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Septohippocampal Gabaergic Neurons Mediate The Altered Behaviors Induced By N-Methyl-D-Aspartate Receptor Antagonists., Jingyi Ma, Siew Kian Tai, L Stan Leung

Physiology and Pharmacology Publications

We hypothesize that selective lesion of the septohippocampal GABAergic neurons suppresses the altered behaviors induced by an N-methyl-D-aspartate (NMDA) receptor antagonist, ketamine or MK-801. In addition, we hypothesize that septohippocampal GABAergic neurons generate an atropine-resistant theta rhythm that coexists with an atropine-sensitive theta rhythm in the hippocampus. Infusion of orexin-saporin (ore-SAP) into the medial septal area decreased parvalbumin-immunoreactive (GABAergic) neurons by ~80%, without significantly affecting choline-acetyltransferase-immunoreactive (cholinergic) neurons. The theta rhythm during walking, or the immobility-associated theta induced by pilocarpine, was not different between ore-SAP and sham-lesion rats. Walking theta was, however, more disrupted by atropine sulfate in ore-SAP than …

Synaptic And Systems Memory Consolidation In The Black-Capped Chickadee (Poecile Atricapillus), Matthew Barrett

Electronic Thesis and Dissertation Repository

ABSTRACT

Memory consolidation - the time-dependent stabilization of information- involves two processes: 1) synaptic consolidation and 2) systems consolidation. Synaptic consolidation uses a series of protein synthesis cascades that make lasting changes in the underlying neural architecture of a memory. Systems consolidation involves the reorganization of memory such that, with the passage of time, memory that is initially hippocampus-dependent can be retrieved and activated independent of the hippocampus. Black-capped chickadees (Poecile atricapillus) store and relocate food using hippocampus-dependent spatial memory. In Chapter 2 inhibition of protein synthesis by anisomycin, either 0 and 2 h or 4 and 6 …