied granular fertilizer. The research plots were watered daily except …

Statistics And Biomechanics: An Interdisciplinary Evaluation Of The Mathematical, Practical, And Athletic Applications Of Principal Component Analysis, Sydney Grace Davis

Undergraduate Honors Theses

Excerpt from Introduction

Coaches and athletes around the world are in constant pursuit of improving their athletic performance. For some, a routine amount of weight lifting, cardiovascular exercise, agilities and flexibility training with gradual advancement may be enough to see growth. However, many are not satisfied and turn to in-depth analyses of their techniques in order to measure their progress. After an intense workout or competition, coaches spend time breaking down athletic performances based on major movements. By compartmentalizing these activities, they can identify which motions are efficient and which ones hinder fluid motion. From this evaluation and discernment, athletes …

Crash And Burnout: The Sophomore Slump In College Athletics, Jessica Ferguson

Undergraduate Honors Theses

This study analyzed and compared the severity of performance slumps of collegiate student-athletes in general and across academic years. The factors examined with performance slumps included athlete burnout, academic burnout, relationship satisfaction, and grade point averages. The first hypothesis was that reduced accomplishment scores from the athlete burnout questionnaire would indicate the severity of performance slumps. The results did not support the hypothesis. The second hypothesis was that the severity of performance slumps would positively correlate with academic burnout and negatively correlate with relationship satisfaction. The results supported this hypothesis. The third hypothesis was that student-athletes who experienced a performance …

Economic Growth And Changes In Forested Areas In Southeast Asia: Is Environmental Kuznets Curve Still Relevant?, Lan Thi Ngoc Nguyen

Undergraduate Honors Theses

The environmental history of the twentieth century in Southeast Asia reveals tremendous loss of forested areas as a consequence of unprecedented economic transformations and unrestrained globalization. Featuring some of the world’s fastest-growing economies, Southeast Asia has been experiencing fundamental changes in its economic structure, sociopolitical institutions, and the rate of natural resources extraction and depletion, including deforestation. This study reexamines evidence of the (EKC) hypothesis in light of the deforestation the above region experienced over the period 1990-2013. We use the change in forest cover as an indicator for environmental degradation. A panel co-integration approach is invoked to investigate the …