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Full-Text Articles in Life Sciences
Focal Suppression Of Epileptiform Activity In The Hippocampus By A High-Frequency Magnetic Field, Hui Ye, Vincent Chiun-Fan Chen, Jessica Helon, Nicole Apostolopoulos
Focal Suppression Of Epileptiform Activity In The Hippocampus By A High-Frequency Magnetic Field, Hui Ye, Vincent Chiun-Fan Chen, Jessica Helon, Nicole Apostolopoulos
Biology: Faculty Publications and Other Works
Electric current has been used for epilepsy treatment by targeting specific neural circuitries. Despite its success, direct contact between the electrode and tissue could cause side effects including pain, inflammation, and adverse biological reactions. Magnetic stimulation overcomes these limitations by offering advantages over biocompatibility and operational feasibility. However, the underlying neurological mechanisms of its action are largely unknown. In this work, a magnetic generating system was assembled that included a miniature coil. The coil was positioned above the CA3 area of mouse hippocampal slices. Epileptiform activity (EFA) was induced with low Mg2+/high K+ perfusion or with 100 µM 4-aminopyridine (4-AP). …
Regulation Of Micrornas By 17Β-Estradiol In The Aging Female Brain, Yathindar Satya Giffin-Rao
Regulation Of Micrornas By 17Β-Estradiol In The Aging Female Brain, Yathindar Satya Giffin-Rao
Dissertations
Hormone Therapy (HT) is used to increase the 17β-estradiol (E2) levels in women who are going through the menopausal transition to alleviate the negative symptoms associated with menopause and decrease the risk of chronic diseases. Clinical and basic science research had previously shown that HT provided protection from cognitive decline and reduced the risk of dementia. However the Women's Health Initiative (WHI) clinical trial demonstrated that HT had no beneficial effects for cognitive decline and, in some cases increased the risk of dementia in post-menopausal women. However, further analysis of WHI data showed that when HT was given to women …
Estrogen Influences On The Developing Rat Hippocampus Through Interactions With The Brain Derived Neurotrophic Factor And P160 Coactivator Proteins, Derek Tyler Solum
Estrogen Influences On The Developing Rat Hippocampus Through Interactions With The Brain Derived Neurotrophic Factor And P160 Coactivator Proteins, Derek Tyler Solum
Dissertations
In addition to their primary role in the maintenance and regulation of reproductive capacity, ovarian steroid hormones acting through specific nuclear receptors influence more general neurobiological functions, such as perceptual-spatial skills and learning and memory. Estrogens act to alter certain aspects of cognitive performance and pathology such as epileptic seizure activity and Alzheimer’s disease. Furthermore, ovarian steroids act during development to alter the neuronal cytoarchitecture and synaptic connectivity. These early influences of steroids on the brain are essentially permanent and in part determine the steroid responsiveness of the adult brain. The mechanism and sites of action for the effects of …