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Prenatal Choline Supplementation And Mk-801 Toxicity: Protecting Memory And Preventing Neurodegeneration, Chelsea Nickerson
Prenatal Choline Supplementation And Mk-801 Toxicity: Protecting Memory And Preventing Neurodegeneration, Chelsea Nickerson
Honors Theses
Choline is essential to the development and function of the central nervous system. Supplemental choline is neuroprotective against a variety of insults, including neurotoxins like dizocilpine (MK-801). MK-801 is an NMDA receptor antagonist that is frequently used in rodent models of psychological disorders. At low doses, it causes cognitive impairments, and at higher doses it induces motor deficits, anhedonia, and neuronal degeneration. The primary goals of the present study were to investigate whether prenatal choline supplementation protects against the cognitive impairments, motor deficits, and neuropathologies that are precipitated by MK-801 administration in adulthood. Adult male Sprague Dawley rats were fed …