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Full-Text Articles in Life Sciences
Suppressor Of Cytokine Signaling-3 In Pregnant Females With Or Without Hypertension, Huma Shoukat Ali, Mubeen Ali, Sabah Farhat, Syeda Sadia Fatima
Suppressor Of Cytokine Signaling-3 In Pregnant Females With Or Without Hypertension, Huma Shoukat Ali, Mubeen Ali, Sabah Farhat, Syeda Sadia Fatima
Department of Biological & Biomedical Sciences
Suppression of Cytokine Signalling-3 (SOCS-3) modulates the inflammatory pathways responsible for vascular stability. Therefore, we aimed to estimate SOCS-3 levels in 2nd trimester pregnant females and correlate it with blood pressure. A case control study recruiting (n=111) females was conducted at the Aga Khan University. They were classified as pregnancy induced hypertensives ornormotensive as per American College of Obstetricians and Gynecologists Guidelines. Weight, Body mass index, lipid profile and blood glucose were recorded while SOCS-3 was measured by ELISA. Higher SOCS-3 levels were seen in hypertensive group (30 pg/ml) versus normotensive (16 pg/ml). Both Systolic & diastolic blood pressure (r=0.520; …
Evaluation Of Soluble Tnf-Like Weak Inducer Of Apoptosis (Stweak) Levels To Predict Preeclampsia In Early Weeks Of Pregnancy, Sana Shahid, Erum Khalid, Syeda Sadia Fatima, Ghulam Mustafa Khan
Evaluation Of Soluble Tnf-Like Weak Inducer Of Apoptosis (Stweak) Levels To Predict Preeclampsia In Early Weeks Of Pregnancy, Sana Shahid, Erum Khalid, Syeda Sadia Fatima, Ghulam Mustafa Khan
Department of Biological & Biomedical Sciences
Introduction: Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) is linked to endothelial dysfunction; a key factor in pre-eclamptic pathogenesis. This study aimed to compare sTWEAK levels during pregnancy to assess for its prognostic ability.
Materials and Methods: Sixty three high risk pregnant women were followed up from 12 weeks of gestation till term. Serum levels of sTWEAK and platelet derived growth factor (PlGF), blood pressure, serum glucose, uric acid, urea/creatinine and liver function tests were measured. Subjects were stratified according to the ACOG criteria as women who developed PE, or PIH or remained normotensive at term. A negative …
Gestational Diabetes Mellitus And The Predisposing Factors, Syeda Sadia Fatima, Rehana Rehman, Faiza Alam, Sarosh Madhani, Bushra Chaudhry, Taseer Ahmed Khan
Gestational Diabetes Mellitus And The Predisposing Factors, Syeda Sadia Fatima, Rehana Rehman, Faiza Alam, Sarosh Madhani, Bushra Chaudhry, Taseer Ahmed Khan
Department of Biological & Biomedical Sciences
Objective: To evaluate the occurrence of gestational diabetes mellitus and its association with demographic and anthropometric variables in pregnant women.
Methods: This cross-sectional study was conducted at the Aga Khan University Hospital, Abbasi Shaheed Hospital and Memon Hospital in Karachi, from February 2014 to December 2015, and comprised pregnant women who were screened by 75-g 2-hour oral glucose tolerance test, (24-28 weeks of gestation) and classified as per the criteria of the International Association of Diabetes and Pregnancy Study Group. Weight, body mass index and serum glycated haemoglobin levels were measured. Women with pre-gestational diabetes were excluded. SPSS 21 was …
Blood Lead Levels During Pregnancy And Pregnancy Outcome In Karachi Women, A Rahman, A Hakeem
Blood Lead Levels During Pregnancy And Pregnancy Outcome In Karachi Women, A Rahman, A Hakeem
Department of Biological & Biomedical Sciences
objective: To evaluate association of blood lead levels with pregnancy outcome in the obstetrics and gynaecology unit.
Methods: Blood lead levels were measured in 73 pregnant women at the time of delivery and assessed its association with pregnancyoutcome.
Results: Mean maternal lead level was 9.91+/-4.44 mg/dL (range 2.28-36.35 mg/dL). Mothers of boys had significantly higher (p=0.013, one-tailed t test) blood lead levels (11.05+/-5.19) when compared to mothers of girls (8.74+/-3.18 mg/dL.
Conclusion: Maternal lead levels at the time of delivery showed no association with gestational age, birth weight, recumbent length, or head circumference.