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Full-Text Articles in Life Sciences
Endoplasmic Reticulum Stress Induces Axon Initial Segment Shortening In Cortical Neuron Culture, Jennae Shelby, Ryan B. Griggs, Josef Steinbrunner, Keiichiro Susuki
Endoplasmic Reticulum Stress Induces Axon Initial Segment Shortening In Cortical Neuron Culture, Jennae Shelby, Ryan B. Griggs, Josef Steinbrunner, Keiichiro Susuki
Medical Student Research Symposium Abstracts and Posters
The axon initial segment (AIS) is a domain located between the neuronal soma and axon responsible for action-potential initiation. Because even small changes in its length or location alter neuronal excitability and function, the AIS is a key structure for neurodegenerative pathophysiology. AIS shortening is seen in several neurodegenerative conditions such as traumatic brain injury, Alzheimer’s disease, neuropathic pain, multiple sclerosis, and diabetic encephalopathy. Diabetic encephalopathy refers to mild cognitive impairment or dementia often experienced in patients with type 2 diabetes. Although patients with type 2 diabetes are 1.73 times more likely to develop dementia, there is currently no course …
Placental Hypoxia-Inducible Factor 1 Alpha In Early-Onset Preeclampsia As A Predictor Of Future Risk In Maternal And Fetal Health, Julie Slyby, Bryce Linkous, Sarah Scott, Chandni Chandiramani, Amy Hwang, Danielle Spanbauer, Melissa R. Kaufman, Traci Rackett, Kailey Nolan, Emily Stone, Rose A. Maxwell, David N. Dhanraj, Thomas L. Brown
Placental Hypoxia-Inducible Factor 1 Alpha In Early-Onset Preeclampsia As A Predictor Of Future Risk In Maternal And Fetal Health, Julie Slyby, Bryce Linkous, Sarah Scott, Chandni Chandiramani, Amy Hwang, Danielle Spanbauer, Melissa R. Kaufman, Traci Rackett, Kailey Nolan, Emily Stone, Rose A. Maxwell, David N. Dhanraj, Thomas L. Brown
Medical Student Research Symposium Abstracts and Posters
Preeclampsia is a life-threatening, pregnancy-associated disorder characterized by the rapid development of hypertension with renal dysfunction. While preeclampsia generally occurs later in pregnancy, early-onset preeclampsia (EOPE) can occur much earlier and is usually more devastating. Early-onset preeclampsia is also associated with an increased risk of maternal cardiovascular and metabolic disease in mothers later in life and neurocognitive dysfunction in their offspring. EOPE is strongly associated with abnormal placental development and fetal growth restriction during pregnancy.