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Full-Text Articles in Life Sciences
The Skp1 Homologs Skr-1/2 Are Required For The Caenorhabditis Elegans Skn-1 Antioxidant/Detoxification Response Independently Of P38 Mapk., Cheng-Wei Wu, Andrew Deonarine, Aaron Przybysz, Kevin Strange, Keith P. Chloe
The Skp1 Homologs Skr-1/2 Are Required For The Caenorhabditis Elegans Skn-1 Antioxidant/Detoxification Response Independently Of P38 Mapk., Cheng-Wei Wu, Andrew Deonarine, Aaron Przybysz, Kevin Strange, Keith P. Chloe
Molecular Biosciences Faculty Publications
SKN-1/Nrf are the primary antioxidant/detoxification response transcription factors in animals and they promote health and longevity in many contexts. SKN-1/Nrf are activated by a remarkably broad-range of natural and synthetic compounds and physiological conditions. Defining the signaling mechanisms that regulate SKN-1/Nrf activation provides insights into how cells coordinate responses to stress. Nrf2 in mammals is regulated in part by the redox sensor repressor protein named Keap1. In C. elegans, the p38 MAPK cascade in the intestine activates SKN-1 during oxidative stress by promoting its nuclear accumulation. Interestingly, we find variation in the kinetics of p38 MAPK activation and tissues with …
Hearing In The Juvenile Green Sea Turtle (Chelonia Mydas): A Comparison Of Underwater And Aerial Hearing Using Auditory Evoked Potentials, Wendy E D Piniak, David A Mann, Craig A Harms, T Todd Jones, Scott A Eckert
Hearing In The Juvenile Green Sea Turtle (Chelonia Mydas): A Comparison Of Underwater And Aerial Hearing Using Auditory Evoked Potentials, Wendy E D Piniak, David A Mann, Craig A Harms, T Todd Jones, Scott A Eckert
Marine Science Faculty Publications
Sea turtles spend much of their life in aquatic environments, but critical portions of their life cycle, such as nesting and hatching, occur in terrestrial environments, suggesting that it may be important for them to detect sounds in both air and water. In this study we compared underwater and aerial hearing sensitivities in five juvenile green sea turtles (Chelonia mydas) by measuring auditory evoked potential responses to tone pip stimuli. Green sea turtles detected acoustic stimuli in both media, responding to underwater stimuli between 50 and 1600 Hz and aerial stimuli between 50 and 800 Hz, with maximum sensitivity between …
Gut Immunity In A Protochordate Involves A Secreted Immunoglobulin-Type Mediator Binding Host Chitin And Bacteria, Larry J. Dishaw, Brittany Leigh, John P. Cannon, Assunta Liberti, M. Gail Mueller, Diana P. Skapura, Charlotte R. Karrer, Maria R. Pinto, Rosaria De Santis, Gary W. Litman
Gut Immunity In A Protochordate Involves A Secreted Immunoglobulin-Type Mediator Binding Host Chitin And Bacteria, Larry J. Dishaw, Brittany Leigh, John P. Cannon, Assunta Liberti, M. Gail Mueller, Diana P. Skapura, Charlotte R. Karrer, Maria R. Pinto, Rosaria De Santis, Gary W. Litman
Marine Science Faculty Publications
Protochordate variable region-containing chitin-binding proteins (VCBPs) consist of immunoglobulin-type V domains and a chitin-binding domain (CBD). VCBP V domains facilitate phagocytosis of bacteria by granulocytic amoebocytes; the function of the CBD is not understood. Here we show that the gut mucosa of Ciona intestinalis contains an extensive matrix of chitin fibrils to which VCBPs bind early in gut development, before feeding. Later in development, VCBPs and bacteria colocalize to chitin-rich mucus along the intestinal wall. VCBP-C influences biofilm formation in vitro and, collectively, the findings of this study suggest that VCBP-C may influence the overall settlement and colonization of bacteria …
Begomovirus-Associated Satellite Dna Diversity Captured Through Vector-Enabled Metagenomic (Vem) Surveys Using Whiteflies (Aleyrodidae), Karyna Rosario, Christian Marr, Arvind Varsani, Simona Kraberger, Daisy Stainton, Enrique Moriones, Jane E Polston, Mya Breitbart
Begomovirus-Associated Satellite Dna Diversity Captured Through Vector-Enabled Metagenomic (Vem) Surveys Using Whiteflies (Aleyrodidae), Karyna Rosario, Christian Marr, Arvind Varsani, Simona Kraberger, Daisy Stainton, Enrique Moriones, Jane E Polston, Mya Breitbart
Marine Science Faculty Publications
Monopartite begomoviruses (Geminiviridae), which are whitefly-transmitted single-stranded DNA viruses known for causing devastating crop diseases, are often associated with satellite DNAs. Since begomovirus acquisition or exchange of satellite DNAs may lead to adaptation to new plant hosts and emergence of new disease complexes, it is important to investigate the diversity and distribution of these molecules. This study reports begomovirus-associated satellite DNAs identified during a vector-enabled metagenomic (VEM) survey of begomoviruses using whiteflies collected in various locations (California (USA), Guatemala, Israel, Puerto Rico, and Spain). Protein-encoding satellite DNAs, including alphasatellites and betasatellites, were identified in Israel, Puerto Rico, and Guatemala. Novel …
How The Bending Kinematics Of Swimming Lampreys Build Negative Pressure Fields For Suction Thrust, Brad J. Gemmell, Stephanie M. Fogerson, John H. Costello, Jennifer R. Morgan, John O. Dabiri, Sean P. Colin
How The Bending Kinematics Of Swimming Lampreys Build Negative Pressure Fields For Suction Thrust, Brad J. Gemmell, Stephanie M. Fogerson, John H. Costello, Jennifer R. Morgan, John O. Dabiri, Sean P. Colin
Integrative Biology Faculty and Staff Publications
Swimming animals commonly bend their bodies to generate thrust. For undulating animals such as eels and lampreys, their bodies bend in the form of waves that travel from head to tail. These kinematics accelerate the flow of adjacent fluids, which alters the pressure field in a manner that generates thrust. We used a comparative approach to evaluate the cause-and-effect relationships in this process by quantifying the hydrodynamic effects of body kinematics at the body-fluid interface of the lamprey, Petromyzon marinus, during steady-state swimming. We compared the kinematics and hydrodynamics of healthy control lampreys to lampreys whose spinal cord had been …