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Full-Text Articles in Life Sciences
Molecular Mechanisms Of Stress-Induced Increases In Fear Memory Consolidation Within The Amygdala, Antonio V. Aubry, Peter A. Serrano, Nesha S. Burghardt
Molecular Mechanisms Of Stress-Induced Increases In Fear Memory Consolidation Within The Amygdala, Antonio V. Aubry, Peter A. Serrano, Nesha S. Burghardt
Publications and Research
Stress can significantly impact brain function and increase the risk for developing various psychiatric disorders. Many of the brain regions that are implicated in psychiatric disorders and are vulnerable to the effects of stress are also involved in mediating emotional learning. Emotional learning has been a subject of intense investigation for the past 30 years, with the vast majority of studies focusing on the amygdala and its role in associative fear learning. However, the mechanisms by which stress affects the amygdala and amygdala-dependent fear memories remain unclear. Here we review the literature on the enhancing effects of acute and chronic …
Social Defeat Stress Induces Depression-Like Behavior And Alters Spine Morphology In The Hippocampus Of Adolescent Male C57bl/6 Mice, Sergio D. Iñiguez, Antonio Aubry, Lace M. Riggs, Jason B. Alipio, Roseanna M. Zanca, Francisco J. Flores-Ramirez, Mirella A. Hernandez, Steven J. Nieto, David Musheyev, Peter Serrano
Social Defeat Stress Induces Depression-Like Behavior And Alters Spine Morphology In The Hippocampus Of Adolescent Male C57bl/6 Mice, Sergio D. Iñiguez, Antonio Aubry, Lace M. Riggs, Jason B. Alipio, Roseanna M. Zanca, Francisco J. Flores-Ramirez, Mirella A. Hernandez, Steven J. Nieto, David Musheyev, Peter Serrano
Publications and Research
Social stress, including bullying during adolescence, is a risk factor for common psychopathologies such as depression. To investigate the neural mechanisms associated with juvenile social stress-induced mood-related endophenotypes, we examined the behavioral, morphological, and biochemical effects of the social defeat stress model of depression on hippocampal dendritic spines within the CA1 stratum radiatum. Adolescent (postnatal day 35) male C57BL/6 mice were subjected to defeat episodes for 10 consecutive days. Twenty-four h later, separate groups of mice were tested on the social interaction and tail suspension tests. Hippocampi were then dissected and Western blots were conducted to quantify protein levels for …