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Full-Text Articles in Life Sciences
Ranking Viruses: Measures Of Positional Importance Within Networks Define Core Viruses For Rational Polyvalent Vaccine Development, Tavis K. Anderson, William W. Laegreid, Francesco Cerutti, Fernando A. Osorio, Eric A. Nelson, Jane Christopher-Hennings, Tony L. Goldberg
Ranking Viruses: Measures Of Positional Importance Within Networks Define Core Viruses For Rational Polyvalent Vaccine Development, Tavis K. Anderson, William W. Laegreid, Francesco Cerutti, Fernando A. Osorio, Eric A. Nelson, Jane Christopher-Hennings, Tony L. Goldberg
Virology Papers
Motivation: The extraordinary genetic and antigenic variability of RNA viruses is arguably the greatest challenge to the development of broadly effective vaccines. No single viral variant can induce sufficiently broad immunity, and incorporating all known naturally circulating variants into one multivalent vaccine is not feasible. Further, no objective strategies currently exist to select actual viral variants that should be included or excluded in polyvalent vaccines.
Results: To address this problem, we demonstrate a method based upon graph theory that quantifies the relative importance of viral variants. We demonstrate our method through application to the envelope glycoprotein gene of a particularly …