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Full-Text Articles in Life Sciences
Nicotinamide Is An Endogenous Agonist For A C. Elegans Trpv Osm-9 And Ocr-4 Channel, A. Upadhyay, A. Pisupati, T. Jegla, Matthew Crook, K. J. Mickolajczyk, M. Shorey, L. E. Rohan, K. A. Billings, M. M. Rolls, W. O. Hancock, W. Hanna-Rose
Nicotinamide Is An Endogenous Agonist For A C. Elegans Trpv Osm-9 And Ocr-4 Channel, A. Upadhyay, A. Pisupati, T. Jegla, Matthew Crook, K. J. Mickolajczyk, M. Shorey, L. E. Rohan, K. A. Billings, M. M. Rolls, W. O. Hancock, W. Hanna-Rose
Biology Faculty Publications
TRPV ion channels are directly activated by sensory stimuli and participate in thermo-, mechano- and chemo-sensation. They are also hypothesized to respond to endogenous agonists that would modulate sensory responses. Here, we show that the nicotinamide (NAM) form of vitamin B3 is an agonist of a Caenorhabditis elegans TRPV channel. Using heterologous expression in Xenopus oocytes, we demonstrate that NAM is a soluble agonist for a channel consisting of the well-studied OSM-9 TRPV subunit and relatively uncharacterized OCR-4 TRPV subunit as well as the orthologous Drosophila Nan-Iav TRPV channel, and we examine stoichiometry of subunit assembly. Finally, we show that …
Reduced Leukocyte Infiltration In Absence Of Eosinophils Correlates With Decreased Tissue Damage And Disease Susceptibility In Δdblgata Mice During Murine Neurocysticercosis, P. K. Mishra, Q. Li, L. E. Munoz, Chris A. Mares, E. G. Morris, J. M. Teale, A. E. Cardona
Reduced Leukocyte Infiltration In Absence Of Eosinophils Correlates With Decreased Tissue Damage And Disease Susceptibility In Δdblgata Mice During Murine Neurocysticercosis, P. K. Mishra, Q. Li, L. E. Munoz, Chris A. Mares, E. G. Morris, J. M. Teale, A. E. Cardona
Biology Faculty Publications
Neurocysticercosis (NCC) is one of the most common helminth parasitic diseases of the central nervous system (CNS) and the leading cause of acquired epilepsy worldwide. NCC is caused by the presence of the metacestode larvae of the tapeworm Taenia solium within brain tissues. NCC patients exhibit a long asymptomatic phase followed by a phase of symptoms including increased intra-cranial pressure and seizures. While the asymptomatic phase is attributed to the immunosuppressive capabilities of viable T. solium parasites, release of antigens by dying organisms induce strong immune responses and associated symptoms. Previous studies in T. solium-infected pigs have shown that the …
Pharmaceutical Inhibition Of Mtor In The Common Marmoset: Effect Of Rapamycin On Regulators Of Proteostasis In A Non-Human Primate, M. Lelegren, Y. Liu, Corinna N. Ross, S. Tardif, A. B. Salmon
Pharmaceutical Inhibition Of Mtor In The Common Marmoset: Effect Of Rapamycin On Regulators Of Proteostasis In A Non-Human Primate, M. Lelegren, Y. Liu, Corinna N. Ross, S. Tardif, A. B. Salmon
Biology Faculty Publications
Background: Inhibition of mechanistic target of rapamycin (mTOR) has emerged as a viable means to lengthen lifespan and healthspan in mice, although it is still unclear whether these benefits will extend to other mammalian species. We previously reported results from a pilot experiment wherein common marmosets (Callithrix jacchus) were treated orally with rapamycin to reduce mTOR signaling in vivo in line with previous reports in mice and humans. Further, long-term treatment did not significantly alter body weight, daily activity, blood lipid concentrations, or glucose metabolism in this cohort. Methods: In this study, we report on the molecular consequences of rapamycin …