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The Apoptotic Effect Of 1 ' S-1 '-Acetoxychavicol Acetate From Alpinia Conchigera On Human Cancer Cells, Halijah Ibrahim, Aziz A. N., Nagoor N. H., Awang K., Azmi M. N., Aun L. I. L.
The Apoptotic Effect Of 1 ' S-1 '-Acetoxychavicol Acetate From Alpinia Conchigera On Human Cancer Cells, Halijah Ibrahim, Aziz A. N., Nagoor N. H., Awang K., Azmi M. N., Aun L. I. L.
Halijah Ibrahim
1'-(S)-1'-Acetoxychavicol acetate (ACA) isolated from the Malaysian ethno-medicinal plant Alpinia conchigera Griff. was investigated for its potential as an anticancer drug. In this communication, we describe the cytotoxic and apoptotic properties of ACA on five human tumour cell lines. Data from MTT cell viability assays indicated that ACA induced both time- and dose-dependent cytotoxicity on all tumour cell lines tested and had no adverse cytotoxic effects on normal cells. Total mortality of the entire tumour cell population was achieved within 30 hrs when treated with ACA at 40.0 microM concentration. Flow cytometric analysis for annexin-V and PI dual staining demonstrated …