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Normal Development Of The Aortic Isthmus, Elizabeth Short

Yale Medicine Thesis Digital Library

The development of the aortic isthmus, that region of the arch of the aorta between the left subclavian artery and the attachment of the ligamentum arteriosum, has received little attention. While the developmental history of the ductus arteriosus and foramen ovale has been well documented, as have the cardiac malformations associated with failure to complete this developmental sequence, little work has been done to define the normal sequence of isthmus development in its transition to an adult configuration in the postnatal period. It has long been recognized that the cardiac malformation known as infantile or preductal coarctation of the aorta …