Life Sciences Commons^™

Discovery Of Thienoquinolone Derivatives As Selective And Atp Non-Competitive Cdk5/P25 Inhibitors By Structure-Based Virtual Screening, Arindam Chatterjee, Stephen J. Cutler, Robert J. Doerksen, Ikhlas A. Khan, John S. Williamson

Office for Research Publications and Presentations

Calpain mediated cleavage of CDK5 natural precursor p35 causes a stable complex formation of CDK5/p25, which leads to hyperphosphorylation of tau. Thus inhibition of this complex is a viable target for numerous acute and chronic neurodegenerative diseases involving tau protein, including Alzheimer’s disease. Since CDK5 has the highest sequence homology with its mitotic counterpart CDK2, our primary goal was to design selective CDK5/p25 inhibitors targeting neurodegeneration. A novel structure-based virtual screening protocol comprised of e-pharmacophore models and virtual screening workflow was used to identify nine compounds from a commercial database containing 2.84 million compounds. An ATP non-competitive and selective thieno[3,2- …

Intercellular Cooperation And Competition In Brain Cancers: Lessons From Drosophila And Human Studies, Indrayani Waghmare, Austin Roebke, Mutsuko Minata, Madhuri Kango-Singh, Ichiro Nakano

Biology Faculty Publications

Glioblastoma (GBM) is a primary brain cancer with an extremely poor prognosis. GBM tumors contain heterogeneous cellular components, including a small subpopulation of tumor cells termed glioma stem cells (GSCs). GSCs are characterized as chemotherapy- and radiotherapy-resistant cells with prominent tumorigenic ability. Studies in Drosophila cancer models demonstrated that interclonal cooperation and signaling from apoptotic clones provokes aggressive growth of neighboring tumorigenic clones, via compensatory proliferation or apoptosis induced proliferation. Mechanistically, these aggressive tumors depend on activation of Jun-N-terminal kinase (upstream of c-JUN), and Drosophila Wnt (Wg) in the apoptotic clones. Consistent with these nonmammalian studies, data from several mammalian …

Effects Of Yoga On Arm Volume Among Women With Breast Cancer Related Lymphedema: A Pilot Study, Mary Insana Fisher, Betsy Donahoe-Fillmore, Laura Leach, Colleen O'Malley, Cheryl Paeplow, Tess Prescott, Harold L. Merriman

Physical Therapy Faculty Publications

Lymphedema affects 3–58% of survivors of breast cancer and can result in upper extremity impairments. Exercise can be beneficial in managing lymphedema. Yoga practice has been minimally studied for its effects on breast cancer related lymphedema (BCRL). The purpose of this study was to determine the effect of yoga on arm volume, quality of life (QOL), self-reported arm function, and hand grip strength in women with BCRL. Six women with BCRL participated in modified Hatha yoga 3×/week for 8 weeks. Compression sleeves were worn during yoga sessions. Arm volume, QOL, self-reported arm function, and hand grip strength were measured at …

Exhibition Handlist, Kathleen M. Webb

Supplemental Media: Catalogue, Handlist, Lectures, Events and More

In preparing for Imprints and Impressions, we ran across many interesting words that have fallen out of the general lexicon. With this booklet, we have brought one back: handlist. Dean Kathleen Webb ran across it in a 1944 booklet from the J. Pierpont Morgan Library in New York City. Though the word no longer appears in most new dictionaries, it’s still in the Oxford English Dictionary:

A list of a particular type or category of things, presented in a readily consultable form; esp. a list of the books or manuscripts in a particular place, on a particular subject, etc.; …

Kir Channel Activation Contributes To Onset And Steady-State Exercise Hyperemia In Humans, Anne R. Crecelius, Gary J. Luckasen, Dennis G. Larson, Frank A. Dinenno

Health and Sport Science Faculty Publications

We tested the hypothesis that activation of inwardly rectifying potassium (K_IR) channels and Na⁺-K⁺-ATPase, two pathways that lead to hyperpolarization of vascular cells, contributes to both the onset and steady-state hyperemic response to exercise. We also determined whether after inhibiting these pathways nitric oxide (NO) and prostaglandins (PGs) are involved in the hyperemic response. Forearm blood flow (FBF; Doppler ultrasound) was determined during rhythmic handgrip exercise at 10% maximal voluntary contraction for 5 min in the following conditions: control [saline; trial 1 (T1)]; with combined inhibition of K_IR channels and Na …

How Sensitive Is The Deltoid Moment Arm To Joint Center Changes With Rtsa?, David Walker, Allison Kinney, Aimee Struk, Benjamin J. Fregly, Thomas Wright, Scott Banks

Mechanical and Aerospace Engineering Faculty Publications

The goal of this study was to assess the sensitivity of the deltoid muscle moment arms as a function of joint configuration for an existing RTSA subject. High variations were found for all three deltoid components. Variation over the entire abduction arc was greatest in the anterior and lateral deltoid, while the posterior deltoid moment arm was mostly sensitive to joint center changes early in the abduction arc. Moment arm changes of 10-16mm represent a significant amount of the total deltoid moment arm. This means there is an opportunity to dramatically change the deltoid moments arms through surgical placement of …

Deltoid Moment Arms During Abduction: A Subject-Specific Musculoskeletal Modeling Study In Healthy Shoulders And Shoulders With Rtsa, David Walker, Allison Kinney, Aimee Struk, Benjamin J. Fregly, Thomas Wright, Scott Banks

Mechanical and Aerospace Engineering Faculty Publications

Reverse total shoulder arthroplasty (RTSA) is increasingly used in the United States since approval by the FDA in 2003. RTSA relieves pain and restores mobility in arthritic rotator cuff deficient shoulders. Though many advantages of RTSA have been demonstrated, there still are a variety of complications (implant loosening, shoulder impingement, infection, frozen shoulder) making apparent much still is to be learned how RTSA modifies normal shoulder function. The goal of this study was to assess how RTSA affects deltoid muscle moment generating capacity post-surgery using a subjectspecific computational model driven by in vivo kinematic data.

A Novel Approach To Estimation Of Patient-Specific Muscle Strength, David Walker, Allison Kinney, Benjamin J. Fregly, Thomas Wright, Scott Banks

Mechanical and Aerospace Engineering Faculty Publications

Current modeling techniques have been used to model the Reverse Total Shoulder Arthroplasty (RTSA) to account for the geometric changes implemented after RTSA. Though these models have provided insight into the effects of geometric changes from RTSA these is still a limitation of understanding muscle function after RTSA on a patient-specific basis. The goal of this study sought to overcome this limitation by developing an approach to calibrate patient-specific muscle strength for an RTSA subject.

Herbaceous 2014, Julia I. Chapman, Keith E. Gilland, Ryan W. Mcewan

Data Files: Drew Woods Permanent Plots

Herbaceous vegetation data collected in 2014 at Drew Woods State Nature Preserve in Darke County, OH. Data key is provided in a supplemental file.

Research Exercise: Ud Iet Dayton Most Metro Chef Ten Question Interview

Stander Symposium Projects

Dayton Most Metro (DMM) is an online regional magazine which has created a ten question interview with local chefs. Currently 20 chef interviews have been completed and uploaded onto the website. DMM’s goal is to add to the amount of interviews posted online this spring 2014, but has run out of the manpower required to do so. The goal behind incorporating the Dayton IET 323 team is to aid DMM in accomplishing its goal. Our team will be conducting interviews with a minimum of eight Dayton area chefs which will be featured on the Dayton Most Metro site. In the …

A Computer Based Detection Of Lung Nodules In Chest

Stander Symposium Projects

Lung cancer is the leading cause of cancerous disease in the United States. Lung cancer usually exhibits its presence with the formation of pulmonary nodules. Nodules are round or oval-shaped growth present in the lung. Chest radiographs are used by radiologists to detect and treat such nodules, but nodules are quite difficult to detect with human eye and are sometimes misinterpreted with lesions present. Thus, automated analysis of such data is very essential and would be of valuable help in lung cancer screening. A new Computer Aided Detection (CAD) system in chest radiography is proposed in this paper. The algorithmic …

A Look At Ohio's Past: A Focus On Ordovician And Silurian Period Fossils Found In The Dayton Area

Stander Symposium Projects

Ohio has a rich geologic history involving the Paleozoic era, specifically the Ordovician and Silurian periods of time for the southwestern part of the state. Ohio was once covered with tropical seas, the evidence for which are the marine fossils found in the limestones, dolomites, and shale rocks in the area. This research project involves a comparison of fossils and geological history of Clifton Gorge, Germantown MetroPark and other parks in the Dayton area. This project also includes a guide for educators on how to engage students through the connection of real world experiences at the high school level using …

Can They Ever Feel At Home?: Saudi Student Experiences In Residence Halls

Stander Symposium Projects

Saudi students are choosing to pursue higher education at institutions in the United States at an accelerated rate. As a result, it is essential that administration develop ways to better serve this population. The residence halls at American institutions provide a unique challenge for Saudi students because of certain elements of their culture including religion, gender dynamics, and more. Currently, there is a lack of research on this particular topic. In a one hour semi-structured interviews, participants reflected on their experience in the residence halls as well as provided suggestions for future programming and physical space. Information collected through this …

Related Self-Motives? Examining The Association Between Self-Verification And Self-Handicapping

Stander Symposium Projects

This research examines the association between self-verification and self-handicapping. Self-verification theory states that people tend to seek information verifying how individuals see themselves. Individuals seek verifying feedback about traits or attributes when they are certain about that attribute, regardless of whether the attribute is positive or negative. However, when individuals are uncertain about a particular trait, they tend to engage in a self-presentational strategy called self-handicapping. Self-handicapping is a self-protecting behavior that mitigates the effect of a potential failure that would otherwise be perceived as threatening to one’s sense of self by providing pre-emptive excuses for poor performances. Using data …

Research Exercise: Reading Interventions In Relation To The Ohio Third Grade Guarantee

Stander Symposium Projects

Reading is one of the most critical skills that students learn in their first few years of education. A strong foundation in reading at the early childhood level can promote success in the rest of schooling and beyond. This is especially true for children of poverty; reading abilities and the strong education that follows provide students with opportunities to break the poverty cycle. The importance of reading achievement is a political dimension, as demonstrated by Ohio’s Third Grade Reading Guarantee. This legislation, which has many implications in education, requires that all third grade students who do not pass the Reading …

The Impact Of Exogenous Macro Economic Events On Flyer Fund Stock And Sector Returns

Stander Symposium Projects

A number of academic studies have shown that markets can be "shocked" by macro economic events. A sudden rise in inflation, interest rates, oil prices, just to name a few, can have a material effect on stock prices. In the study we use Bloomberg's Market Factor Model to determine the impact on stock and sector returns for the U.D. Flyer Fund. The Market Factor Model can identify response functions i.e. Betas between S&P 500 stocks and an exogenous variable like interest rates. We will study the impact of rising market volatility (VIX), rising interest rates (10 Yr T-Note) and oil …

Unfamiliar Territory: A Phenomological Study Of International Students Enrolled In A Large Urban Community College

Stander Symposium Projects

International students are choosing community colleges for reasons of affordability, easy access, and as a good place to start their education, especially if English is their second language. There is a deficiency of research surrounding this student population despite an increase in enrollment. With little representation of the ICCS in current literature and with institutions recognizing their value more than ever, an understanding of their experience is needed. This qualitative study sought to explore and understand the shared experience of the international college student enrolled in a large Midwestern urban community college. The method of data collection included personal interviews …

The Themes Of Catholic Social Teaching Integrated Into The Work Of Ud's Center For Catholic Education's (Cce) Urban Child Development Resource Center (Ucdrc)

Stander Symposium Projects

Schools today are challenged to meet the mental health concerns of students due to an emphasis on academic testing and a lack of communication within schools to identify and treat the needs of the students. The needs of the student travel beyond the classroom into the non-academic barriers to learning. The University of Dayton’s Urban Child Development Resource Center (UCDRC), works in five local schools in the Dayton area and strives to help students cope with these non-academic barriers to learning. This study focuses on three of the Seven Themes of Catholic Social Teaching as stated by the United States …

A Geometric Study Of The Discharge Port Used In Scroll Compressors

Stander Symposium Projects

A scroll compression has become the prevalent technology used air-conditioning and refrigeration systems. The compression chamber consists of two spiral shaped vanes that form pairs of chambers. A crankshaft imposes an orbital translation on one of the vanes, which reduces the volume of the chambers, thereby compressing the gas trapped within the chamber. A hole is placed at the center of the fixed spiral. The moving spiral will uncover the hole, which serves as an exhaust port. This project studies the exhaust flow area as a function of crank angle. Additionally, the project assesses the sensitivity of the exhaust flow …

A Social Justice Learning And Living Community Service Project

Stander Symposium Projects

Through a Social Justice Living and Learning Community Project, researchers were given the opportunity to feed numerous families across the Dayton area. They worked with Food bank Inc. to help sort and repackage donated food to give to families in need. The Food bank provides food for approximately 70,000 different people annually.

An Undivided Heart: How Mary Unites What Sin Divides According To John Paul Ii's Theology Of The Body

Stander Symposium Projects

Today, personhood is often threatened by the tendency to divide the human person into two contrasting parts: body and soul. Many times, this causes the human person to be reduced to a disembodied spiritual being or a disposable object rather than a whole person called to love and be loved. In his teachings known as the Theology of the Body, John Paul II uses a personalistic approach to illuminate the human person as the integration of body and soul. Scripturally based, Theology of the Body is the study of God’s reflection in the human body and human sexuality. Using John …

Application Of A Cobalt Porphyrin And Catalyst In Microbial Fuel Cells

Stander Symposium Projects

A microbial fuel cell (MFC) is a renewable energy device in which microorganisms consume organic matters to generate electricity. These devices have potential utility in wastewater treatment facilities to dually clean the water and generate part of the electricity needed for water treatment. The last decade has seen tremendous advancement in MFC technology, but many challenges remain, particularly with improving performance and efficiency of cathodes. The cathode reduces oxygen to water and traditionally has utilized precious metals as the primary catalytic compound. In these studies, the precious metal in the cathode has been replaced with alternative catalysts, cobalt porphyrins. Porphyrins …

Assessing Aesthetic Preferences For Faces With Measures Of Ocular Gaze

Stander Symposium Projects

Though one may assume that the reactions to two nearly identical works of art would be similar, the medium in which art is presented can influence an individual’s perception of the work (Locher et al., 2006). The present study evaluates aesthetic preferences for faces, specifically, relating to those influenced by art; this is done by comparing reactions when viewing classic portraits and photographic renderings of those portraits. Simultaneously portraits and photographs of faces, matched for variables such as gender, artistic medium, ethnicity, face shape, facial hair, hair color, eye color, and facial position (full or profile), are shown to participants …

Research Exercise: Characterization Of Wnt Signaling During Dorsal Versus Ventral Iris-Derived Newt Lens Regeneration

Stander Symposium Projects

There are many animals that have the ability to regenerate different tissues during embryonic stage, but only newts have the ability to regenerate whole organs throughout their entire life. Our primary focus is lens regeneration through transdifferentiation of pigment epithelial cells (PECs). This process has been previously shown to be highly topological, that is, trasdifferentiation always occur from the dorsal iris and never from the ventral iris. In order to understand why we have regenerative and non-regenerative tissues in dorsal and ventral iris, respectively, we examined the role and expression of several genes. My research aimed to discover the potential …

Community Residential Energy Reduction

Stander Symposium Projects

This research evaluates the effectiveness of residential energy reduction programs aimed at cost effective, collective action. One of these energy reduction programs is Dropoly.com, an online game developed by the University of Dayton that aims to connect neighbors and allow them to compete against one another. The guiding question behind the research addresses how to reduce energy consumption in a community. My research presumes that effective community engagement is a central factor in achieving success and evaluates a variety of energy reduction programs based on certain criteria. The chosen criteria assess the programs’ effectiveness by focusing on different means of …

Controlling The Corrosion Of Metals With Polyphenolic Proteins

Stander Symposium Projects

Flash rusting is a corrosion process in which steel rapidly oxidizes upon contact with air at a high relative humidity. The ultimate goal of this research is to develop a water-soluble and environmentally friendly corrosion inhibitor that will inhibit flash rust on high strength steel (HY80). Several proteins involved in the formation of the adhesive byssal threads by the blue mussel Mytilus edulis L have been identified for their potential as corrosion inhibitors. The most important feature of these biomolecules for corrosion prevention applications is the presence of a post-translationally modified amino acid L-3, 4 dihydroxyphenylalanine (L-dopa). L-dopa has a …

Examining Acculturative Stressors Of The International Student: Following Study Abroad Students In South Korea And Morocco

Stander Symposium Projects

International students, particularly students studying abroad for a limited period of time, face certain challenges in entering and adjusting to a new cultural environment. This research focuses on different barriers to adjustment including language, differences in nonverbal communication, discrimination and academic pressure. By comparing and contrasting the perspectives of various students with the researcher’s experience, this research provides insight into the lived experience of international students and the researcher through on-site fieldwork and interviews conducted over a year on university campuses in South Korea and Morocco. It also discusses the results of the undertaken research and offers suggestions for resolving …

Establishing Sector Weights For The Ud Flyer Fund: A Quantitative Approach

Stander Symposium Projects

Establishing Sector Weights for the UD Flyer Fund: A Quantitative Approach Since stocks in the Flyer Fund are grouped by S&P Sectors, an important factor in the Fund’s performance is the portfolio weight given to each sector. To a large extent, sector weights depend on the Flyer Fund investment team’s evaluation of U.S. macro-economic conditions as well as monetary/fiscal policy initiatives by the U.S. Government. The decision to over or under weight a given sector, however, is based more on intuition and subjective judgment than empirical analysis. The purpose of this study, therefore, is to develop a more objective framework …

Gross Operating, Profit Momentum, And Stock Price Movement In The Cross Section Of Returns In A Short Term Analysis

Stander Symposium Projects

A number of recent academic studies have concluded that gross operating profits are a useful predictor of stock price movement, when examined in the cross section of returns. In this study we focus on momentum shifts in gross operating profits in a recent earnings period: August 31, 2011 through August 31, 2013. 30 stocks similar to the UD Flyer Fund are used for the analysis. We calculate compound annual growth rates (CAGR) in gross operating profits for 4 and 8 quarter periods . The operating profit data comes from the Bloomberg Financial Database. Using cross sectional regression analysis, we regress …

Investigating Dna Repair Processes In Bacteria: Can D. Rad Pria Load D. Rad Dnab Onto Dna Forks With A Leading Strand Gap?

Stander Symposium Projects

My research focused on the repair and replication of damaged DNA in the Deinococcus radiodurans (D. rad) bacteria, which is able to survive extreme levels of DNA damage with no detriment to its health because it is very efficient at repairing damaged DNA. In replicating (copying) bacterial DNA, damaged DNA will cause the replication to stop. This requires the DNA replication to be restarted in order for replication to be completed and cell death avoided. In most bacteria the proteins that function to restart DNA replication at points of DNA damage are fairly well conserved from bacteria to bacteria; however …