Life Sciences Commons^™

The Mir-51 Family Of Micrornas Functions In Diverse Regulatory Pathways In Caenorhbditis Elegans, Allison L. Abbott, John L. Brenner, Benedict J. Kemp

Biological Sciences Faculty Research and Publications

The mir-51 family of microRNAs (miRNAs) in C. elegans are part of the deeply conserved miR-99/100 family. While loss of all six family members (mir-51-56) in C. elegans results in embryonic lethality, loss of individual mir-51 family members results in a suppression of retarded developmental timing defects associated with the loss of alg-1. The mechanism of this suppression of developmental timing defects is unknown. To address this, we characterized the function of the mir-51 family in the developmental timing pathway. We performed genetic analysis and determined that mir-51 family members regulate the developmental timing pathway in the L2 stage …