Life Sciences Commons^™

Controlling Feeding Behavior By Chemical Or Gene-Directed Targeting In The Brain: What’S So Spatial About Our Methods?, Arshad Khan

Arshad M. Khan, Ph.D.

Intracranial chemical injection (ICI) methods have been used to identify the locations in the brain where feeding behavior can be controlled acutely. Scientists conducting ICI studies often document their injection site locations, thereby leaving kernels of valuable location data for others to use to further characterize feeding control circuits. Unfortunately, this rich dataset has not yet been formally contextualized with other published neuroanatomical data. In particular, axonal tracing studies have delineated several neural circuits originating in the same areas where ICI injection feeding-control sites have been documented, but it remains unclear whether these circuits participate in feeding control. However, comparing …

Conservation In The Context Of Climate Change: Practical Guidelines For Land Protection At Local Scales, Kevin Ruddock, Peter August, Christopher Damon, Charles Labash, Pamela Rubinoff, Donald Robadue Jr.

Peter August

Climate change will affect the composition of plant and animal communities in many habitats and geographic settings. This presents a dilemma for conservation programs – will the portfolio of protected lands we now have achieve a goal of conserving biodiversity in the future when the ecological communities occurring within them change? Climate change will significantly alter many plant communities, but the geophysical underpinnings of these landscapes, such as landform, elevation, soil, and geological properties, will largely remain the same. Studies show that extant landscapes with a diversity of geophysical characteristics support diverse plant and animal communities. Therefore, geophysically diverse landscapes …

Definition Of An Hla-Dpw2-Restricted Epitope On Ns3, Recognized By A Dengue Virus Serotype-Cross-Reactive Human Cd4+ Cd8- Cytotoxic T-Cell Clone, Ichiro Kurane, Li Chen Dai, Peter G. Livingston, Elaine Reed, Francis A. Ennis

Li Dai

We previously reported that the clone JK34 was cross-reactive for dengue virus types 1, 2, 3, and 4 and recognized NS3 (I. Kurane, M. A. Brinton, A. L. Samson, and F. A. Ennis, J. Virol. 65:1823-1828, 1991). In the present experiments, we defined the epitope at the amino acid level, with 93 15-mer overlapping peptides which cover the entire NS3. A peptide 4 which contains amino acids 251 to 265 of NS3 sensitized the autologous B lymphoblastoid cell line (LCL) to the lysis by JK34. The smallest peptide recognized by JK34 was a 10-mer peptide which contains amino acids 255 …

Mutation Of Human Immunodeficiency Virus Type 1 At Amino Acid 585 On Gp41 Results In Loss Of Killing By Cd8+ A24-Restricted Cytotoxic T Lymphocytes, Li Chen Dai, Kim West, Rebecca A. Littaua, Kazuo Takahashi, Francis A. Ennis

Li Dai

A human leukocyte antigen A24-restricted CD8+ cytotoxic T-cell clone specific for gp41 of human immunodeficiency virus type 1 was isolated from an infected individual. The epitope was localized to amino acids 584 to 591 (YLKDQQLL, NL43 env sequence) of gp41 by using a panel of recombinant vaccinia viruses that contain truncated env genes and synthetic peptides. The clone killed autologous B-lymphoblastoid cell lines pulsed with a synthetic peptide reflecting the sequence of the IIIB and MN strains. This clone, however, failed to kill target cells pulsed with the peptides that have a mutation from Lys to Arg or Gln at …

A Prospective Study Of The Transient Decrease In Ovarian Cancer Risk Following Childbirth, Qin Liu, Mats Lambe, Inkyung Baik, Sven Cnattingius, Tomas Riman, Anders R. Ekbom, Hans-Olov Adami, Chung-Cheng Hsieh

Qin Liu

Epidemiologic evidence shows that the risk of ovarian cancer is decreased following childbirth. We examined the time points when the decreased risk of postpartum maternal ovarian cancer reaches the lowest point and whether the protective effect diminishes over time. A case-control study nested within the Swedish Fertility Register included 10,086 cases of epithelial ovarian cancer recorded in the Swedish Cancer Register from 1961 to 2001. From the Fertility Register, 49,249 eligible subjects matched to the cases by age were selected as controls. The analysis contrasted risk between adjacent parities through logistic regression models that included indicator variables representing each year …

Profiles Of Human Serum Antibody Responses Elicited By Three Leading Hiv Vaccines Focusing On The Induction Of Env-Specific Antibodies, Michael Vaine, Shixia Wang, Qin Liu, James Arthos, David C. Montefiori, Paul Goepfert, M. Juliana Mcelrath, Shan Lu

Qin Liu

In the current report, we compared the specificities of antibody responses in sera from volunteers enrolled in three US NIH-supported HIV vaccine trials using different immunization regimens. HIV-1 Env-specific binding antibody, neutralizing antibody, antibody-dependent cell-mediated cytotoxicity (ADCC), and profiles of antibody specificity were analyzed for human immune sera collected from vaccinees enrolled in the NIH HIV Vaccine Trial Network (HVTN) Study #041 (recombinant protein alone), HVTN Study #203 (poxviral vector prime-protein boost), and the DP6-001 study (DNA prime-protein boost). Vaccinees from HVTN Study #041 had the highest neutralizing antibody activities against the sensitive virus along with the highest binding antibody …

Correlation Of Umbilical Cord Blood Hormones And Growth Factors With Stem Cell Potential: Implications For The Prenatal Origin Of Breast Cancer Hypothesis, Todd M. Savarese, William C. Strohsnitter, Hoi Pang Low, Qin Liu, Inkyung Baik, William C. Okulicz, David P. Chelmow, Pagona Lagiou, Peter J. Quesenberry, Kenneth L. Noller, Chung-Cheng Hsieh

Qin Liu

INTRODUCTION: Prenatal levels of mitogens may influence the lifetime breast cancer risk by driving stem cell proliferation and increasing the number of target cells, and thereby increasing the chance of mutation events that initiate oncogenesis. We examined in umbilical cord blood the correlation of potential breast epithelial mitogens, including hormones and growth factors, with hematopoietic stem cell concentrations serving as surrogates of overall stem cell potential. METHODS: We analyzed cord blood samples from 289 deliveries. Levels of hormones and growth factors were correlated with concentrations of stem cell and progenitor populations (CD34+ cells, CD34+CD38- cells, CD34+c-kit+ cells, and granulocyte-macrophage colony-forming …

A Functional Notch-Survivin Gene Signature In Basal Breast Cancer, Connie Wing-Ching Lee, Karl Simin, Qin Liu, Janet Plescia, Minakshi Guha, Ashraf Khan, Chung-Cheng Hsieh, Dario C. Altieri

Qin Liu

INTRODUCTION: Basal-type, or triple-negative, breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 expression) is a high-risk disease for which no molecular therapies are currently available. We studied genetic signatures of basal breast cancer potentially suitable for therapeutic intervention. METHODS: We analyzed protein expression of the Notch-1 intracellular domain and survivin by immunohistochemistry in a series of basal breast cancer patients. A hierarchical clustering and overall survival analysis was carried out on a microarray mRNA database of 232 breast cancer patients. Fifteen published mRNA datasets containing estrogen receptor-negative or estrogen receptor-positive samples were subjected to meta-analysis …

Environmental And Socio-Economic Considerations For Aquaculture In Jervis Bay, Nsw, Alyssa Joyce, Ana M. Rubio, Pia C. Winberg

Dr Pia C Winberg

No abstract provided.

Impact Of Vehicular Traffic On Herpetofaunal Mortality In A Savannah Forest, Eastern Sri Lanka, Sujan Henkanaththegedara, Suranjan Karunarathna, A. A. Thasun Amarasinghe

Sujan Henkanaththegedara

Adult Mortality And Progeny Production Assessment Of Callosobruchus Maculatus (Coleoptera: Bruchidae) Exposed To Sayan®, Adel Khashaveh

Adel Khashaveh

The insecticidal efficacy of Sayan®, an Iranian formulation of diatomaceous earth, was evaluated against adults of Cowpea weevil, Callosobruchus maculatus (Coleoptera: Bruchidae) on cowpea. Sayan® was applied at the dose rates of 0.0, 0.1, 0.2, 0.5, 1.0 g/kg. One kg of cowpea was treated with appropriate dose rate and after one day, four samples of 50 g of each were taken as replication. Twenty five adults were introduced into each replication. The number of dead adults was counted after 24 and 72 h exposure. After mortality count, all surviving insects were removed and the samples retained under the same conditions …

La Diversidad De Los Analisis De Diversidad [The Diversity Of Diversity Analyses], Victor D. Carmona

Victor D. Carmona-Galindo

There is a lack of consistency with respect to the use of the terms like species richness, diversity and biodiversity, which extends to the analysis of diversity indices and the merit of using diversity indices in the evaluation (comparison and contrast) of biological communities. The purpose of this article is to provide working definitions for these terms and cite examples from the primary literature that demonstrate the utility of estimating richness, evaluating proportional abundance patterns, as well as comparing indices of diversity and similarity to study patterns of biological organization at different ecological scales. Additionally, we provide a manual in …

Phosphatidic Acid Interacts With A Myb Transcription Factor And Regulates Its Nuclear Localization And Function In Arabidopsis, Xuemin Wang, Hongyan Yao, Geliang Wang, Liang Guo

Xuemin (Sam) Wang

Applying Life Cycle Assessment (Lca) To Aquaculture: A Case Study Of The Tasmanian Salmon Industry, A White, Daryl Mcphee, Tor Hundloe

Daryl McPhee

No abstract provided.

Future Management And Governance Of The Queensland East Coast Inshore Finfish Fishery, Daryl Mcphee

Daryl McPhee

No abstract provided.

Marine Park Planning And Fisheries Management In Australia: Understanding The Conflict And Designing A Better Future, Daryl Mcphee

Daryl McPhee

No abstract provided.

Likely Effectiveness Of Netting Or Other Capture Programs As A Shark Hazard Mitigation Strategy Under Western Australian Conditions, Daryl Mcphee

Daryl McPhee

No abstract provided.

Impacts Of The Moreton Bay Marine Park Rezoning On Commercial Fishermen, Casper Van De Greer, Morena Mills, Vanessa Adams, Robert Pressey, Daryl Mcphee

Daryl McPhee

The design of marine protected areas now typically incorporates socioeconomic data to minimize potential negative impacts on stakeholders. However, these data have limitations that are not well understood. Furthermore, whether the application of socioeconomic data in planning actually reduces avoidable negative impacts on stakeholders is rarely evaluated.

This study assessed impacts on commercial fishermen of the rezoning of the Moreton Bay Marine Park, in south eastern Queensland. Specifically, this study (1) compared estimates of opportunity costs of new no-take zones from before and after the rezoning was implemented, and (2) identified impacts of the new zoning scheme on fishing businesses …

Outer Membrane Protein P5 Is Required For Resistance Of Nontypeable Haemophilus Influenzae To Both The Classical And Alternative Complement Pathways., Charles Rosadini, Sanjay Ram, Brian Akerley

Brian J. Akerley

No abstract provided.

Homeotic Gene Teashirt (Tsh) Has A Neuroprotective Function In Amyloid-Beta 42 Mediated Neurodegeneration., Michael M. Moran, Madhuri Kango-Singh, Amit Singh

Amit Singh

Background: Alzheimer's disease (AD) is a debilitating age related progressive neurodegenerative disorder characterized by the loss of cognition, and eventual death of the affected individual. One of the major causes of AD is the accumulation of Amyloid-beta 42 (Aβ42) polypeptides formed by the improper cleavage of amyloid precursor protein (APP) in the brain. These plaques disrupt normal cellular processes through oxidative stress and aberrant signaling resulting in the loss of synaptic activity and death of the neurons. However, the detailed genetic mechanism(s) responsible for this neurodegeneration still remain elusive. Methodology/ Principle Findings: We have generated a transgenic Drosophila eye model …

Microbial Synthesis Of Spherical Nanosilver And Nanogold For Mosquito Control, Soam Prakash, Namita Soni

Soam Prakash

Transitions, Risks, And Actions In Coronary Events--Center For Outcomes Research And Education (Trace-Core): Design And Rationale, Molly Waring, Richard Mcmanus, Jane Saczynski, Milena Anatchkova, David Mcmanus, Randolph Devereaux, Robert Goldberg, Jeroan Allison, Catarina Kiefe

Richard H. McManus

Background: Cardiovascular disease continues to cause significant morbidity, mortality, and impaired quality of life, with unrealized health gains from the underuse of available evidence. The Transitions, Risks, and Actions in Coronary Events Center for Outcomes Research and Education (TRACE-CORE) aims to advance the science of acute coronary syndromes by examining the determinants and outcomes of the quality of transition from hospital to community and by quantifying the impact of potentially modifiable characteristics associated with decreased quality of life, rehospitalization, and mortality. Methods and Results: TRACE-CORE comprises a longitudinal multiracial cohort of patients hospitalized with acute coronary syndromes, 2 research projects, …

Transitions, Risks, And Actions In Coronary Events--Center For Outcomes Research And Education (Trace-Core): Design And Rationale, Molly Waring, Richard Mcmanus, Jane Saczynski, Milena Anatchkova, David Mcmanus, Randolph Devereaux, Robert Goldberg, Jeroan Allison, Catarina Kiefe

Richard H. McManus

Background: Cardiovascular disease continues to cause significant morbidity, mortality, and impaired quality of life, with unrealized health gains from the underuse of available evidence. The Transitions, Risks, and Actions in Coronary Events Center for Outcomes Research and Education (TRACE-CORE) aims to advance the science of acute coronary syndromes by examining the determinants and outcomes of the quality of transition from hospital to community and by quantifying the impact of potentially modifiable characteristics associated with decreased quality of life, rehospitalization, and mortality. Methods and Results: TRACE-CORE comprises a longitudinal multiracial cohort of patients hospitalized with acute coronary syndromes, 2 research projects, …

Asiafurniture.Net Distributor Furniture Rotan Sintetis Dan Furniture Jepara Berkualitas.Pdf, Gembira Ria

gembiraria

Climate Change And Household Dynamics: Beyond Consumption, Unbounding Sustainability, Chris Gibson, Lesley Head, Nicholas Gill, Gordon Waitt

Chris Gibson

No abstract provided.

Nitmiluk: Place, Politics And Empowerment In Australian Aboriginal Popular Music, Chris Gibson, Peter Dunbar-Hall

Chris Gibson

No abstract provided.

Drunken Mobilities: Backpackers, Alcohol, 'Doing Place', Mark Jayne, Chris Gibson, Gordon Waitt, Gill Valentine

Chris Gibson

This article seeks to advance the understanding of the role of alcohol, drinking and drunkenness as an important, if under-researched, element of tourism. In so doing, we work at the intersection of three bodies of writing focused on mundane mobilities; performativities of tourism and geographies of alcohol, drinking and drunkenness. Drawing on empirical research undertaken in Australia, we highlight how alcohol, drinking and drunkenness are key to backpacking holidays: first, to help soften a number of (un)comfortable embodied and emotional materialities associated with budget travel; second, as an aid to spatial and temporal imperatives of ‘passing the time’ and ‘being …

Blue-Collar Creativity: Reframing Custom-Car Culture In The Imperilled Industrial City, Andrew Warren, Chris Gibson

Chris Gibson

This paper hitches a ride with young car enthusiasts to explore how their vehicles catalyse a unique form of vernacular creativity, in a seemingly imperilled industrial city setting.While television and print media regularly demonise young drivers for street racing and `hoon' behaviour, this paper purposely adopts a different perspective, on circuits of production and qualitative aspects of the urban custom-car design scene that constitute forms of vernacular creativity. Beyond moral panics little is known about movements, networks, and linkages between custom cars, young enthusiasts, and urban spaces from which their activities emerge. Utilising responsive, in-depth ethnographic methods in Wollongong, Australia, …

Gis, Ethnography, And Cultural Research: Putting Maps Back Into Ethnographic Mapping, Christopher Brennan-Horley, Susan Luckman, Christopher Gibson, Julie Willoughby-Smith

Chris Gibson

No abstract provided.

Geographic Information Technologies For Cultural Research: Cultural Mapping And The Prospects Of Colliding Epistemologies, Christopher Gibson, Christopher Brennan-Horley, Andrew Warren

Chris Gibson

No abstract provided.