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Cloning Of The Neurodegeneration Gene Drop-Dead And Characterization Of Additional Phenotypes Of Its Mutation, Edward M. Blumenthal
Cloning Of The Neurodegeneration Gene Drop-Dead And Characterization Of Additional Phenotypes Of Its Mutation, Edward M. Blumenthal
Biological Sciences Faculty Research and Publications
Mutations in the Drosophila gene drop-dead (drd) result in early adult lethality and neurodegeneration, but the molecular identity of the drd gene and its mechanism of action are not known. This paper describes the characterization of a new X-linked recessive adult-lethal mutation, originally called lot's wife (lwf1) but subsequently identified as an allele of drd (drdlwf); drdlwf mutants die within two weeks of eclosion. Through mapping and complementation, the drd gene has been identified as CG33968, which encodes a putative integral membrane protein of unknown function. The drdlwf allele is associated …