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Dopamine Signaling In C. Elegans Is Mediated In Part By Hlh-17-Dependent Regulation Of Extracellular Dopamine Levels, Chaquettea M. Felton, Casonya Matese Johnson
Dopamine Signaling In C. Elegans Is Mediated In Part By Hlh-17-Dependent Regulation Of Extracellular Dopamine Levels, Chaquettea M. Felton, Casonya Matese Johnson
Biology Faculty Publications
In Caenorhabditis elegans, the dopamine transporter DAT-1 regulates synaptic dopamine (DA) signaling by controlling extracellular DA levels. In dat-1(ok157) animals, DA is not taken back up presynaptically but instead reaches extrasynpatic sites, where it activates the dopamine receptor DOP-3 on choligeneric motor neurons and causes animals to become paralyzed in water. This phenotype is called swimming-induced paralysis (SWIP) and is dependent on dat-1 and dop-3. Upstream regulators of dat-1 and dop-3 have yet to be described in C. elegans. In our previous studies, we defined a role for HLH-17 during dopamine response through its regulation of the dopamine receptors. Here …