Life Sciences Commons^™

Hepatotoxic Effect Of Cadmium And Available Therapeutic Options, Tomilola Olaolu, Favour Jibulu, Rotimi Damilare

The Thai Journal of Pharmaceutical Sciences

Hepatoxicity, also known as toxic hepatitis, is a condition, in which the liver becomes inflamed due to exposure to such substances as chemicals, medications, herbal products, or excessive alcohol consumption. Cadmium is a major environmental pollutant from agricultural and industrial sources and has been reported to induce hepatotoxicity. Cadmium can also be found in phosphate fertilizers, detergents, and refined petroleum products as an impurity and used industrially in the production of polyvinyl chloride product stabilizers and the fabrication of nickel-cadmium batteries. Cadmium can be absorbed into the human body through the gastrointestinal tract, respiratory, and dermal routes. Cadmium-induced hepatic damage …

Behavioral Alterations Following Exposure To A Mixture Of Lead And Atrazine During Early Development In The Zebrafish Model System, Anusha Kv Lakshmi Dharmavathi

The Journal of Purdue Undergraduate Research

Lead (Pb) and atrazine (ATZ) are hazardous environmental toxicants that can exist as a mixture in potable water. Numerous single chemical studies on Pb and ATZ support adverse health outcomes, including neurotoxicity, but mixture studies are limited. Th e aim of this study is to test the hypothesis that Pb and ATZ mixtures result in a greater than additive toxicity, causing increased adverse health outcomes than single chemical exposures. Th e zebrafish model system was exposed to 3 or 30 ppb (µg/L) ATZ, 10 ppb (equivalent to 0.1 µg/dL) or 100 ppb Pb, along with mixtures of each beginning at …

Fruits Of Nandina Domestica Are (Sometimes) Cyanogenic And (Sometimes) Hazardous To Birds, Scott Zona

Poisonous Plant Research (PPR)

A 12-month survey of cyanogenesis in the fruits and leaves of Nandina domestica (Berberidaceae) revealed that the leaves are strongly cyanogenic throughout the year, as measured by the Feigl-Anger test. Fruits vary in their cyanogenic potential depending on the degree of ripeness and clone. Green fruits are strongly and rapidly cyanogenic, but most ripe fruits are weakly and slowly cyanogenic. Some fruits tested negative for cyanide. Fruits tend to become less cyanogenic the longer they remain on the plant, so birds feeding on older fruits are at a lower risk of poisoning. More than other frugivores, cedar waxwings (Bombycilla …

Virgin Coconut Oil Ameliorates Arsenic Hepatorenal Toxicity And No-Mediated Inflammation Through Suppression Of Oxidative Stress In Rats, Ademola C. Famurewa, Ekenechukwu K. Maduagwuna, Chinyere Aloke, Sharon O. Azubuike-Osu, Arunaksharan Narayanankutty

The Thai Journal of Pharmaceutical Sciences

Background: Compelling evidence has implicated oxidative stress as a leading mechanism for arsenic (As)-induced pathologies. We evaluated antioxidant effect of virgin coconut oil (VCO) against arsenic-induced oxidative stress-mediated hepatorenal damage in rats. Methods: Rats were randomly divided into three groups: Control group, as group, and VCO + As group. VCO was orally administered before and along with arsenic (10 mg/kg body weight, orally) for 21 days. Subsequently, serum liver enzymes, albumin (ALB), creatinine, urea, antioxidant enzymes, malondialdehyde, and nitric oxide (NO) level were evaluated. The histology of the tissues was analyzed with standard procedures. Results: Arsenic caused marked increases in …

Evaluation Of Acute Oral Toxicity Of Methanolic Fractions Of Sesbania Grandiflora Linn. Roots In Albino Mice, N. S. Vinay, S. Babitha, R. Nandeesh, S. Paramesh, E. Manjunath, J. P. Geetha, V. P. Veerapur, B. Swetha, H. V. Keerthi Prasanth

The Thai Journal of Pharmaceutical Sciences

Introduction: Although Sesbania grandiflora Linn. roots have valuable pharmacological effects, the comprehensive awareness about its toxicity potential has been lacking. Objectives: The objectives of the study were to assess the acute oral toxicity of methanolic fraction of S. grandiflora root (MFSGR). Materials and Methods: The female albino mice were divided into two groups (n = 5), one group served as normal control while the other treated with MFSGR (2000 mg/kg, p.o). Both the groups of mice were observed for 14 days for various parameters according to the Organization for Economic Cooperative and Development guidelines 425 TG. Results: Oral administration of …

The Influence Of Acidification And Copper Exposure On Copper Accumulation And Anti-Oxidant Enzyme Responses In The Pond Snail, Lymnaea Stagnalis, Gretchen K. Bielmyer-Fraser, Francis Alip, Ruth Adeyemi, Nolan Carney, Fasinia Santiago, Kyla Siemen, Kiley Donaghy

Georgia Journal of Science

Atmospheric carbon dioxide is rising at an accelerated rated due to increased anthropogenic activities. Metals have also been a noted problem; however, little research has addressed combined exposure of both pollutants to sensitive, calcifying organisms in freshwater habitats. This study examined copper accumulation (over 7 d) and activity of the antioxidant enzymes, catalase and glutathione peroxidase (over 2 d), in the freshwater common pond snail, Lymnaea stagnalis, after exposure to ambient and increased (2000 µatm) CO₂ and copper (control, 5, and 20 µg/L). Results demonstrated increased copper accumulation in soft tissue of snails exposed to copper; however, exposure to …

Is Pnc-27 And Pnc-28 The Best Way To Cure Cancer?, Miriam Silberstein

The Science Journal of the Lander College of Arts and Sciences

Immunotherapeutic agents have been researched for many decades as an alternative treatment for cancer. Current research demonstrates that immunotherapy is safer than radiotherapy or chemotherapy. This is attributed to immunotherapy’s mechanism of utilizing the body’s own defense system, as opposed to absorbing harmful chemicals. Two forms of immunotherapy that have been effective in curing cancer without the added danger of chemical toxicity are PNC-27 and PNC-28. These peptides were created by a supercomputer at SUNY Downstate Medical Center in New York in 2000. PNC-27 and PNC-28 work with the MDM2 -P53 tumor suppressor complex. It acts as a competitive inhibitor …

Influence Of Water Hardness On Accumulation And Effects Of Silver In The Green Alga, Raphidocelis Subcapitata, Aarya Venkat, Adriana L. Amerson, Gretchen K. Bielmyer-Fraser

Georgia Journal of Science

Metal pollution from anthropogenic sources can pose a threat to aquatic systems. Silver is released into the environment from various industrial processes. In excess, silver can accumulate and cause adverse effects in aquatic organisms, particularly those in lower trophic levels, such as phytoplankton. Water chemistry parameters, such as hardness, have been shown to modify toxicity of metals because divalent cations compete with the metal for binding sites on the biological membrane. The objective of this study was to assess population growth and silver accumulation in the green alga, Raphidocelis subcapitata, after silver exposure in waters of varying hardness for 7 …

Toxicity Of Traditional Medicine Trisan. Part 2. Vata And Semha Formulas(พิษของยาแผนโบราณตรีสาร ตอนที่ 2 ตำรับวาตะและเสมหะสมุฏฐาน), Pranee Chavalittumrong, Aimmanas Attawish, Pat Rugsamon, Pranee Chuntapet

The Thai Journal of Pharmaceutical Sciences

Trisan, a Thai traditional medicine, is composed of three constituents, namely Plumbago indica, Piper sarmentosum and Piper sp. locally called Sa-Karn, at different ratios based on traditional diagnosis of patients. Vata formula of Trisan, used for the e...

Toxicity Of Andrographis Paniculata Wall, Ex Nees(พิษเฉียบพลันและกึ่งเรื้อรังของฟ้าทะลายโจร), นาถฤดี สิทธิสมวงศ์, เจษฎา เพ็งชะตา, ทรงพล ชีวะพัฒน์, เอมมนัส หวังหมัด, พัชรินทร์ รักษามั่น, จรินทร์ จันทรฉายะ, ปรียา สุวรรณคีรี

The Thai Journal of Pharmaceutical Sciences

Acute toxicity test of 50% alcoholic extract of Andrographis paniculata Wall, ex Nees. revealed no evidence of toxicity in mice when given 15 gm/kg body weight. LD50 of the extract administered per os and subcutaneous are more than 15 gm/kg and intraperi...

Cotton Fireweed : Potential Poison : Research Roundup, J Dickson, R. Hill

Journal of the Department of Agriculture, Western Australia, Series 4

Although long known as a potential toxic species because of its content, and although it is widely distribuited in all Australian States, cotton fireweed has not generally been consdidered toxic because it is unpalatable and not usually eaten by stock.

In 1973 cattle deaths occured near Ravensthorpe which led to research into Senecio quadridentatus (cotton fireweed).

The plant must be seen as a potential toxic species in situations where the lack of other feed forces cattle to eat the normally unpalatable cotton fireweed.

Effect On Bees Of Insecticides Used On Rape, A C. Kessell

Journal of the Department of Agriculture, Western Australia, Series 4

Rapeseed could provide beekeepers in Western Australia with a valuable new honey crop—hut insecticidal spraying of rape at flowering time is a potentially serious threat to most commercial beekeepers.

There are indications that insect pollination may improve rapeseed yields, so both growers and beekeepers could gain from a co-operative approach to the problem. Spraying after sundown and preventing spray drift to nearby apiaries should avoid most losses.

Poison Sedge Can Kill Stock, M E. Nairn, T. E. H. Aplin, D. S. Petterson, A. J. Brighton

Journal of the Department of Agriculture, Western Australia, Series 4

POISON SEDGE was first suspected of being toxic to livestock in Western Australia nearly 80 years ago.

Sudden deaths of sheep grazing areas on which poison sedge grew have been reported from many regions from Geraldton to Scott River.

This article reports a case of poisoning in the field, and the experimental reproduction of poison sedge toxicity in pen-fed sheep.

Poultry : Toxic Factors In Protein Supplements, D F. Hessels

Journal of the Department of Agriculture, Western Australia, Series 4

The toxic effect of low quality and/or stale protein supplements can be a problem in the poultry industry.

This article describes trials carried out to assess their importance in Western Australia.

Chemical Poisoning In Animals. 1. Arsenic, H D. Seddon

Journal of the Department of Agriculture, Western Australia, Series 4

ARSENIC is poisonous to all animals and to man in quite small amounts and exposure to poisoning is often a result of human carelessness.

It is present in many chemical dips used for control of insect parasites on stock, and in agricultural fruit sprays and weed killers whose relative cheapness makes their use economical.

However, their potential danger and the economic loss they may cause are a disadvantage.

Bracken Poisoning In Cattle, P B. Lewis

Journal of the Department of Agriculture, Western Australia, Series 4

THE ingestion of bracken fern causes the death of numbers of young cattle in the South-West of Western Australia every year.

Early experimental work in the United Kingdom demonstrated that bracken contained an anti-Vitamin Bl factor called thiaminase which was thought to be the cause of the poisoning, but later work indicated that a bone marrow poisoning, not yet chemically identified, was responsible.

Zamia Palm Poisoning, F C. Wilkinson

Journal of the Department of Agriculture, Western Australia, Series 4

THE Zamia palm (Macrozamia Reidlei) is a common plant in the jarrah and karri forest country and on the coastal plains and is one of the earliest recorded Australian poison plants.

Lupinosis, H W. Bennetts

Journal of the Department of Agriculture, Western Australia, Series 4

LUPINOSIS is a disease which has caused severe mortalities in West Australian sheep flocks in recent years, and one which—because of the important role which lupins are playing in light land development—must inevitably continue to be a matter of serious concern.