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Full-Text Articles in Life Sciences
Identification Of Kinase Signaling Pathways Inducing Morphological Changes In Dendritic Cells Upon Leptin Treatment, Marisol Ann O'Neill
Identification Of Kinase Signaling Pathways Inducing Morphological Changes In Dendritic Cells Upon Leptin Treatment, Marisol Ann O'Neill
Open Access Theses & Dissertations
Leptin is a pleiotropic hormone secreted by white adipose tissue. Obesity leads to overexpression of leptin as a result of leptin receptor desensitization. Obese leptin serum levels (160ng/ml) have been found to enhance immune functions in macrophages, natural killer cells, B cells, T cells, and dendritic cells. Previous data from our lab suggests that obese concentrations of leptin cause morphological changes in DCs, although further studies are required to verify these results. We hypothesized that leptin promotes DC cytoskeletal changes though activation of PI3K signaling. Morphological and functional changes were evaluated in JAWS II immortalized DCs though microscopy, transwell migration, …
The Effect Of Exogenous Leptin On Dendritic Cell Migration And Interactions With T Cells, Amanda L. Gonzales
The Effect Of Exogenous Leptin On Dendritic Cell Migration And Interactions With T Cells, Amanda L. Gonzales
Open Access Theses & Dissertations
Obesity is a complex, chronic disease that has reached epidemic proportions in the United States and shows no indication of receding. It is a state of chronic low-grade inflammation that is initiated by morphological changes in large accumulations of adipose tissue. Leptin is a pleiotropic hormone secreted by adipose tissue, presenting a possible link between obesity and inflammation. In this study, we assessed the effect of leptin on bone marrow-derived (BM) dendritic cells (DC) (BM-DC) function, antigen presenting cells vital for the activation of naí¯ve T cells. Previous data produced in our laboratory established that the addition of leptin to …
Altered Leptin Signaling On Dendritic Cells As A Potential Mechanism For Cancer Immunotherapy, Lorena Y. De Los Santos
Altered Leptin Signaling On Dendritic Cells As A Potential Mechanism For Cancer Immunotherapy, Lorena Y. De Los Santos
Open Access Theses & Dissertations
Leptin is a pleiotropic hormone synthesized primarily by white adipocytes and its receptors are expressed in a variety of tissues and cells such as in the hypothalamus and cells of the immune system. Multiple cell types can produce a considerable amount of leptin such as skeletal muscle, placenta, and osteoblasts to name a few and its synthesis has been shown to be regulated by sex hormones and a broad range of inflammatory mediators. Although leptin has been shown to directly affect immune response, we are interested in how leptin affects dendritic cell function and their ability to induce a proper …