Life Sciences Commons^™

Uric Acid Levels In Relation To Progression Of Multiple Sclerosis, Alexander A. Gosch, Mary F. Davis, Joshua C. Denny

Library/Life Sciences Undergraduate Poster Competition 2017

Multiple sclerosis (MS) is a neurodegenerative disease caused by demyelination in the central nervous system. In previous studies, serum uric acid (UA) levels have been implied as a useful biomarker in understanding MS disease progression and development. The majority of previous studies have found MS patients have a lower UA level than healthy controls, however some studies have found higher UA levels with MS patients. Previous studies have compared UA levels between subtypes of MS, but have not produced conclusive data. To better understand the correlation between UA levels and MS patients, we compared UA levels between our set of …

Frémont Island: Great Salt Lake, Utah, Stanley L. Welsh, Dale Gardner, Steve Durtschi

Books by Faculty of the Monte L. Bean Life Science Museum

Abstract

This account is based mainly on two historical records of pioneering attempts that reached Frémont Island, i.e., Report of the Exploring Expeditions to the Rocky Mountains in the year 1842, and to Oregon and Northern California in the years 1843-‘44, by Brevet Captain J. C. Frémont of the Topographical Engineers Under the orders of Co. J. J. Abert, Chief of the Topographical Bureau. Printed by order of the Senate of the United States. Washington: Gales and Seaton Printers, 1845, and especially pages 151–159 of that report, as presented in narrative form in pages 43–47 of the John Charles …

Neural Changes Associated With Rewards And Punishment Following Ego Depletion Or Boredom, Travis Z. Johnson, Michael Larson, Marina Milyavskaya, Michael Inzlicht

FHSS Mentored Research Conference

Our brain power is exhaustible. We are constantly trying to find ways to perform at our highest levels. There has been research that has shown that willpower--the capacity to exert self-control--is a limited resource that is depleted after exertion of the brain. Many studies have shown the negative effect that depletion has on daily decisions. Depletion can influence our day-to-day choices and actions in a variety of important ways. The neural mechanisms for ego-depletion are relatively unknown so our purpose is to measure the effects of ego-depletion, and then test ways that it can be decreased or reversed, thus finding …

Treatment Of Diabetic Neuropathy With Nitric Oxide Gel, Daniel R. Lathen, David Walton, Yukino Strong, Jeff Ward, Conner Sugrue, Jonathan Trout, Devin Vanderwood, Alonzo Cook Ph.D.

FHSS Mentored Research Conference

Our study investigates a novel therapy to address a vascular factor that contributes to the development of diabetic peripheral neuropathy (DPN) using five experimental groups of a mouse model that spontaneously develops diabetes. The compound under investigation is a nitric oxide (NO)-donating topical gel which has potential as a treatment for preventing and treating DPN.

Pams: A Growing Field In Pharmacological Drug Development, Marcel Hall, J. Kolb, B. Todd Jr., D. Pugh, B. Vance, B. Klienstuber, R. Drecketts, Doris Jackson, H. R. Arias, S. N. Sudweeks

FHSS Mentored Research Conference

Positive Allosteric Modulators (PAMs) are a growing field in pharmacology. PAM-5 and genisteincause acetylcholine (ACh) to elicit larger currents on nicotinic acetylcholine receptors (nAChRs) without activating the channel themselves. In effect, PAMs increase the amplitude of currents at a synapse without altering the normal firing rate of the neurons.

Novel Pharmacological Target: Characterization Of A3b2 Nachrs Expressed In Xenopus Laevis Oocytes, Doris Jackson, Marcel Hall, J. Kolb, B. Todd Jr., D. Pugh, B. Vance, B. Klienstuber, R. Drecketts, S. N. Sudweeks

FHSS Mentored Research Conference

We have identified two subtypes of the novel a3b2 nicotinic acetylcholine receptor (nAChR) found within interneurons of the hippocampus. This novel receptor may be a valuable pharmacological target in drug development for disease such as Alzheimer’s disease (AD) which is largely characterized by degeneration of the hippocampus.