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Articles 1 - 30 of 92
Full-Text Articles in Life Sciences
The Rhesus Monkey Brain : In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Michael Petrides, Arthur Toga
The Rhesus Monkey Brain : In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Michael Petrides, Arthur Toga
Xu-Feng Huang
Description The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive and accurate atlas of the monkey brain currently available. The second edition of this classic book is a complete revision, featuring many improvements and upgrades. Constructed by the established leaders in neuroanatomical atlas development, the new edition will again be the indispensable resource for all scientists working on the primate nervous system. Key Features * 151 coronal diagrams and 151 accompanying photographic plates spaced at 120 um intervals; diagrams completely revised * 60 photographic coronal plates of SMI immunoreactivity; delineations completely revised. New in this edition * DVD …
The Dopamine B-Hydroxylase 19 Bp Insertion/Deletion Polymorphism Was Associated With First-Episode But Not Medicated Chronic Schizophrenia, Li Hui, Xuan Zhang, Xu-Feng Huang, Mei Han, Francesca Fernandez, Yaqin Yu, Shilong Sun, Wenjun Li, Da Chen, Mei Xiu, Thomas Kosten, Xiang Zhang
The Dopamine B-Hydroxylase 19 Bp Insertion/Deletion Polymorphism Was Associated With First-Episode But Not Medicated Chronic Schizophrenia, Li Hui, Xuan Zhang, Xu-Feng Huang, Mei Han, Francesca Fernandez, Yaqin Yu, Shilong Sun, Wenjun Li, Da Chen, Mei Xiu, Thomas Kosten, Xiang Zhang
Xu-Feng Huang
Background: Numerous studies report dysfunctional dopaminergic and noradrenergic neurotransmission in the pathogenesis of schizophrenia. Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline. Functional polymorphisms have been reported in the promoter region of DBH gene, including a 19 bp insertion/deletion polymorphism. The purpose of this study was to investigate whether there was an association between the functional polymorphism (DBH50-Ins/Del) and schizophrenia in a Han Chinese population. Methods: This polymorphism was genotyped in 221 first-episode schizophrenics, 360 chronic schizophrenics and 318 healthy controls using a case-control design. We assessed their psychopathology using the Positive and Negative …
Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang
Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
The Rhesus Monkey Brain In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Arthur Toga
The Rhesus Monkey Brain In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Arthur Toga
Xu-Feng Huang
From the Back Cover The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive, detailed atlas of the monkey brain ever constructed. The first chapter, "Photographic and Diagrammatic Atlas of the Rhesus Monkey Brain," presents 151 plates illustrating the subcortex and parts of the cortex in high magnification, and 151 corresponding diagrams complementing each image. The second chapter, "Delineation of the Rhesus Monkey Cortex on the Basis of the Distribution of a Neurofilament Protein," consists of 64 fully labeled plates depicting an entire hemisphere. Jointly, the two chapters constitute the most serious morphological work ever undertaken on the monkey. …
Influence Of Dietary Fats On C-Fos-Like Immunoreactivity In Mouse Hypothalamus, Hong-Qin Wang, Leonard Storlien, Xu-Feng Huang
Influence Of Dietary Fats On C-Fos-Like Immunoreactivity In Mouse Hypothalamus, Hong-Qin Wang, Leonard Storlien, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Alterations In 5-Ht2a Receptor Binding In Various Brain Regions Among 6-Hydroxydopamine-Induced Parkinsonian Rats, Yun Li, Xu-Feng Huang, Chao Deng, Barbara Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori Yenari, Qing Wang
Alterations In 5-Ht2a Receptor Binding In Various Brain Regions Among 6-Hydroxydopamine-Induced Parkinsonian Rats, Yun Li, Xu-Feng Huang, Chao Deng, Barbara Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori Yenari, Qing Wang
Xu-Feng Huang
The serotonergic system has close interactions with the dopaminergic system and is strongly implicated in the pathophysiological mechanisms and therapeutic paradigms of Parkinson’s disease (PD). This study aims to investigate regional changes in 5-hydroxytryptamine (5-HT) 2A receptors in the rat brain 3 weeks after unilateral medial forebrain bundle lesion by 6-hydroxydopamine (6-OHDA). 5-HT 2A receptor distributions and alterations in the postmortem rat brain were detected by [3H]ketanserin-binding autoradiography. In the 6-OHDA-induced Parkinson’s rat model, nigrostriatal dopaminergic neuron loss significantly mediated the decreased [3H]ketanserin binding, predominantly in the agranular insular cortex (17.3%, P 5 0.03), cingulate cortex (18.2%, P < 0.001), prefrontal …
The Role Of Histaminergic H1 And H3 Receptors In Food Intake: A Mechanism For Atypical Antipsychotic-Induced Weight Gain?, Chao Deng, Katrina Western-Green, Xu-Feng Huang
The Role Of Histaminergic H1 And H3 Receptors In Food Intake: A Mechanism For Atypical Antipsychotic-Induced Weight Gain?, Chao Deng, Katrina Western-Green, Xu-Feng Huang
Xu-Feng Huang
Atypical antipsychotics such as olanzapine and clozapine are effective at treating the multiple domains of schizophrenia, with a lowrisk of extra-pyramidal side-effects. However amajor downfall to their use is metabolicside-effects particularly weight gain/obesity,which occurs by unknownmechanisms. The present paper explores the potential candidature of histaminergic neurotransmission in the mechanisms of atypical antipsychoticinduced weight gain, with a focus on the histaminergic H1 and H3 receptors. Olanzapine and clozapine have a high affinity for the H1 receptor, andmeta-analyses showa strong correlation between risk ofweight gain andH1 receptor affinity. In addition, olanzapine treatment decreases H1 receptor binding and mRNA expression in the rat …
Effects Of Simvastatin And 6-Hydroxydopamine On Histaminergic H1 Receptor Binding Density In Rat Brains, Chang-Hua Hu, Chao Deng, Nikolce Mackovski, Ling Long, Cansheng Zhu, Yu Yang, Yuge Wang, J-Z Chen, Xu-Feng Huang, Qing Wang
Effects Of Simvastatin And 6-Hydroxydopamine On Histaminergic H1 Receptor Binding Density In Rat Brains, Chang-Hua Hu, Chao Deng, Nikolce Mackovski, Ling Long, Cansheng Zhu, Yu Yang, Yuge Wang, J-Z Chen, Xu-Feng Huang, Qing Wang
Xu-Feng Huang
Statins have been widely used for the treatment of a variety of medical conditions including psychoneurological disorders beyond their original use in lowering cholesterol. Histamine receptors play an important role in the regulation of neural activity, however, it is unknown whether statins act on histamine receptors, particularly for their neural regulatory effects. This study examined the effects of simvastatin and 6-hydroxydopamine (6-OHDA) lesions on histamine H1 receptors using [3H] pyrilamine binding autoradiography. Compared to the saline group, simvastatin (1 mg/kg/day) significantly decreased H1 receptor bindings in the primary motor cortex (M1), ventromedial hypothalamic nucleus (VMH), caudate putamen (CPu), accumbens core …
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Xu-Feng Huang
Antipsychotic drugs have various neuropharmacological properties as a result of their structural diversity. Despite their therapeutic benefits, most of the prescribed atypical antipsychotics can induce severe side effects, including weight gain, type II diabetes mellitus, and cardiovascular diseases. Among the developed atypical antipsychotic agents, tetracyclic dibenzodiazepine and thienobenzodiazepine compounds, particularly clozapine and olanzapine, are associated with the greatest weight gain and metabolic disturbances. However, the unique chemical structure of these compounds causes the low risk of side effects reported for typical antipsychotics (e.g. extrapyramidal symptoms and tardive dyskinesia). This report reviews the recent discovery of the potential role of the …
Neurodevelopment, Neurotransmitter Imbalance And Cognitive Dysfunction In Schizophrenia, Teresa Du Bois, Xu-Feng Huang
Neurodevelopment, Neurotransmitter Imbalance And Cognitive Dysfunction In Schizophrenia, Teresa Du Bois, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Developmental Vitamin D Deficiency Alters Mk-801-Induced Behaviours In Adult Offspring, James Kesby, Jonathan O'Loan, Suzanne Alexander, Chao Deng, Xu-Feng Huang, John Mcgrath, Darryl Eyles, Thomas Burne
Developmental Vitamin D Deficiency Alters Mk-801-Induced Behaviours In Adult Offspring, James Kesby, Jonathan O'Loan, Suzanne Alexander, Chao Deng, Xu-Feng Huang, John Mcgrath, Darryl Eyles, Thomas Burne
Xu-Feng Huang
Rationale Developmental vitamin D (DVD) deficiency is a candidate risk factor for developing schizophrenia in humans. In rodents DVD deficiency induces subtle changes in the way the brain develops. This early developmental insult leads to select behavioural changes in the adult, such as an enhanced response to amphetamine-induced locomotion in female DVD-deficient rats but not in male DVDdeficient rats and an enhanced locomotor response to the Nmethyl- D-aspartate (NMDA) receptor antagonist, MK-801, in male DVD-deficient rats. However, the response to MK- 801-induced locomotion in female DVD-deficient rats is unknown. Therefore, the aim of the current study was to further examine …
Reciprocal Signalling Between Nr2 Subunits Of The Nmda Receptor And Neuregulin 1 And Their Role In Schizophrenia, Amy Geddes, Xu-Feng Huang, Kelly A. Newell
Reciprocal Signalling Between Nr2 Subunits Of The Nmda Receptor And Neuregulin 1 And Their Role In Schizophrenia, Amy Geddes, Xu-Feng Huang, Kelly A. Newell
Xu-Feng Huang
Schizophrenia is a debilitating neurodevelopmental psychiatric disorder. Both the N-methyl-D-aspartate receptor (NMDAR) and neuregulin1 (NRG1) are key molecules involved in normal brain development that have been linked to schizophrenia pathology and aetiology. The NR2 proteins are critical structural and functional subunits of the NMDAR and are developmentally and spatially regulated. Altered NR2 gene and protein expression has been found in human post-mortem schizophrenia brain tissue together with changes in NRG1 and its receptor ErbB4. The NR2 subunits and ErbB4 share a common anchoring domain on the postsynaptic density and therefore a disruption to either of these molecules may influence the …
The Effects Of Antipsychotic Drugs Administration On 5-Ht1a Receptor Expression In The Limbic System Of The Rat Brain, Mei Han, Xu-Feng Huang, Teresa Du Bois, Chao Deng
The Effects Of Antipsychotic Drugs Administration On 5-Ht1a Receptor Expression In The Limbic System Of The Rat Brain, Mei Han, Xu-Feng Huang, Teresa Du Bois, Chao Deng
Xu-Feng Huang
Increasing evidence suggests that 5-HT1A receptors are involved in the pathophysiology and treatment of schizophrenia. This paper investigated 5-HT1A receptor mRNA expression and binding density in female rats treated with aripiprazole (2.25 mg/kg/day), olanzapine (1.5 mg/kg/day), haloperidol (0.3 mg/kg/day) or vehicle (control) orally three times/day for 1 or 12 weeks. Animals were sacrificed 48 h after the last administration. Aripiprazole significantly increased 5-HT1A receptor binding density by 33% in the CA1 region of the hippocampus and by 21% in the medial posterodorsal nuclei of posterior amygdala (MeP) compared to the control group after 1 week of treatment. Olanzapine significantly decreased …
Insulin Decreases Therapeutic Efficacy In Colon Cancer Cell Line Ht29 Via The Activation Of The Pi3k/Akt Pathway, J-Z Chen, Andrew Katsifis, Changhua Hu, Xu-Feng Huang
Insulin Decreases Therapeutic Efficacy In Colon Cancer Cell Line Ht29 Via The Activation Of The Pi3k/Akt Pathway, J-Z Chen, Andrew Katsifis, Changhua Hu, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Acute Sleep Restriction Alters Neuroendocrine Hormones And Appetite In Healthy Male Adults, Christopher Magee, Xu-Feng Huang, Don Iverson, Peter Caputi
Acute Sleep Restriction Alters Neuroendocrine Hormones And Appetite In Healthy Male Adults, Christopher Magee, Xu-Feng Huang, Don Iverson, Peter Caputi
Xu-Feng Huang
No abstract provided.
Density Of Metabotropic Glutamate Receptors 2 And 3 (Mglur2/3) In The Dorsolateral Prefrontal Cortex Does Not Differ With Schizophrenia Diagnosis But Decreases With Age, Elisabeth Frank, Kelly Newell, Xu-Feng Huang
Density Of Metabotropic Glutamate Receptors 2 And 3 (Mglur2/3) In The Dorsolateral Prefrontal Cortex Does Not Differ With Schizophrenia Diagnosis But Decreases With Age, Elisabeth Frank, Kelly Newell, Xu-Feng Huang
Xu-Feng Huang
Metabotropic glutamate receptors 2 and 3 (mGluR2/3) have been shown as efficient targets for antipsychotic intervention. We therefore investigated the receptor density of mGluR2/3 in the dorsolateral prefrontal cortex (dlPFC; Brodman area 46) of schizophrenia/schizoaffective patients (n=37) and matched controls (n=37) using receptor autoradiography. No difference in mGluR2/3 density was identified in relation to schizophrenia diagnosis. Overall and in individual groups, a negative correlation of mGluR2/3 density and age at death has been found. These and previous results suggest that density of mGluR2/3 in the dlPFC is less likely to impact on the efficiency of the mGluR2/3 agonist in treating …
Antipsychotic Treatment And Neuregulin 1 -Erbb4 Signalling In Schizophrenia, Bo Pan, Xu-Feng Huang, Chao Deng
Antipsychotic Treatment And Neuregulin 1 -Erbb4 Signalling In Schizophrenia, Bo Pan, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
Evidence from genetic, transgenic and post-mortem studies has strongly supported the critical role that neuregulin 1 (NRG1) and its ErbB4 receptor plays in the pathophysiology of schizophrenia. This article aims to review current evidence regarding the effects of antipsychotic treatment on NRG1–ErbB4 signalling. NRG1 and ErbB4 knockout mice display abnormal behaviours relevant to certain features of schizophrenia, which could be improved by antipsychotic (clozapine/haloperidol) treatment. In contrast to most NRG1/ErbB4 knockout mice with a decreased NRG1–ErbB4 signalling, the majority post-mortem studies showed an increased NRG1–ErbB4 signalling in schizophrenic patients. These differences could be due to degrees of alteration in risk …
Organization Of Brainstem Nuclei, George Paxinos, Xu-Feng Huang, Gulgun Sengul, Charles Watson
Organization Of Brainstem Nuclei, George Paxinos, Xu-Feng Huang, Gulgun Sengul, Charles Watson
Xu-Feng Huang
This chapter describes human homologs of nuclei identified in the brainstem of other mammals and attempts to extend to the human the overall organizational schemata that have been proposed for the brainstem of other mammalian species. We present herein updated diagrams of the Atlas of the Human Brainstem (Paxinos and Huang, 1995). The diagrams have been thoroughly revised in light of our recent work on the rat (Paxinos and Watson, 2007) and rhesus monkey (Paxinos et al., 3rd ed, in BrainNavigator, Elsevier, 2010) as well as our work on the marmoset (Atlas of the Marmoset Brain in Stereotaxic Coordinates, Paxinos …
Obesity, The P13k/Akt Signal Pathway And Colon Cancer, Xu-Feng Huang, J-Z Chen
Obesity, The P13k/Akt Signal Pathway And Colon Cancer, Xu-Feng Huang, J-Z Chen
Xu-Feng Huang
No abstract provided.
Metabolic Parameters And Emotionality Are Little Affected In G-Protein Coupled Receptor 12 (Gpr12) Mutant Mice, Elisabeth Frank, Yizhen Wu, Naomi Piyaratna, William James Body, P Snikeris, Timothy South, Anna-Karin Gerdin, Mikael Bjursell, Mohammad Bohlooly-Y, Leonard H. Storlien, Xu-Feng Huang
Metabolic Parameters And Emotionality Are Little Affected In G-Protein Coupled Receptor 12 (Gpr12) Mutant Mice, Elisabeth Frank, Yizhen Wu, Naomi Piyaratna, William James Body, P Snikeris, Timothy South, Anna-Karin Gerdin, Mikael Bjursell, Mohammad Bohlooly-Y, Leonard H. Storlien, Xu-Feng Huang
Xu-Feng Huang
Background: G-protein coupled receptors (GPR) bear the potential to serve as yet unidentified drug targets for psychiatric and metabolic disorders. GPR12 is of major interest given its putative role in metabolic function and its unique brain distribution, which suggests a role in emotionality and affect. We tested Gpr12 deficient mice in a series of metabolic and behavioural tests and subjected them to a well-established high-fat diet feeding protocol. Methodology/Principal Findings: Comparing the mutant mice with wild type littermates, no significant differences were seen in body weight, fatness or weight gain induced by a high-fat diet. The Gpr12 mutant mice displayed …
Histamine H1 Receptor Agonist And Control Of Olanzapine-Induced Obesity, Jiamei Lian, Xu-Feng Huang, N Pai, C Deng
Histamine H1 Receptor Agonist And Control Of Olanzapine-Induced Obesity, Jiamei Lian, Xu-Feng Huang, N Pai, C Deng
Xu-Feng Huang
No abstract provided.
Effects Of Simvastatin And 6-Hydroxydopamine Lesion On Histaminergic H1 Receptor Binding In Rat Brains, C H. Hu, C Deng, Xu-Feng Huang, J Chen, Q Wang
Effects Of Simvastatin And 6-Hydroxydopamine Lesion On Histaminergic H1 Receptor Binding In Rat Brains, C H. Hu, C Deng, Xu-Feng Huang, J Chen, Q Wang
Xu-Feng Huang
No abstract provided.
The Effects Of Antipsychotics On The Density Of Cannabinoid Receptors In The Dorsal Vagal Complex Of Rats: Implications For Olanzapine-Induced Weight Gain, Katrina Weston-Green, Xu-Feng Huang, Mei Han, Chao Deng
The Effects Of Antipsychotics On The Density Of Cannabinoid Receptors In The Dorsal Vagal Complex Of Rats: Implications For Olanzapine-Induced Weight Gain, Katrina Weston-Green, Xu-Feng Huang, Mei Han, Chao Deng
Xu-Feng Huang
Some atypical antipsychotics clinically used to treat schizophrenia induce weight gain by unknown mechanisms. The dorsal vagal complex (DVC) of the brainstem and the endogenous cannabinoid system are implicated in the regulation of appetite signalling and food intake. We investigated whether antipsychotic drugs alter cannabinoid receptor-binding density in the DVC. Female Sprague–Dawley rats were treated with olanzapine, haloperidol, aripiprazole or vehicle for 1 wk (short-term) or 12 wk (chronic). Quantitative autoradiographic methods were employed to investigate the binding density of cannabinoid receptors in the DVC using a highly sensitive Beta Imager. Short-term olanzapine induced a significant 39% decrease in cannabinoid …
Neuropeptide Y Mrna Expression Levels Following Chronic Olanzapine, Clozapine And Haloperidol Administration In Rats, Xu-Feng Huang, Katerina Zavitsanou, Chao Deng
Neuropeptide Y Mrna Expression Levels Following Chronic Olanzapine, Clozapine And Haloperidol Administration In Rats, Xu-Feng Huang, Katerina Zavitsanou, Chao Deng
Xu-Feng Huang
No abstract provided.
Inter-Meal Interval Is Increased In Mice Fed A High Whey, As Opposed To Soy And Gluten, Protein Diets, Xu-Feng Huang, Timothy South, Yinghua Yu
Inter-Meal Interval Is Increased In Mice Fed A High Whey, As Opposed To Soy And Gluten, Protein Diets, Xu-Feng Huang, Timothy South, Yinghua Yu
Xu-Feng Huang
This study aimed to characterise meal patterns and satiety effects of diets that are high in protein but differ in protein source. Using a computerised automatic recording system, meal pattern behaviour was recorded continuously for 7 days in mice fed single (whey, soy or gluten) or different combined protein diets. Overall, average energy intake was significantly lower in mice fed a whey protein diet than those fed soy, gluten and lab chow diets. Among these four diets, the inter-meal interval of mice fed a whey protein diet was the longest and their meal number was the lowest. Combination of whey …
Decreased Density Of Serotonin 2a Receptors In The Superior Temporal Gyrus In Schizophrenia - A Postmortem Study, Xu-Feng Huang, Chao Deng, Qing Wang, Kai Kang
Decreased Density Of Serotonin 2a Receptors In The Superior Temporal Gyrus In Schizophrenia - A Postmortem Study, Xu-Feng Huang, Chao Deng, Qing Wang, Kai Kang
Xu-Feng Huang
The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia,particularly with regards to auditory hallucinations. In this study, using in situ quantitative autoradiography in postmortem tissue, we investigated the binding of the [3H]ketanserin to 5-HT2A receptors and [3H] mesulergine to 5-HT2C receptors in the left STG of 8 male schizophrenic patients compared to 8 control subjects. A strong [3H]ketanserin binding was observed in the STG, however there was a very weak [3H] mesulergine binding in the STG. A significant decrease in binding of [3H]ketanserin was clearly observed in schizophrenia patients in comparison with control subjects. There were …
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
Xu-Feng Huang
Cannabis increases the risk of schizophrenia in genetically vulnerable individuals. In this study we aim to show that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the development of tolerance to cannabinoids in mice. Nrg1 heterozygous (HET) and wild-type (WT) mice were treated daily for 15 d with the synthetic analogue of D9-tetrahydrocannabinol, CP55,940 (0.4 mg/kg). We measured the impact of this exposure on locomotor activity, anxiety, prepulse inhibition (PPI), body temperature and FosB/DFosB immunohistochemistry. Tolerance to CP55,940-induced hypothermia and locomotor suppression developed more rapidly in Nrg1 HET mice than WT mice. Conversely in the light-dark test, while tolerance to …
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Xu-Feng Huang
The present study investigated body weight gain, food intake, open-field activity and brain histamine H1 receptor mRNA and protein expression in rats treated with three types of antipsychotics. Rats were divided into eight groups and treated with aripiprazole (2.25mg/kg/day), olanzapine (1.5mg/kg/day), haloperidol (0.3mg/kg/day) or vehicle (as control) for 1 or 12 weeks. Administration of olanzapine for 1 week led to a threefold increase in body weight gain and a 35% increase in fat deposits compared to controls (p<0.05). In the 12-week olanzapine treatment group, accumulative food intake was significantly higher in the first 7 weeks of treatment compared to …
Ventromedial Hypothalamic Npy Y2 Receptor In The Maintenance Of Body Weight In Diet-Induced Obesity In Mice, Yulin Li, Xu-Feng Huang, Chao Deng, Qing Wang, Timothy South, Yinghua Yu
Ventromedial Hypothalamic Npy Y2 Receptor In The Maintenance Of Body Weight In Diet-Induced Obesity In Mice, Yulin Li, Xu-Feng Huang, Chao Deng, Qing Wang, Timothy South, Yinghua Yu
Xu-Feng Huang
This study examined changes in neuropeptide Y (NPY) Y2 receptor binding in the brains of C57BL/6 mice in response to different levels of high-fat diets via three dietary intervention methods: high-fat diet, switching from high- to low-fat diet and finally, energy restricted high-fat diet. Forty-five C57Bl/6 male mice were fed a high-fat diet for 8 weeks and then classified as diet-induced obese (DIO) or diet-resistant (DR) mice according to the highest and lowest body weight gainers, respectively. The DIO and DR mice were then randomly divided into three groups each and either continued on their high-fat diet ad libitum (DIO-H …
Increased Cannabinoid Receptor Density In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Chao Deng
Increased Cannabinoid Receptor Density In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
No abstract provided.