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Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
Mapping Regions Of Rnf168 Required For Its Degradation By Icp0, Andrea Cyr, Matthew Weitzman
Mapping Regions Of Rnf168 Required For Its Degradation By Icp0, Andrea Cyr, Matthew Weitzman
e-Research: A Journal of Undergraduate Work
Viruses establish infection by overtaking host cell processes and developing mechanisms that promote viral replication. Herpes simplex virus undergoes lytic and latent cycles of infection throughout the lifespan of its host. The viral genome is transcriptionally silent during latency, but viral proteins are produced upon reactivation. Herpes simplex virus type 1 encodes the ICP0 protein, an E3 ubiquitin ligase required for reactivation from latency of the infectious virus. The immediate-early protein ICP0 regulates the herpes simplex virus by activating viral gene expression thereby initiating lytic infection. Cellular proteins are degraded by ICP0, promoting the virus to enter the lytic cycle. …
Sleep Patterns In Collegiate Dancers, Beth Nicks, Jacque Price
Sleep Patterns In Collegiate Dancers, Beth Nicks, Jacque Price
e-Research: A Journal of Undergraduate Work
As college dance majors, the investigators have witnessed firsthand the effects that sleep and the lack thereof can have on the performance quality of University level dancing. It has been shown that lack of sleep can compromise nearly every physiological process such as memory, coordination, metabolism, and new learning (Wozny 2008). Studies on disruptions of the human circadian rhythms have shown that athletes involved in endeavors where sleep is restricted or totally deprived have severe consequences on behavior and performance. (Edwards 2007). However, the environment of college dance programs is different than athletics due to there being no off season. …
Treating Cocaine Dependency With Psychopharmacotherapy And Behavioral Therapy, Robyn Liebman
Treating Cocaine Dependency With Psychopharmacotherapy And Behavioral Therapy, Robyn Liebman
e-Research: A Journal of Undergraduate Work
Cocaine is an addictive drug that affects more than 14 million people globally, according to the United Nations. This paper is a conceptual meta-analysis of numerous studies that tested the effects of psychopharmacological therapy along with behavioral therapy in the treatment of cocaine addiction. It is hypothesized that cocaine dependent individuals treated with a combination of psychopharmacological and behavioral therapies will be less likely to use cocaine. Measurements of cocaine use throughout the experiments were generally assessed by urine screenings. Results indicate that there is more evidence that a combination of psychopharmacological and behavioral therapies will reduce cocaine use. There …
The Effect Of Pomegranate Juice Extract On The Hedgehog Signaling Pathway In Pancreatic Cancer, Veronica Gomez, Talia Shackelford, Autumn Tocchi, Melissa Rowland-Goldsmith
The Effect Of Pomegranate Juice Extract On The Hedgehog Signaling Pathway In Pancreatic Cancer, Veronica Gomez, Talia Shackelford, Autumn Tocchi, Melissa Rowland-Goldsmith
e-Research: A Journal of Undergraduate Work
Pancreatic cancer is the fourth leading cause of cancer death in the United States. There have been several reports indicating that phytochemicals in fruits can reduce the risk of cancer due to the anti-oxidant and anti-inflammatory effects of the polyphenols. Our lab has shown that pomegranate juice extract (PJE) has anti-proliferative and pro-apoptotic effects in human pancreatic cancer cells. In the past, we have shown that cells adhere more strongly to the plate when treated with PJE. This observation prompted an investigation of how PJE regulates cell adhesion proteins. Previously, our lab investigated E-cadherin, a cell adhesion protein. Upon activation …
Effects Of Ocean Acidification On Chlorophyll Content, C. Del Fierro, R. Lloyd, H. El-Askary
Effects Of Ocean Acidification On Chlorophyll Content, C. Del Fierro, R. Lloyd, H. El-Askary
e-Research: A Journal of Undergraduate Work
Airborne pollutants contribute to ocean acidification and hence to the associated chlorophyll content level. Previous work showed that falling aerosols causing ocean acidification would in turn result in bleaching and productivity loss in coral reef builders. Chlorophyll content has been used as a measure of the concentration of the photosynthetic pigment chlorophyll a (the most common "green" chlorophyll) in the ocean. In our work we have monitored the change in chlorophyll content obtained from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor on board Terra/Aqua satellites from 2000-2009 over selected pilot areas. Moreover, we have used the Goddard Chemistry Aerosol Radiation …
Haplotype Variety Analysis Of Human Populations: An Application To Hapmap Data, Michelle Creek, Cyril Rakovski
Haplotype Variety Analysis Of Human Populations: An Application To Hapmap Data, Michelle Creek, Cyril Rakovski
e-Research: A Journal of Undergraduate Work
We undertake a study to investigate the haplotype variety of distinct human populations. We use a natural measure of haplotype variety, the total number of haplotypes (TNH) present that reflects the number of haplotypes with nonzero frequencies estimated from the data at hand for each selection of multiple loci. For the analysis of real human populations, we use the haplotype data of the Denver Chinese, Tuscan Italians, Luhya Kenyans, and Gujarati Indians from release III of the HapMap database. Moreover, we show that the TNH statistic is biased in small sample data scenarios such as the HapMap and implement a …
On The Ranking Of The Disease Susceptibility Locus In Family-Based Candidate Gene Studies: A Simulation-Based Analysis, Lisa A. Brown, Cyril Rakovski
On The Ranking Of The Disease Susceptibility Locus In Family-Based Candidate Gene Studies: A Simulation-Based Analysis, Lisa A. Brown, Cyril Rakovski
e-Research: A Journal of Undergraduate Work
The ranking of the p-value of the true causal single nucleotide polymorphism in the ordered list of individual SNP p-values is an important factor for achieving success in the ultimate objective of association studies - identifying deleterious genetic variants. Thus, we undertake a study to assess the implications of complex, multimarker correlation structure, sample size and disease models on the ranking of the causal SNP. We carry out an extensive family-based candidate gene simulation study to analyze the position of the disease susceptibility locus in the complete list of individual SNP p-values ordered according to their statistical significance. We simulate …