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Full-Text Articles in Life Sciences
Copper Oxide Nanoparticles Impact Several Toxicological Endpoints And Cause Neurodegeneration In Caenorhabditis Elegans, Michael Joseph Mashock, Tyler Zanon, Anthony D. Kappell, Lisa N. Petrella, Erik C. Andersen, Krassimira R. Hristova
Copper Oxide Nanoparticles Impact Several Toxicological Endpoints And Cause Neurodegeneration In Caenorhabditis Elegans, Michael Joseph Mashock, Tyler Zanon, Anthony D. Kappell, Lisa N. Petrella, Erik C. Andersen, Krassimira R. Hristova
Biological Sciences Faculty Research and Publications
Engineered nanoparticles are becoming increasingly incorporated into technology and consumer products. In 2014, over 300 tons of copper oxide nanoparticles were manufactured in the United States. The increased production of nanoparticles raises concerns regarding the potential introduction into the environment or human exposure. Copper oxide nanoparticles commonly release copper ions into solutions, which contribute to their toxicity. We quantified the inhibitory effects of both copper oxide nanoparticles and copper sulfate on C. elegans toxicological endpoints to elucidate their biological effects. Several toxicological endpoints were analyzed in C. elegans, including nematode reproduction, feeding behavior, and average body length. We examined three …