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Induced Pluripotent Stem Cells As Tools For Disease Modelling And Drug Discovery In Alzheimer's Disease, Lezanne Ooi, Kuldip Sidhu, Anne Poljak, Greg Sutherland, Michael D. O'Connor, Perminder Sachdev, Gerald Munch Jan 2013

Induced Pluripotent Stem Cells As Tools For Disease Modelling And Drug Discovery In Alzheimer's Disease, Lezanne Ooi, Kuldip Sidhu, Anne Poljak, Greg Sutherland, Michael D. O'Connor, Perminder Sachdev, Gerald Munch

Faculty of Science - Papers (Archive)

Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder that leads to a progressive decline in a person’s memory and ability to communicate and carry out daily activities. The brain pathology in AD is characterized by extensive neuronal loss, particularly of cholinergic neurons, intracellular neurofibrillary tangles composed of the tau protein (NFTs) and extracellular deposition of plaques composed of β-amyloid (Aβ), a cleavage product of the amyloid precursor protein (APP). These two insoluble protein aggregates are accompanied by a chronic inflammatory response and extensive oxidative damage. Whereas dys-regulation of APP expression or processing appears to be important for ...


A Reagentless Thermal Post-Synthetic Rearrangement Of An Allyloxy-Tagged Metal-Organic Framework, Andrew D. Burrows, Sally O. Hunter, Mary F. Mahon, Christopher Richardson Jan 2013

A Reagentless Thermal Post-Synthetic Rearrangement Of An Allyloxy-Tagged Metal-Organic Framework, Andrew D. Burrows, Sally O. Hunter, Mary F. Mahon, Christopher Richardson

Faculty of Science - Papers (Archive)

Direct heating of a metal-organic framework provides a simple, controllable way of effecting a covalent post-synthetic modification. Herein we report that an allyloxy-tagged zinc metal-organic framework undergoes a thermally-promoted aromatic Claisen rearrangement through which the framework connectivity and porosity are maintained.


Ten Trenches: A Scienceart Collaboration, Timothy J. Cohen, Martin Cohen, Stephanie Kermode, Michael G. Leggett Jan 2013

Ten Trenches: A Scienceart Collaboration, Timothy J. Cohen, Martin Cohen, Stephanie Kermode, Michael G. Leggett

Faculty of Science - Papers (Archive)

Collaborative and cross-disciplinary research by a group of artists and scientists in an Australian rural setting generates data and ideas that form the basis of a wider understanding of the ramifications of global warming and cooling within the local, regional and national community. The work is viewed as an initial educational platform that will allow the public to see and understand the complexities of climate-based research.


Bryophyte Species Composition Over Moisture Gradients In The Windmill Islands, East Antarctica: Development Of A Baseline For Monitoring Climate Change Impacts, J Wasley, S A. Robinson, J D. Turnbull, D H. King, W Wanek, M Popp Oct 2012

Bryophyte Species Composition Over Moisture Gradients In The Windmill Islands, East Antarctica: Development Of A Baseline For Monitoring Climate Change Impacts, J Wasley, S A. Robinson, J D. Turnbull, D H. King, W Wanek, M Popp

Faculty of Science - Papers (Archive)

Extreme environmental conditions prevail on the Antarctic continent and limit plant diversity to cryptogamic communities, dominated by bryophytes and lichens. Even small abiotic shifts, associated with climate change, are likely to have pronounced impacts on these communities that currently exist at their physiological limit of survival. Changes to moisture availability, due to precipitation shifts or alterations to permanent snow reserves, will most likely cause greatest impact. In order to establish a baseline for determining the effect of climate change on continental Antarctic terrestrial communities and to better understand bryophyte species distributions in relation to moisture in a floristically important Antarctic ...


The Isolation Of Bioactive Flavonoids From Jacaranda Obtusifolia H. B. K. Ssp. Rhombifolia (G. F. W. Meijer) Gentry, Sorachai Khamsan, Saisunee Liawruangrath, Aphiwat Teerawutkulrag, Stephen G. Pyne, Mary J. Garson, Boonsom Liawruangrath Jun 2012

The Isolation Of Bioactive Flavonoids From Jacaranda Obtusifolia H. B. K. Ssp. Rhombifolia (G. F. W. Meijer) Gentry, Sorachai Khamsan, Saisunee Liawruangrath, Aphiwat Teerawutkulrag, Stephen G. Pyne, Mary J. Garson, Boonsom Liawruangrath

Faculty of Science - Papers (Archive)

The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. The structures were elucidated based on 1H, 13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds 1 and 3 were demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50 values of 30.1 and 16.6 μg mL-1, respectively. The isolates were non-cytotoxic to Vero cells (African green ...


Translocation Of The Eastern Bristlebird 1: Radio-Tracking Of Post-Release Movements, David Bain, Kris French, Jack Baker, Jean Clarke May 2012

Translocation Of The Eastern Bristlebird 1: Radio-Tracking Of Post-Release Movements, David Bain, Kris French, Jack Baker, Jean Clarke

Faculty of Science - Papers (Archive)

Translocating birds to a new area of habitat to restore or supplement depleted populations may pose a significant threat to the translocated individuals. While for many species, translocated individuals appear to move larger distances than resident animals, species with poor dispersal capacity may be restricted in movements and translocation methods may need to accommodate differences in movements to ensure success. In this study, designed to provide insights to inform our broader programme of translocations in New South Wales, Australia, we investigated post-release movements in the endangered, semi-flightless Eastern Bristlebird (Dasyornis brachypterus). We predicted that movements would be minimal, with few ...


Manufacturing On The Move? Beyond The High Dollar In The Debate About Making Things In Australia - The Case Of The Australian Surfboard Industry - Ausccer Discussion Paper No. 2012/2, Andrew Warren, Chris Gibson May 2012

Manufacturing On The Move? Beyond The High Dollar In The Debate About Making Things In Australia - The Case Of The Australian Surfboard Industry - Ausccer Discussion Paper No. 2012/2, Andrew Warren, Chris Gibson

Faculty of Science - Papers (Archive)

In October 2011 surfboard manufacturer BASE abruptly closed its factory on the Gold Coast resulting in the direct loss of 50 jobs. A few days later, nearby D’Arcy Surfboards also announced it was shedding workers and downsizing from a state-of-the art purpose built factory into a backyard workshop. Each business exported surfboards internationally and employed some of Australia’s best known surfboard-makers. The troubles facing these workshops added to those brewing at the very same in Australia’s steel, aluminium, automotive and garment industries. With renewed public debate and media commentary on the future of manufacturing, we now face ...


Process-Evaluation Of Tropospheric Humidity Simulated By General Circulation Models Using Water Vapor Isotopologues: 1. Comparison Between Models And Observations, Camille Risi, David Noone, John Worden, Christian Frankenberg, Gabriele Stiller, Michael Kiefer, Bernd Funke, Kaley Walker, Peter Bernath, Matthias Schneider, Debra Wunch, Vanessa Sherlock, Nicholas M. Deutscher, David W. Griffith, Paul O. Wennberg, Kimberly Strong, Dan Smale, Emmanuel Mahieu, Sabine Barthlott, Frank Hase, Omar Garcia, Justus Notholt, Thorsten Warneke, Geoffrey Toon, David Sayres, Sandrine Bony, Jeonghoon Lee, Derek Brown, Ryu Uemura, Christophe Sturm Mar 2012

Process-Evaluation Of Tropospheric Humidity Simulated By General Circulation Models Using Water Vapor Isotopologues: 1. Comparison Between Models And Observations, Camille Risi, David Noone, John Worden, Christian Frankenberg, Gabriele Stiller, Michael Kiefer, Bernd Funke, Kaley Walker, Peter Bernath, Matthias Schneider, Debra Wunch, Vanessa Sherlock, Nicholas M. Deutscher, David W. Griffith, Paul O. Wennberg, Kimberly Strong, Dan Smale, Emmanuel Mahieu, Sabine Barthlott, Frank Hase, Omar Garcia, Justus Notholt, Thorsten Warneke, Geoffrey Toon, David Sayres, Sandrine Bony, Jeonghoon Lee, Derek Brown, Ryu Uemura, Christophe Sturm

Faculty of Science - Papers (Archive)

[1] The goal of this study is to determine how H2O and HDO measurements in water vapor can be used to detect and diagnose biases in the representation of processes controlling tropospheric humidity in atmospheric general circulation models (GCMs). We analyze a large number of isotopic data sets (four satellite, sixteen ground-based remote-sensing, five surface in situ and three aircraft data sets) that are sensitive to different altitudes throughout the free troposphere. Despite significant differences between data sets, we identify some observed HDO/H2O characteristics that are robust across data sets and that can be used to evaluate models. We ...


The Role Of Streptokinase As A Virulence Determinant Of Streptococcus Pyogenes - Potential For Therapeutic Targeting, Jason D. Mcarthur, Simon M. Cook, Carola Venturini, Mark J. Walker Mar 2012

The Role Of Streptokinase As A Virulence Determinant Of Streptococcus Pyogenes - Potential For Therapeutic Targeting, Jason D. Mcarthur, Simon M. Cook, Carola Venturini, Mark J. Walker

Faculty of Science - Papers (Archive)

Streptococcus pyogenes is a major human pathogen responsible for numerous diseases ranging from uncomplicated skin and throat infections to severe, life threatening invasive disease such as necrotising fasciitis and streptococcal toxic shock syndrome. These severe invasive infections progress rapidly and produce high rates of morbidity and mortality despite the implementation of aggressive treatment plans. The activation of plasminogen and the acquisition of plasmin activity at the bacterial cell surface is critical for the invasive pathogenesis of this organism. To facilitate this process, S. pyogenes secrete streptokinase, a potent plasminogen activating protein. Here, we describe the role of streptokinase in invasive ...


Seed Bank Persistence And Climate Change, Mark K. J Ooi Feb 2012

Seed Bank Persistence And Climate Change, Mark K. J Ooi

Faculty of Science - Papers (Archive)

"The strong mechanistic relationship between climatic factors and seed dormancy and germination suggests that forecast climatic changes will significantly affect seed bank persistence. This review focuses on the potential impact of changing temperature, rainfall and fire regimes on the longevity of long-term persistent seed-banks. Currently, there are few studies investigating the mechanistic responses of demographic processes, such as seed-bank dynamics, to forecast climate change. However, from the work that has been published, several key points have been highlighted. First, increased air temperatures will produce significantly higher soil temperatures in open and sparsely vegetated habitats. Some evidence shows that this could ...


Roles Of Extracellular Chaperones In Amyloidosis, Amy R. Wyatt, Justin J. Yerbury, Rebecca A. Dabbs, Mark R. Wilson Jan 2012

Roles Of Extracellular Chaperones In Amyloidosis, Amy R. Wyatt, Justin J. Yerbury, Rebecca A. Dabbs, Mark R. Wilson

Faculty of Science - Papers (Archive)

Extracellular protein misfolding and aggregation underlie many of the most serious amyloidoses including Alzheimer's disease, spongiform encephalopathies and type II diabetes. Despite this, protein homeostasis (proteostasis) research has largely focussed on characterising systems that function to monitor protein conformation and concentration within cells. We are now starting to identify elements of corresponding systems, including an expanding family of secreted chaperones, which exist in the extracellular space. Like their intracellular counterparts, extracellular chaperones are likely to play a central role in systems that maintain proteostasis; however, the precise details of how they participate are only just emerging. It is proposed ...


The Extracellular Chaperone Clusterin Sequesters Oligomeric Forms Of The Amyloid-Beta 1-40 Peptide, Priyanka Narayan, Angel Orte, Richard W. Clarke, Benedetta Bolognesi, Sharon Hook, Kristina A. Ganzinger, Sarah Meehan, Mark R. Wilson, Christopher M. Dobson, David Klenerman Jan 2012

The Extracellular Chaperone Clusterin Sequesters Oligomeric Forms Of The Amyloid-Beta 1-40 Peptide, Priyanka Narayan, Angel Orte, Richard W. Clarke, Benedetta Bolognesi, Sharon Hook, Kristina A. Ganzinger, Sarah Meehan, Mark R. Wilson, Christopher M. Dobson, David Klenerman

Faculty of Science - Papers (Archive)

In recent genome-wide association studies, the extracellular chaperone protein, clusterin, has been identified as a newly-discovered risk factor in Alzheimer's disease. We have examined the interactions between human clusterin and the Alzheimer's disease-associated amyloid-β 1-40 peptide (Aβ 1-40), which is prone to aggregate into an ensemble of oligomeric intermediates implicated in both the proliferation of amyloid fibrils and in neuronal toxicity. Using highly sensitive single-molecule fluorescence methods, we have found that Aβ 1-40 forms a heterogeneous distribution of small oligomers (from dimers to 50-mers), all of which interact with clusterin to form long-lived, stable complexes. Consequently, clusterin is ...


Investigating Arsenic Speciation And Mobilization In Sediments With Dgt And Det: A Mesocosm Evaluation Of Oxic-Anoxic Transitions, William W. Bennett, Peter R. Teasdale, Jarad G. Panther, David T. Welsh, Huijun Zhao, Dianne F. Jolley Jan 2012

Investigating Arsenic Speciation And Mobilization In Sediments With Dgt And Det: A Mesocosm Evaluation Of Oxic-Anoxic Transitions, William W. Bennett, Peter R. Teasdale, Jarad G. Panther, David T. Welsh, Huijun Zhao, Dianne F. Jolley

Faculty of Science - Papers (Archive)

Mobilization of arsenic from freshwater and estuarine sediments during the transition from oxic to anoxic conditions was investigated using recently developed diffusive sampling techniques. Arsenic speciation and Fe(II) concentrations were measured at high resolution (1−3 mm) with in situ diffusive gradients in thin films (DGT) and diffusive equilibration in thin films (DET) techniques. Water column anoxia induced Fe(II) and As(III) fluxes from the sediment. A correlation between water column Fe(II) and As(III) concentrations was observed in both freshwater (rs = 0.896, p < 0.001) and estuarine (rs = 0.557, p < 0.001) mesocosms. Porewater sampling by DGT and DET techniques confirmed that arsenic mobilization was associated with the reductive dissolution of Fe(III) (hydr)oxides in the suboxic zone of the sediment; a relationship that was visible because of the ability to measure the coincident profiles of these species using combined DGT and DET samplers. The selective measurement of As(III) and total inorganic arsenic by separate DGT samplers indicated that As(III) was the primary species mobilized from the solid phase to the porewater. This measurement approach effectively ruled out substantial As(V) mobilization from the freshwater and estuarine sediments in this experiment. This study demonstrates the capabilities of the DGT and DET techniques for investigating arsenic speciation and mobilization over a range of sediment conditions.


Conservation Planning In A Cross-Cultural Context: The Wunambal Gaambera Healthy Country Project In The Kimberley, Western Australia, Heather Moorcroft, Emma Ignjic, Stuart Cowell, John Goonack, Sylvester Mangolomara, Janet Oobagooma, Regina Karadada, Dianna Williams, Neil Waina Jan 2012

Conservation Planning In A Cross-Cultural Context: The Wunambal Gaambera Healthy Country Project In The Kimberley, Western Australia, Heather Moorcroft, Emma Ignjic, Stuart Cowell, John Goonack, Sylvester Mangolomara, Janet Oobagooma, Regina Karadada, Dianna Williams, Neil Waina

Faculty of Science - Papers (Archive)

This article illustrates how a conservation planning approach combined Indigenous knowledge and Western science to support Indigenous Traditional Owners to make decisions about managing their ancestral lands and seas, and communicate more strategically with external stakeholders.


Changes In Forest Structure Over 60 Years: Tree Densities Continue To Increase In The Pilliga Forests, New South Wales, Australia, Robyn K. Whipp, I D. Lunt, Peter G. Spooner, Ross A. Bradstock Jan 2012

Changes In Forest Structure Over 60 Years: Tree Densities Continue To Increase In The Pilliga Forests, New South Wales, Australia, Robyn K. Whipp, I D. Lunt, Peter G. Spooner, Ross A. Bradstock

Faculty of Science - Papers (Archive)

"Studies of long-term vegetation changes are critical for enhancing our understanding of successional dynamics in natural ecosystems. Bycomparing forest inventory data from the 1940s against field data from 2005, we document changes in stand structure over 60 years in forests co-dominated by Callitris glaucophylla J. Thompson & L. Johnson, Allocasuarina luehmannii (R. Baker) L. Johnson and Eucalyptus crebra F.Muell., in central Pilliga, New South Wales (NSW), Australia. Sampling was stratified across two forest types and across a 1951 wildfire boundary, to assess the effects of initial stand structure and early disturbance on stand dynamics. Stems in the size range tallied ...


Doing Participatory Action Research And Doing A Phd: Words Of Encouragement For Prospective Students, Natascha Klocker Jan 2012

Doing Participatory Action Research And Doing A Phd: Words Of Encouragement For Prospective Students, Natascha Klocker

Faculty of Science - Papers (Archive)

No abstract provided.


Architecture And Conservation Of The Bacterial Dna Replication Machinery, An Underexploited Drug Target, Andrew Robinson, Rebecca J. Causer, Nicholas E. Dixon Jan 2012

Architecture And Conservation Of The Bacterial Dna Replication Machinery, An Underexploited Drug Target, Andrew Robinson, Rebecca J. Causer, Nicholas E. Dixon

Faculty of Science - Papers (Archive)

"New antibiotics with novel modes of action are required to combat the growing threat posed by multi-drug resistant bacteria. Over the last decade, genome sequencing and other high-throughput techniques have provided tremendous insight into the molecular processes underlying cellular functions in a wide range of bacterial species. We can now use these data to assess the degree of conservation of certain aspects of bacterial physiology, to help choose the best cellular targets for development of new broad-spectrum antibacterials. DNA replication is a conserved and essential process, and the large number of proteins that interact to replicate DNA in bacteria are ...


Synthesis Of Stemofoline Analogues As Acetylcholinesterase Inhibitors, Kwankamol Sastraruji, Thanapat Sastraruji, Alison T. Ung, Renate Griffith, Araya Jatisatienr, Stephen G. Pyne Jan 2012

Synthesis Of Stemofoline Analogues As Acetylcholinesterase Inhibitors, Kwankamol Sastraruji, Thanapat Sastraruji, Alison T. Ung, Renate Griffith, Araya Jatisatienr, Stephen G. Pyne

Faculty of Science - Papers (Archive)

Thirty two new stemofoline analogues were prepared from didehydrostemofoline for studies as AChE inhibitors. C-3 side-chain modified amino, carbamate, triazole and oxazole stemofoline derivatives were prepared. In general the amine derivatives were found to be stronger inhibitors of AChE than their alcohol analogues that we previously reported. Compounds 5 and 26, with small C-3 side chain substituents, were two of the most active inhibitors. Preliminary molecular docking studies suggested that these compounds may inhibit AChE by binding horizontally along the passage of the active-site gorge and block access to acetylcholine.


Cnt/Conducting Polymer Composite Conductors Impart High Flexibility To Textile Electroluminescent Devices, Bin Hu, Dapeng Li, Prakash Manandharm, Qinguo Fan, Dayalan Kasilingam, Paul D. Calvert Jan 2012

Cnt/Conducting Polymer Composite Conductors Impart High Flexibility To Textile Electroluminescent Devices, Bin Hu, Dapeng Li, Prakash Manandharm, Qinguo Fan, Dayalan Kasilingam, Paul D. Calvert

Faculty of Science - Papers (Archive)

Highly transparent polyethylene terephthalate (PET) mesh fabrics were dip coated with carbon nanotubes (CNT) followed by inkjet printing with poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) to develop textile-based CNT/PEDOT:PSS composite conductors. These coated fabrics show a combination of conductivity, transparency and flexibility suitable for use in flexible displays. Sequential CNT and PEDOT:PSS coating greatly enhances the conductivity at high tensile strains without reducing the optical transparency. Electroluminescent (EL) devices using such textile-based CNT/PEDOT:PSS composite conductors as the front electrodes exhibit superior flexibility and mechanical robustness over their ITO-coated PET film-based counterparts under stretching ...


Seasonal Field Metabolic Rate And Water Influx Of Captive-Bred Reintroduced Yellow-Footed Rock-Wallabies (Petrogale Xanthopus Celeris), Steven J. Lapidge, Adam J. Munn Jan 2012

Seasonal Field Metabolic Rate And Water Influx Of Captive-Bred Reintroduced Yellow-Footed Rock-Wallabies (Petrogale Xanthopus Celeris), Steven J. Lapidge, Adam J. Munn

Faculty of Science - Papers (Archive)

Captive breeding and release is a tool used by conservation biologists to re-establish populations of endangered or locally extinct species. Reintroduced animals that have been bred in captivity must learn to meet the challenges posed by free living, and to adjust to local environmental conditions, food and water sources. How well reintroduced animals might meet these challenges is uncertain as few longitudinal studies have investigated the physiology of reintroduced animals or the implications of this for successful establishment of new populations. Here we have evaluated long-term, seasonal energy and water use by reintroduced yellow-footed rock-wallabies (Petrogale xanthopus celeris), an endangered ...


Validation Of Iasi Forli Carbon Monoxide Retrievals Using Ftir Data From Ndacc, T Kerzenmacher, B Dils, N Kumps, T Blumenstock, C Clerbaux, P F. Coheur, P Demoulin, Omaira Garcia, M George, David W. Griffith, F Hase, J Hadji-Lazaro, D Hurtmans, Nicholas B. Jones, E Mahieu, Justus Notholt, Clare Paton-Walsh, U Raffalski, T Ridder, M Schneider, C Servais, M De Maziere Jan 2012

Validation Of Iasi Forli Carbon Monoxide Retrievals Using Ftir Data From Ndacc, T Kerzenmacher, B Dils, N Kumps, T Blumenstock, C Clerbaux, P F. Coheur, P Demoulin, Omaira Garcia, M George, David W. Griffith, F Hase, J Hadji-Lazaro, D Hurtmans, Nicholas B. Jones, E Mahieu, Justus Notholt, Clare Paton-Walsh, U Raffalski, T Ridder, M Schneider, C Servais, M De Maziere

Faculty of Science - Papers (Archive)

Carbon monoxide (CO) is retrieved daily and globally from space-borne IASI radiance spectra using the Fast Optimal Retrievals on Layers for IASI (FORLI) software developed at the Universit´e Libre de Bruxelles (ULB). The IASI CO total column product for 2008 from the most recent FORLI retrieval version (20100815) is evaluated using correlative CO profile products retrieved from groundbased solar absorption Fourier transform infrared (FTIR) observations at the following FTIR spectrometer sites from the Network for the Detection of Atmospheric Composition Change (NDACC): Ny-A° lesund, Kiruna, Bremen, Jungfraujoch, Iza˜na and Wollongong. In order to have good statistics for the ...


Soil Chemistry: Understanding Phosphorus In The Environment, Paul Milham, Warwick Dougherty, Robert John Morrison, Robert Graham Clark, Ronald Smernik, Ashlea Doolette, Lucy Burkitt, Damian Collins, Rebeca Alvarez, Andrew Thomas Jan 2012

Soil Chemistry: Understanding Phosphorus In The Environment, Paul Milham, Warwick Dougherty, Robert John Morrison, Robert Graham Clark, Ronald Smernik, Ashlea Doolette, Lucy Burkitt, Damian Collins, Rebeca Alvarez, Andrew Thomas

Faculty of Science - Papers (Archive)

It is an essential ingredient in food production, but poor management means bad news downstream. Understanding the way phosphorus behaves in the environment calls for soil and plant biology, and some new soil chemistry.


Gelapin, A Degradable Genipin Cross-Linked Gelatin Hydrogel, Damian Kirchmajer, C Watson, Marie Ranson, Marc In Het Panhuis Jan 2012

Gelapin, A Degradable Genipin Cross-Linked Gelatin Hydrogel, Damian Kirchmajer, C Watson, Marie Ranson, Marc In Het Panhuis

Faculty of Science - Papers (Archive)

The synthesis of genipin cross-linked gelatin (Gelapin) hydrogel materials is presented. Gelapin hydrogels were comprehensively characterised through chemical, mechanical and physical analysis techniques. It was found that the hydrogels could be cross-linked to up to 90% using a genipin concentration of 24.4% (w/ w). The hydrogels reach a stable swollen state and cease leaching of residual starting materials after 72 h in phosphate buffered saline solution at 37 uC. The proteolytic degradation of Gelapin by collagenase is tuneable through manipulation of the material composition with the rate of degradation ranging from 60 mg per day up to 500 mg ...


Beyond Barcoding: A Mitochondrial Genomics Approach To Molecular Phylogenetics And Diagnostics Of Blowflies (Diptera: Calliphoridae), Leigh Nelson, Christine L. Lambkin, Philip Batterham, James F. Wallman, Mark P. Dowton, Michael F. Whiting, David K. Yeates, Stephen L. Cameron Jan 2012

Beyond Barcoding: A Mitochondrial Genomics Approach To Molecular Phylogenetics And Diagnostics Of Blowflies (Diptera: Calliphoridae), Leigh Nelson, Christine L. Lambkin, Philip Batterham, James F. Wallman, Mark P. Dowton, Michael F. Whiting, David K. Yeates, Stephen L. Cameron

Faculty of Science - Papers (Archive)

Members of the Calliphoridae (blowflies) are significant for medical and veterinary management, due to the ability of some species to consume living flesh as larvae, and for forensic investigations due to the ability of others to develop in corpses. Due to the difficulty of accurately identifying larval blowflies to species there is a need for DNA-based diagnostics for this family, however the widely used DNA-barcoding marker, cox1, has been shown to fail for several groups within this family. Additionally, many phylogenetic relationships within the Calliphoridae are still unresolved, particularly deeper level relationships. Sequencing whole mt genomes has been demonstrated both ...


Atmospheric Carbon Dioxide Retrieved From The Greenhouse Gases Observing Satellite (Gosat): Comparison With Ground-Based Tccon Observations And Geos-Chem Model Calculations, A Cogan, H Boesch, R Parker, L Feng, Paul Palmer, J-F Blavier, Nicholas M. Deutscher, Ronald Macatangay, Justus Notholt, C M. Roehl, Thorsten Warneke, Debra Wunch Jan 2012

Atmospheric Carbon Dioxide Retrieved From The Greenhouse Gases Observing Satellite (Gosat): Comparison With Ground-Based Tccon Observations And Geos-Chem Model Calculations, A Cogan, H Boesch, R Parker, L Feng, Paul Palmer, J-F Blavier, Nicholas M. Deutscher, Ronald Macatangay, Justus Notholt, C M. Roehl, Thorsten Warneke, Debra Wunch

Faculty of Science - Papers (Archive)

We retrieved column-averaged dry air mole fractions of atmospheric carbon dioxide (XCO 2) from backscattered short-wave infrared (SWIR) sunlight measured by the Japanese Greenhouse gases Observing SATellite (GOSAT). Over two years of XCO 2 retrieved from GOSAT is compared with XCO 2 inferred from collocated SWIR measurements by seven ground-based Total Carbon Column Observing Network (TCCON) stations. The average difference between GOSAT and TCCON XCO 2 for individual TCCON sites ranges from -0.87 ppm to 0.77 ppm with a mean value of 0.1 ppm and standard deviation of 0.56 ppm. We find an average bias between ...


Australia's Black Saturday Fires - Comparison Of Techniques For Estimating Emissions From Vegetation Fires, Clare Paton-Walsh, Louisa K. Emmons, Christine Wiedinmyer Jan 2012

Australia's Black Saturday Fires - Comparison Of Techniques For Estimating Emissions From Vegetation Fires, Clare Paton-Walsh, Louisa K. Emmons, Christine Wiedinmyer

Faculty of Science - Papers (Archive)

We present a comparison of techniques for estimating atmospheric emissions from fires using Australia's 2009 "Black Saturday" wildfires as a case study. Most of the fires started on Saturday the 7th of February 2009 (a date now known as "Black Saturday") and then spread rapidly, fanned by gale force winds, creating several firestorms and killing 173 people. The fires continued into early March, when rain and cooler conditions allowed the fires to be extinguished. In this study, we compare two new techniques (and one more established method) to estimate the total emissions of a number of atmospheric trace gases ...


Comparison Of Chemical Constituents And Antibacterial Activities And Antioxidant Activities Of The Essential Oil From Leaves And Fruits Of Bridelia Retusa (L.) A. Juss, D Sanseera, W Niwatananun, Saisunee Liawruangrath, Apiwat Baramee, Banyong Khantawa, Stephen G. Pyne, Boonsom Liawruangrath Jan 2012

Comparison Of Chemical Constituents And Antibacterial Activities And Antioxidant Activities Of The Essential Oil From Leaves And Fruits Of Bridelia Retusa (L.) A. Juss, D Sanseera, W Niwatananun, Saisunee Liawruangrath, Apiwat Baramee, Banyong Khantawa, Stephen G. Pyne, Boonsom Liawruangrath

Faculty of Science - Papers (Archive)

The essential oils from the leaves and fruits of Bridelia retusa (L.) A.Juss. were isolated by hydrodistillation. The essential oils were obtained in 0.0013% yield as a pale yellow liquid and 0.0026% yield as a violet-light brown liquid for the leaf oil and fruit oil respectively. The composition of each essential oil was analysed by means of GC-(FID) and GC-MS. Eleven constituents accounting for 48.77% of total leaves oil were identified. The most abundant compound was phytol (33.4%), followed by phthalic acid (5.2%), 6, 13-dimethoxy-2, 3, 9, 10-tetramethylpentacene-1, 4, 8, 11-tetrone (3.4 ...


Behavioural Adaptation Of A Bird From Transient Wetland Specialist To An Urban Resident, John Martin, Kristine O. French, Richard Major Jan 2012

Behavioural Adaptation Of A Bird From Transient Wetland Specialist To An Urban Resident, John Martin, Kristine O. French, Richard Major

Faculty of Science - Papers (Archive)

Dramatic population increases of the native white ibis in urban areas have resulted in their classification as a nuisance species. In response to community and industry complaints, land managers have attempted to deter the growing population by destroying ibis nests and eggs over the last twenty years. However, our understanding of ibis ecology is poor and a question of particular importance for management is whether ibis show sufficient site fidelity to justify site-level management of nuisance populations. Ibis in non-urban areas have been observed to be highly transient and capable of moving hundreds of kilometres. In urban areas the population ...


Hominin Dispersal Into The Nefud Desert And Middle Palaeolithic Settlement Along The Jubbah Palaeolake, Northern Arabia, M Petraglia, Abdullah M. Alsharekh, P Breeze, Christopher Clarkson, Remy Crassard, Nick A. Drake, Huw Groucutt, R Jennings, Adrian Parker, A Parton, Richard Roberts, C Shipton, Carney Matheson, A Al-Omari, M Veall Jan 2012

Hominin Dispersal Into The Nefud Desert And Middle Palaeolithic Settlement Along The Jubbah Palaeolake, Northern Arabia, M Petraglia, Abdullah M. Alsharekh, P Breeze, Christopher Clarkson, Remy Crassard, Nick A. Drake, Huw Groucutt, R Jennings, Adrian Parker, A Parton, Richard Roberts, C Shipton, Carney Matheson, A Al-Omari, M Veall

Faculty of Science - Papers (Archive)

The Arabian Peninsula is a key region for understanding hominin dispersals and the effect of climate change on prehistoric demography, although little information on these topics is presently available owing to the poor preservation of archaeological sites in this desert environment. Here, we describe the discovery of three stratified and buried archaeological sites in the Nefud Desert, which includes the oldest dated occupation for the region. The stone tool assemblages are identified as a Middle Palaeolithic industry that includes Levallois manufacturing methods and the production of tools on flakes. Hominin occupations correspond with humid periods, particularly Marine Isotope Stages 7 ...


Evidence Of Enso Mega-Drought Triggered Collapse Of Prehistory Aboriginal Society In Northwest Australia, Hamish Mcgowan, Samuel K. Marx, P Moss, Andrew Hammond Jan 2012

Evidence Of Enso Mega-Drought Triggered Collapse Of Prehistory Aboriginal Society In Northwest Australia, Hamish Mcgowan, Samuel K. Marx, P Moss, Andrew Hammond

Faculty of Science - Papers (Archive)

The Kimberley region of northwest Australia contains one of the World's largest collections of rock art characterised by two distinct art forms; the fine featured anthropomorphic figures of the Gwion Gwion or Bradshaw paintings, and broad stroke Wandjina figures. Luminescence dating of mud wasp nests overlying Gwion Gwion paintings has confirmed an age of at least 17,000 yrs B.P. with the most recent dates for these paintings from around the mid-Holocene (5000 to 7000 yrs B.P.). Radiocarbon dating indicates that the Wandjina rock art then emerged around 3800 to 4000 yrs B.P. following a hiatus ...