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Articles 1 - 11 of 11

Full-Text Articles in Life Sciences

Chytrid Loads, Pathogen Prevalence, And Contemporary Host Source-Sink Dynamics In Dry Vs. Wet Forests; Evaluating Refugia From Disease In Australian Torrent Frogs., Barbara Rizzo Jan 2014

Chytrid Loads, Pathogen Prevalence, And Contemporary Host Source-Sink Dynamics In Dry Vs. Wet Forests; Evaluating Refugia From Disease In Australian Torrent Frogs., Barbara Rizzo

Dissertations and Theses

No abstract provided.


The Impact Of Saccadic Eye Movement Training On Saccade Accuracy And Latency, Stephanie Montenegro Jan 2014

The Impact Of Saccadic Eye Movement Training On Saccade Accuracy And Latency, Stephanie Montenegro

Dissertations and Theses

No abstract provided.


Kos Modulation Of Mitochondrial Fission And Fusion, Herman Kucharavy Jan 2014

Kos Modulation Of Mitochondrial Fission And Fusion, Herman Kucharavy

Dissertations and Theses

No abstract provided.


Structure-Function Analysis Of Zapc, An Ftsz-Ring Stabilizer, In Escherichia Coli Cytokinesis, Lukasz Tchorzewski Jan 2014

Structure-Function Analysis Of Zapc, An Ftsz-Ring Stabilizer, In Escherichia Coli Cytokinesis, Lukasz Tchorzewski

Dissertations and Theses

In Escherichia coli, cell division is defined by the polymerization and constriction of a cytokinetic ring (Z ring) formed by FtsZ, a tubulin-like GTPase, at midcell. Division also involves the formation of a multi-protein complex at midcell known as the divisome. Several divisome proteins promote the assembly/disassembly processes of FtsZ, thereby exercising spatiotemporal control over division. Among FtsZ regulatory proteins are the FtsZ ringassociated proteins (Zap), which either directly or indirectly stabilize the Z-ring by increasing lateral interactions amongst FtsZ protofilaments in the Z-ring. ZapA-D are recruited during early cytokinesis and have overlapping functions in stabilizing FtsZ at midcell, but …


Investigating Innate Immune Signaling Cross-Talk In A Drosophila Tumor-Inflammation Model, Rebecca Moore Jan 2014

Investigating Innate Immune Signaling Cross-Talk In A Drosophila Tumor-Inflammation Model, Rebecca Moore

Dissertations and Theses

No abstract provided.


Methodological Advancements For Improving Performance And Generating Ensemble Ecological Niche Models, Robert Boria Jan 2014

Methodological Advancements For Improving Performance And Generating Ensemble Ecological Niche Models, Robert Boria

Dissertations and Theses

This study employs spatial filtering of occurrence data with the aim of reducing overfitting to sampling bias in ecological niche models (ENMs). Sampling bias in geographic space leads to localities that may also be biased in environmental space. If so, the model can overfit to those biases. As a preliminary test addressing this issue, we used Maxent, bioclimatic variables, and occurrence localities of a broadly distributed Malagasy tenrec, Microgale cowani (Family Tenrecidae: Subfamily Oryzorictinae). We modeled the abiotically suitable area of this species using three distinct datasets: unfiltered, spatially filtered, and rarefied unfiltered localities. To quantify overfitting and model performance, …


Screen For Suppressors And Enhancers Of Excitotoxic Neurodegeneration, Anthony Omorodion Edokpolo Jan 2014

Screen For Suppressors And Enhancers Of Excitotoxic Neurodegeneration, Anthony Omorodion Edokpolo

Dissertations and Theses

Excitotoxicity is an important and frequently observed neurodegenerative process. Excitotoxicity mediates brain damage in a range of diseases and conditions including stroke, and is triggered by excessive stimulation of glutamatergic synapses. In spite of extensive studies, the molecular mechanisms involved in excitotoxicity following the over-activation of postsynaptic glutamate receptors are not well understood, and clinical trials based on our partial understanding of the process ended with disappointment. Genetic screens in simple animal models offer a powerful alternative approach, since screens are unbiased, analysis is facilitated by strong research tools, and cellular mechanisms are highly conserved through evolution. We produced a …


Caffeine's Attenuation Of Cocaine-Induced Deficiency In Acoustic Startle Response By Inhibition Of Adenosine In A Sex And Dose Dependent Manner, Lauren B. Malave Jan 2014

Caffeine's Attenuation Of Cocaine-Induced Deficiency In Acoustic Startle Response By Inhibition Of Adenosine In A Sex And Dose Dependent Manner, Lauren B. Malave

Dissertations and Theses

No abstract provided.


Synaptic Physiology Of Glutamate Clearance In The Nematode Caenorhabditis Elegans, Jenny (Chan Ying) Wong Jan 2014

Synaptic Physiology Of Glutamate Clearance In The Nematode Caenorhabditis Elegans, Jenny (Chan Ying) Wong

Dissertations and Theses

No abstract provided.


A Phylogeographic Study Of Two Neotropical Bird Species, The Red-Headed Manakin (Pipna Rubrocapilla) And The White-Crowned Manakin (Dixiphia Pipra)., Ivandy Castro-Astor Jan 2014

A Phylogeographic Study Of Two Neotropical Bird Species, The Red-Headed Manakin (Pipna Rubrocapilla) And The White-Crowned Manakin (Dixiphia Pipra)., Ivandy Castro-Astor

Dissertations and Theses

No abstract provided.


Experimental Studies Of Rctb- Initiator Of Vibrio Cholerae Chromosome Ii Replication: Genetic Engineering, Protein Purification, And Protein Crystals, Olha Ivashkiv Jan 2014

Experimental Studies Of Rctb- Initiator Of Vibrio Cholerae Chromosome Ii Replication: Genetic Engineering, Protein Purification, And Protein Crystals, Olha Ivashkiv

Dissertations and Theses

Vibrio cholerae, a member of the Vibrionaceae family, is notorious as the causative agent of acute gastrointestinal disease known as cholera. Genetic information in members of the Vibrionaceae family is distributed between two chromosomes that are distinctively maintained. In V. cholerae, the initiation of DNA replication in each chromosome involves distinct processes. While the initiation of replication of chromosome I is carried by DnaA, the initiation of chromosome II replication is controlled by RctB, a DNA-binding protein that is an exclusive attribute of all Vibrio species. RctB has no homologs among other members of bacteria proteins and can serve as …