Life Sciences Commons^™

Adaptive Divergence In The Thyroid Hormone Signaling Pathway In The Stickleback Radiation, Jun Kitano, Sean C. Lema, J. Adam Luckenbach, Seiichi Mori, Yui Kawagishi, Makoto Kusakabe, Penny Swanson, Catherine L. Peichel

Biological Sciences

During adaptive radiations, animals colonize diverse environments, which requires adaptation in multiple phenotypic traits. Because hormones mediate the dynamic regulation of suites of phenotypic traits, evolutionary changes in hormonal signaling pathways might contribute to adaptation to new environments. Here we report changes in the thyroid hormone signaling pathway in stream-resident ecotypes of threespine stickleback fish (Gasterosteus aculeatus), which have repeatedly evolved from ancestral marine ecotypes. Stream-resident fish exhibit a lower plasma concentration of thyroid hormone and a lower metabolic rate, which is likely adaptive for permanent residency in small streams. The thyroid-stimulating hormone-β2 (TSHβ …

Dual Inhibition Of Sodium-Mediated Proton And Calcium Efflux Triggers Non-Apoptotic Cell Death In Malignant Gliomas, William Harley, Candace Floyd, Tamara Dunn, Xiao-Dong Zhang, Tsung-Yu Chen, Manu Hegde, Hasan Palandoken, Michael H. Nantz, Leonardo Leon, K.L. Carraway Iii, Bruce Lyeth, Fredric A. Gorin

Chemistry and Biochemistry

Malignant glioma cells maintain an elevated intracellular pH (pH_i) within hypoxic–ischemic tumormicroenvironments through persistent activation of sodium–proton transport (McLean et al., 2000). Amiloride has been reported to selectively kill human malignant glioma cell lines but not primary astrocytes (Hegde et al., 2004). While amiloride reduces pH_i of malignant gliomas by inhibiting isoform 1 of sodium–proton exchange (NHE1), direct acidification was shown to be cytostatic rather than cytotoxic. At cytotoxic concentrations, amiloride has multiple drug targets including inhibition of NHE1 and sodium–calciumexchange. Amiloride's glioma cytotoxicity can be explained, at least in part, by dual inhibition of NHE1 and …

Cinq Essais Sur Le Développement Durable, Sophie Oliver

World Languages and Cultures

My senior project is a combination of my major of Modern Languages and Literature and my minor in Sustainable Environments. I have tried to combine everything I learned in the following essays which explain different elements of the sustainable movement in the world. Currently there is a big push towards environmentalism which was started by a global desire to repair the damage done to our planet Earth. My goal is to explain some of the situations addressed by the sustainable movement and to propose some solutions based on what I’ve learned in my five years at Cal Poly. During my …

Food Processors Look To Dairy Ingredients, Phillip S. Tong

Dairy Science

No abstract provided.

Prevalence And Predictors Of Weight-Loss Maintenance In A Biracial Cohort: Results From The Coronary Artery Risk Development In Young Adults Study, Suzanne Phelan, Rena R. Wing, Catherine M. Loria, Yongin Kim, Cora E. Lewis

Kinesiology and Public Health

Background: Few population-based studies have examined the behavioral and psychosocial predictors of long-term weight-loss maintenance.
Purpose: The goal of this study was to determine the prevalence and predictors of weight-loss maintenance in a biracial cohort of younger adults.
Methods: This study examined a population-based sample of overweight/obese African-American and white men and women who had 5% weight loss between 1995 and 2000. Subsequent changes in weight, physical activity, and behavioral and psychosocial factors were examined between 2000 and 2005. Analyses were conducted in 2008 –2009.
Results: Among the 1869 overweight/obese individuals without major disease in 1995, …

A Literature Review On Crossbreeding In Dairy Cattle, Philip Owens

Dairy Science

The objective of the literature review was to determine whether or not crossbreeding is a profitable and a viable option for the dairymen of today by reviewing the literature and experiments that have been conducted throughout the world by today’s dairy professionals and leaders. The Dairy market today is increasingly competitive and more and more dairymen are considering crossbreeding to decrease health costs and increase profitability. Price premiums from cheese plants are given to milk producers for high components like protein and fat. In recent studies done by universities and research facilities around the world, results have found promising numbers …

Burning Manure As An Economical Energy Source, Ron Machado

Dairy Science

The dairy industry is under pressure from increasing environmental regulations, falling prices, as well as very aggressive foreign competition. Manure management and electrical costs are one area dairymen can look to cut costs. My objective for this project was to determine how cost effective biomass gasification of manure is at generating electricity. The proposed project was designed for a manure production equal to a 3,000 cow herd. I used standard capital budgeting techniques to determine the efficiency of the project, primarily focusing on the net present value, internal rate of return, and payback period.

Institution Of Presynch Protocol, Justin Breedyk

Dairy Science

The objective of this study was to compare factors of reproductive efficiency between two separate ovulation synchronization programs, with one that includes presynchronization of all fresh cows and one that does not ovsynch cows until they have been found open after initial insemination. In recent years, reproductive efficiency has declined as other areas of the dairy business have continued to excel. The investigation was performed on two dairies in Hart, Texas, White River Ranch and VB Dairy. The dairies include herds of 5,000 and 3,000 milking cows, respectively. Data was retrieved using Dairy Comp 305 and covered a two month …

A Comparison Between The Dhia Test For Somatic Cell Counts Compared To Porta Side Test On The Individual Quarters Of The High Scc Cows At The Cal Poly Dairy, Melissa Zimmer

Dairy Science

The objective of my senior project is to determine if California Mastitis Test (CMT) and the Porta Side Somatic Cell Count (SCC) Test is equivalent to the DHIA laboratory somatic cell test. The data was taken from the Cal Poly Dairy on October 19th, 2010. Samples were taken from eight Holstein cows during milking time and the tests were run in the barn. These eight cows were the highest somatic cell count cows at the Cal Poly Dairy on the previous test day October 9, 2010. During milking the cows were pre and post dipped before the samples were taken. …

Effectiveness Of A Presynchronization Program Implemented On A Modern Dairy Facility, R. (Robert) E. Thommen

Dairy Science

The objective of this study was to determine the success of a presynchronization program implemented on a modern dairy facility. The study was conducted on a 1,400 cow dairy in the central valley of California. 86 cows were involved in the study during the summer months of June through September. Cows were either assigned in the synchronization program or placed in a control group based on the last digit of their identification. At 43 DIM, presync cows were injected with their first treatment of the synchronization program. Estrous cycles of the presync group were manipulated with treatments of Prostaglandin and …

Cal Poly Embryo Recovery Record System, Kelsey Donahoo-Cheda

Dairy Science

No abstract provided.

Use Of Endovac-Bovi In Pre-Weaned Calves, Jena Glasgow

Dairy Science

No abstract provided.

Genotype And Breed Trend Influences On Citric Acid And Coagulation Times Of Raw Milk, Melissa Looney

Dairy Science

The objective of the study was to determine if citric acid levels measured in milk was related to genetic variants identified in Holstein and Jersey cows. The data used were milk samples collected from both Holstein and Jersey cows at Cal Poly, San Luis Obispo. Citric acid levels and other constituents were measured using FTIR methods with the FOSS MilkoscanTM FT2 on each sample. Genotypes were obtained for the DGAT 1 locus using polymerase chain reaction and an enzymatic digestion using the MWO I restriction enzyme. Observations were obtained on 13 Holsteins and 12 Jersey cows. Results indicated that citric …

Ultraviolet Light As An Adjunct Treatment To Pasteurization For Microbial Reduction In Milk Intended For Extended Shelf Life, Jacob Zonneveld

Dairy Science

The objective of this study was to determine whether ultraviolet light treatment of milk could be used in adjunct with pasteurization and to determine whether the microbial count in bulk tank raw milk was sufficient enough to receive significant results. Samples were collected from a bulk tank filled with 1600 gallons of raw Holstein and Jersey milk from the Cal Poly Dairy throughout the course of a week. Control (library) samples were also taken from the raw milk tank and stored without air or agitation for comparison. These samples were plated each day and examined 24 and 48 hours after …

Cystic Ovaries In Dairy Cattle, Lacey Morgan Rosenberg

Dairy Science

The objective of this literature review was to determine the potential causes and factors affecting the incidence of ovarian cysts in dairy cattle as well as to examine functionality of various preventative methods and treatments of cysts. The end product was to be a document outlining all the information available on the three different types of cysts that can develop on the bovine ovary, follicular cysts, luteal cysts, and cystic corpora lutea. The literature that was reviewed, most in the forms of research papers, articles, and reviews, came primarily from scientific journals and published books. The literature reviewed was only …

Use Of An Activity Monitoring System As Part Of The Cal Poly Dairy Breeding Protocol, Trevor Nutcher

Dairy Science

The objective of this study, is to determine the effectiveness of an activity monitoring system as an integral part of the Cal Poly Dairy breeding protocol. Dairy herd reproductive efficiencies have dropped in the past 40 years. Increased milk production, and genetic advancements towards more milk production, have led to reproductive rates declining. An advanced breeding program is needed to become more efficient in this area. The study consisted of the evaluation of one option, Heatime™ by MICRO Dairy Logic, and comparing it to the commonly used programs in dairies today such as synchronization methods, pedometers, and other electronic detection …

Controlling The Mineral Content Of Sweet Whey Powder In An Industrial Setting, Matthew W. Sawyer

Dairy Science

The objective of this project was to reduce the final ash content of sweet whey powder. The data for this project was collected over a two-week period, from July 13th to July 27th 2010 in a dairy plant in the Mid-West of the United States. The data is composed of particle size test, ash test, and pH test. The conclusions of this study are that multiple pre-heat treatment tank changes contribute to mineral content by requiring more buffering than usual. The low pH of this pre-heat liquid forces a need for more buffering. Particle segregation may play a role in …

Methane Digesters, Thomas Van Steyn

Dairy Science

Anaerobic digestion has many different avenues for opportunity in use on farms. The objective of my senior project is to determine the economic viability of alternative methane digesters on a dairy. Currently the conversion of animal manure to biogas through the process of anaerobic digestion is widely used in Europe. In the U.S. anaerobic digesters have become increasingly in demand by environmental groups and dairymen. Digesters environmental impact involves the benefit by capturing the biogas that comes off animal manure. Methane, a green house gas, is the one with the most concern that is captured by methane digesters. The biogas …

Regalia-Induced Resistance In Powdery Mildew-Infected Grapevine Plants Correlates With The Induction Of Chalcone Synthase, Thomas Crottogini

Horticulture and Crop Science

No abstract provided.

Rangeland Condition Assessment Of A Portion Of The Cal Poly Sheep Unit, Colin S. Mckim

Animal Science

This rangeland condition assessment was conducted as part of the Cal Poly Rangeland Condition Assessment Project. Five pastures comprising 31.7 acres at the Cal Poly sheep unit were assessed to collect baseline ecological information. Methods used were Line-point Intercept, Belt Transect, Residual Dry Matter, and the rangeland health indicators recommended by Pyke et al., 2002. Additionally, a preliminary species list was collected. The rangeland health assessment method found all pastures to have no to slight departure from the local reference area when evaluated for soil and site stability, hydrologic function, and biotic integrity.

Investigating Wood Welding Parameters Using A Prototype Welding Machine, Timothy R. Melin

Master's Theses

Understanding how different processing variables influence wood welded bonds is vital if the technique will ever be used to create engineered lumber without using adhesives. A variation of vibration welding, wood welding uses pressure and friction to bond materials together. During welding, heat causes a softening in the wood, a naturally occurring composite material. This softening leads to fiber entanglement and a bond forms upon cooling.

The goal of this research was to investigate several processing aspects of the wood welding procedure. A prototype wood welding machine, designed and fabricated from the ground up, was used to investigate the effects …

Effect Of Sodium Chloride Addition During Diafiltration On The Solubility Of Milk Protein Concentrate, Scott J. Gualco

Master's Theses

There is considerable interest among food manufacturers to incorporate protein into food products in both developed and developing countries. Dairy proteins are excellent choices for many different applications, as they are known to have several nutritional and functional benefits. Membrane filtration techniques are often utilized as the preferred method of fractionation, due to the high throughput and continuous nature of the process. One such product produced from membrane filtration of skim milk is called milk protein concentrate. This product is valued for its high protein content, but it has historically exhibited poor solubility when reconstituted into water, which severely restricts …

Flowering Locus C Influences The Timing Of Shoot Maturation In Arabidopsis Thaliana, Laurie Mentzer, Tarah Yee, Tina Y. Wang, Edward Himelblau

Biological Sciences

No abstract provided.

Universal Play Frame Vi, Justin Bazant, Cullen Crackel, Anthony Franceschi

Mechanical Engineering

This design report details the design process utilized by Adaptive Exercise Designs (AED) in creating the sixth design of the Universal Play Frame (UPF). The UPF is an adaptive frame which supports a variety of devices that allows athletes in wheelchairs with limited range of motion to participate in physical activity. The past five frame designs do not meet the needs of the Friday Club due to complications with function and time constraints. To ensure all of Fridays Club's needs were met, the problem was better defined by converting the customer requirements into engineering specifications. The design process our team …

Development And Validation Of A Light Weight, Energy Dense, Ready To Eat (Rte) Bar, Jacob Wilhelm-Maria Heick

Master's Theses

DEVELOPMENT AND VALIDATION OF A LIGHT WEIGHT, ENERGY DENSE, READY TO EAT (RTE) BAR

Jacob Wilhelm-Maria Heick

Providing additional calories in the form of an RTE bar to endurance athletes will increase performance and muscle re-synthesis, reduce muscle breakdown, and shorten recovery time. An RTE bar containing a blend of dairy proteins and carbohydrates will create a product with superior functionality, including bioactive and immunity enhancing properties from dairy derived ingredients. The protein will provide benefits in the form of easily digestible calories, essential amino acids and physical satiate.

A formulation was developed and optimized, resulting in a final product …

The Influence Of Persistent Pathogens On Circulating Levels Of Inflammatory Markers: A Cross-Sectional Analysis From The Multi-Ethnic Study Of Atherosclerosis, Aydin Nazmi, Ana V. Diez-Roux, Nancy S. Jenny, Michael Y. Tsai, Moyses Szklo, Allison E. Aiello

Food Science and Nutrition

Background: Systemic inflammation is linked to cardiovascular risk, but the influence of persistent pathogens, which are conventionally dichotomously categorized, on circulating levels of inflammatory markers is not clear. Antibody levels of pathogens have not been examined in relation to inflammation.
Methods: Using data from a subsample of the Multi-Ethnic Study of Atherosclerosis, we examined circulating levels of interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen in relation to five common persistent pathogens: cytomegalovirus, herpes simplex virus-1, Hepatitis A virus, Helicobacter pylori and Chlamydia pneumoniae. We tested the hypothesis that the number of seropositive pathogens (based on conventional …

Cross-Sectional And Longitudinal Associations Of Neighborhood Characteristics With Inflammatory Markers: Findings From The Multi-Ethnic Study Of Atherosclerosis, Aydin Nazmi, Ana Diez Roux, Nalini Ranjit, Teresa E. Seeman, Nancy S. Jenny

Food Science and Nutrition

We investigated cross-sectional associations of neighborhood deprivation, problems, safety, and cohesion with circulating levels of fibrinogen, interleukin-6, and C-reactive protein (n=5370) and longitudinal associations with changes in IL-6 over a 3–4 year period (n=946). In cross-sectional analyses, higher levels of neighborhood deprivation and problems were associated with higher levels of all three inflammatory markers, whereas higher levels of safety were associated with lower levels. Fibrinogen remained associated with all neighborhood characteristics except cohesion and IL-6 remained associated with safety after adjustment for race and SES. In longitudinal analyses, higher levels of neighborhood deprivation and problems, and lower levels of safety …

Designing Marine Reserve Networks For Both Conservation And Fisheries Management, Steven D. Gaines, Crow White, Mark H. Carr, Stephen R. Palumbi

Biological Sciences

Marine protected areas (MPAs) that exclude fishing have been shown repeatedly to enhance the abundance, size, and diversity of species. These benefits, however, mean little to most marine species, because individual protected areas typically are small. To meet the larger-scale conservation challenges facing ocean ecosystems, several nations are expanding the benefits of individual protected areas by building networks of protected areas. Doing so successfully requires a detailed understanding of the ecological and physical characteristics of ocean ecosystems and the responses of humans to spatial closures. There has been enormous scientific interest in these topics, and frameworks for the design of …

Evaluation Of School Wellness Policies In North San Luis Obispo County (Final Report), Ann Yelmokas Mcdermott, David W. Hey, Laurie Pugh, Rosanna Taylor, Arlene Grant-Holcomb, Stephanie F. Teaford

Kinesiology and Public Health

A two year grant (October 2008-2010) was awarded to the San Luis Obispo County Public Health Department (SLO-PHD) so that outside agencies could engage in school wellness policy (SWP) advocacy and community activities to aid in combating the growing epidemic of obesity among the county‘s high risk populations. Under SLO-PHD oversight, Healthy Eating Active Living (HEAL-SLO) proposed school district outcomes, objectives, and indicators. (Attachment A provides the SWP rationale while Attachment B contains the HEAL-SLO/TCE purpose and goals.) In March 2009, a research team from newly formed STRIDE at California Polytechnic State University was contracted to review and evaluate Lillian …

Traversing Swanton Road, 2nd Ed., James A. West

Academic, Government & Associated Organizational Research Resources

Situated at the northwest end of Santa Cruz County and occupying circa 30 square miles of sharply contrasted terrain, the Scott Creek Watershed concentrates within its geomorphological boundaries, at least 10-12% of California's flora, both native and introduced. Paradoxically, the use/abuse that the watershed has sustained over the past 140+ years, has not necessarily diminished the biodiversity and perhaps parallels the naturally disruptive but biologically energizing processes (fire, flooding, landslides and erosion), which have also been historically documented for the area for +60 years. This is an early edition of an extensive document by James A. West. Please visit the …