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Effect Of Metformin On Mir-146a Expression, S. Jackson Grout, Bryce C. Macturk, Amanda D. Sims, Kaleb M. Pauley
Effect Of Metformin On Mir-146a Expression, S. Jackson Grout, Bryce C. Macturk, Amanda D. Sims, Kaleb M. Pauley
The Research and Scholarship Symposium (2013-2019)
Sjögren’s Syndrome (SjS) is an autoimmune disorder that affects secretory glands in the human body, restricting their function and causing extreme dryness in areas like the mouth and eyes. miR-146a is an anti-inflammatory microRNA that targets the NFκB activation pathway. Previous studies have shown that SjS patients have increased miR-146a expression, despite having high levels of inflammation. The objective of this study was to investigate whether metformin, a diabetes drug with a wide variety of effects and potential functions, reduces levels of miR-146a expression. Metformin is known to reduce inflammation by inhibiting the activation of NFκB. THP-1 human monocytes were …