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Full-Text Articles in Life Sciences
20-Hydroxyecdysone (20e) Primary Response Gene E93 Modulates 20e Signaling To Promote Bombyx Larval-Pupal Metamorphosis, Xi Liu, Fangyin Dai, Enen Guo, Kang Li, Li Ma, Ling Tian, Yang Cao, Guozheng Zhang, Subba Reddy Palli, Sheng Li
20-Hydroxyecdysone (20e) Primary Response Gene E93 Modulates 20e Signaling To Promote Bombyx Larval-Pupal Metamorphosis, Xi Liu, Fangyin Dai, Enen Guo, Kang Li, Li Ma, Ling Tian, Yang Cao, Guozheng Zhang, Subba Reddy Palli, Sheng Li
Entomology Faculty Publications
As revealed in a previous microarray study to identify genes regulated by 20-hydroxyecdysone (20E) and juvenile hormone (JH) in the silkworm, Bombyx mori, E93 expression in the fat body was markedly low prior to the wandering stage but abundant during larval-pupal metamorphosis. Induced by 20E and suppressed by JH, E93 expression follows this developmental profile in multiple silkworm alleles. The reduction of E93 expression by RNAi disrupted 20E signaling and the 20E-induced autophagy, caspase activity, and cell dissociation in the fat body. Reducing E93 expression also decreased the expression of the 20E-induced pupal-specific cuticle protein genes and prevented growth …
Sex Allocation And The Emergence Of Helping In Cooperatively Breeding Species., Josh D Dunn, Teodora Vujicic, Geoff Wild
Sex Allocation And The Emergence Of Helping In Cooperatively Breeding Species., Josh D Dunn, Teodora Vujicic, Geoff Wild
Applied Mathematics Publications
In cooperative breeding systems individuals invest in the reproductive success of others. In this paper, we study the emergence of cooperative breeding systems in which reproductively active breeders receive investment from reproductively non-active helpers. Our goal is to understand how the division of an investment between male and female components of breeder fitness (i.e. the helper sex-allocation strategy) influences the emergence of cooperative breeding itself. Using mathematical models, we arrive at expressions for the inclusive-fitness advantage of helpful behaviour that generalize previous work. These expressions assume an ecologically stable environment, and that breeders make evolutionarily stable sex-allocation decisions. We find …
Bypassing Iron Storage In Endodermal Vacuoles Rescues The Iron Mobilization Defect In The Natural Resistance Associated-Macrophage Protein3natural Resistance Associated-Macrophage Protein4 Double Mutant, Viviane Mary, Magali Schnell Ramos, Cynthia Gillet, Amanda L. Socha, Jerome Giraudat, Astrid Agorio, Sylvain Merlot, Colin Clairet, Sun A. Kim, Tracy Punshon, Mary Lou Guerinot, Sebastien Thomine
Bypassing Iron Storage In Endodermal Vacuoles Rescues The Iron Mobilization Defect In The Natural Resistance Associated-Macrophage Protein3natural Resistance Associated-Macrophage Protein4 Double Mutant, Viviane Mary, Magali Schnell Ramos, Cynthia Gillet, Amanda L. Socha, Jerome Giraudat, Astrid Agorio, Sylvain Merlot, Colin Clairet, Sun A. Kim, Tracy Punshon, Mary Lou Guerinot, Sebastien Thomine
Dartmouth Scholarship
To improve seed iron (Fe) content and bioavailability, it is crucial to decipher the mechanisms that control Fe storage during seed development. In Arabidopsis (Arabidopsis thaliana) seeds, most Fe is concentrated in insoluble precipitates, with phytate in the vacuoles of cells surrounding the vasculature of the embryo. NATURAL RESISTANCE ASSOCIATED-MACROPHAGE PROTEIN3 (AtNRAMP3) and AtNRAMP4 function redundantly in Fe retrieval from vacuoles during germination. When germinated under Fe-deficient conditions, development of the nramp3nramp4 double mutant is arrested as a consequence of impaired Fe mobilization. To identify novel genes involved in seed Fe homeostasis, we screened an …
Viral Sensing Of The Subcellular Environment Regulates The Assembly Of New Viral Replicase Complexes During The Course Of Infection, Peter D. Nagy
Viral Sensing Of The Subcellular Environment Regulates The Assembly Of New Viral Replicase Complexes During The Course Of Infection, Peter D. Nagy
Plant Pathology Faculty Publications
Replication of plus-stranded RNA [(+)RNA] viruses depends on the availability of coopted host proteins and lipids. But, how could viruses sense the accessibility of cellular resources? An emerging concept based on tombusviruses, small plant viruses, is that viruses might regulate viral replication at several steps depending on what cellular factors are available at a given time point. I discuss the role of phospholipids, sterols, and cellular WW domain proteins and eukaryotic elongation factor 1A (eEF1A) in control of activation of the viral RNA-dependent RNA polymerase (RdRp) and regulation of the assembly of viral replicase complexes (VRCs). These regulatory mechanisms might …
Aquatic Macroinvertebrates: Biological Indicators Of Stream Health, Carmen T. Agouridis, Evan T. Wesley, Tyler M. Sanderson, Blake L. Newton
Aquatic Macroinvertebrates: Biological Indicators Of Stream Health, Carmen T. Agouridis, Evan T. Wesley, Tyler M. Sanderson, Blake L. Newton
Agriculture and Natural Resources Publications
Streams are an important part of the landscape. Streams transport water, sediment and energy; provide habitat for aquatic life and support terrestrial life; provide a place for recreation; and in many cases serve as a water supply. The health of streams—or their ability to perform these important functions—is dependent on the conditions of the watersheds which they drain. Changes in land use within a watershed can affect a stream’s health (Figure 1).
An Approach For Determining And Measuring Network Hierarchy Applied To Comparing The Phosphorylome And The Regulome, Chao Cheng, Erik Andrews, Koon-Kiu Yan, Matthew Ung, Daifeng Wang, Mark Gerstein
An Approach For Determining And Measuring Network Hierarchy Applied To Comparing The Phosphorylome And The Regulome, Chao Cheng, Erik Andrews, Koon-Kiu Yan, Matthew Ung, Daifeng Wang, Mark Gerstein
Dartmouth Scholarship
Many biological networks naturally form a hierarchy with a preponderance of downward information flow. In this study, we define a score to quantify the degree of hierarchy in a network and develop a simulated-annealing algorithm to maximize the hierarchical score globally over a network. We apply our algorithm to determine the hierarchical structure of the phosphorylome in detail and investigate the correlation between its hierarchy and kinase properties. We also compare it to the regulatory network, finding that the phosphorylome is more hierarchical than the regulome.
Methyl Farnesoate Plays A Dual Role In Regulating Drosophila Metamorphosis, Di Wen, Crisalejandra Rivera-Perez, Mohamed Abdou, Qiangqiang Jia, Qianyu He, Xi Liu, Ola Zyaan, Jingjing Xu, William G. Bendena, Stephen S. Tobe, Fernando G. Noriega, Subba R. Palli, Jian Wang, Sheng Li
Methyl Farnesoate Plays A Dual Role In Regulating Drosophila Metamorphosis, Di Wen, Crisalejandra Rivera-Perez, Mohamed Abdou, Qiangqiang Jia, Qianyu He, Xi Liu, Ola Zyaan, Jingjing Xu, William G. Bendena, Stephen S. Tobe, Fernando G. Noriega, Subba R. Palli, Jian Wang, Sheng Li
Entomology Faculty Publications
Corpus allatum (CA) ablation results in juvenile hormone (JH) deficiency and pupal lethality in Drosophila. The fly CA produces and releases three sesquiterpenoid hormones: JH III bisepoxide (JHB3), JH III, and methyl farnesoate (MF). In the whole body extracts, MF is the most abundant sesquiterpenoid, followed by JHB3 and JH III. Knockout of JH acid methyl transferase (jhamt) did not result in lethality; it decreased biosynthesis of JHB3, but MF biosynthesis was not affected. RNAi-mediated reduction of 3-hydroxy-3-methylglutaryl CoA reductase (hmgcr) expression in the CA decreased biosynthesis and titers of the three sesquiterpenoids, resulting in …