Life Sciences Commons^™

Ethical Issues In The Use Of Animals In Biomedical And Psychopharmocological Research, John P. Gluck, Jordan Bell

Experimentation Collection

Rationale: The ethical debate concerning the use of animals in biomedical and pharmacological research continues to be replete with misunderstandings about whether animals have moral standing. Objectives: This article briefly reviews the central ethical positions and their relationship to the basic parameters of research regulation from an international perspective. The issues associated with the validation of animal models will then be discussed. Finally, suggestions for empirical ethics research will be presented. Methods: Recent literature reviews were accessed and analyzed. Results: This review summarizes the pertinent ethical and research literature. Conclusions: In summary, regardless of the ethical perspective one favors, there …

Response Cost In The Treatment Of Lunging In Dogs, Jennifer L. Sobie

Masters Theses

Contemporary professional applied animal behavior management employs a diagnostic and treatment approach for unwanted pet behavior that incorporates ethology-based causal factors. As in behavior therapy for humans, behavioral assessment includes descriptive functional analysis when possible to determine relevant contingency variables. But this information is then considered in the context of an appropriate motivational classification, such as social or prey-directed motivation or fear-motivated, and treatments are designed accordingly. A different view is that behavior can be treated effectively without a presumption of the motivation through analysis of the manifestation of the behavior itself. This study sought to evaluate the efficacy of …

Arkansas Animal Science Department Report 2003, Zelpha B. Johnson, D. Wayne Kellogg

Arkansas Agricultural Experiment Station Research Series

The faculty and staff of the Animal Science Program are pleased to present the sixth edition of the Arkansas Animal Science Report. As with virtually all programs in the country, budget constraints presented serious challenges to teaching, research, and extension programming. However, the faculty and staff responded with innovation, good management, and hard work to maintain a productive program designed to benefit the students of the University and the citizens of the state. We are committed to remaining faithful to our Land-Grant mission. A sincere thank you is owed to Dr. Zelpha Johnson and Dr. Wayne Kellogg for editing this …

Comparison Of Bracket Bond Strength By Total, Self-Etch And Laser Treatment, Kyo Sung Shawn Kim

Loma Linda University Electronic Theses, Dissertations & Projects

Laser etching of enamel surfaces alters the physical and chemical characteristics of the enamel. These changes in characteristics enhance the bonding to enamel. The purpose of this study was to compare the shear and tensile bond strength of Er,Cr:YSGG hydrokinetic laser system (Biolase) with 37% phosphoric acid and self etching primer 30 minutes and 72 hours after bonding. Four different laser power output setting was observed: 1.5W, 2.0W, 2.5W, and 3.0W. Two hundred forty bovine teeth free of defect, caries, and dentin exposure were mounted in acrylic resin and divided into 24 groups of 10 teeth. Sixteen groups of 10 …

A Bond Strength Comparison Of Led And Halogen Light Curing Units, John Richard Kavanagh

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this research was to compare the tensile bond strength of orthodontic flat based buttons bonded to bovine teeth with four commercial light-emitting diode (LED) curing lights and one conventional quartz tungsten halogen (QTH) curing light.

The dental market has recently been introduced to a number of commercially available light-emitting diode (LED) curing lights. Tensile bond strength was evaluated for LED curing lights (Rembrandt® Allegro^TM, Den-Mat Corp, Santa Maria, CA), (LEDemetron, Kerr/Demetron Corp, Danbury, Conn), (Ortholux LED, 3M^TMESPE^TM, St. Paul, MN),and (FLASH-lite 1001, Discus Dental, Culver City, CA) are compared with one …

The Histological Effects Of Mandibular Distraction Osteogenesis On Rabbit Condyles, Eunice Jungmin Hong

Loma Linda University Electronic Theses, Dissertations & Projects

The present study is a histological evaluation of condyles taken from rabbits that underwent either a midline or paramedian distraction osteogenesis procedure on the mandibles. Fifteen rabbits were originally operated on and eight of these fifteen successfully made it through both the distraction osteogenesis procedure and the 1 month holding period that followed. There was one control animal.

In the present study, the condyles from these nine rabbits (1 control, 2 midline distraction osteogenesis, 6 paramedian distraction osteogenesis) were prepared for histological evaluation (18 total). Step serial sections were cut along the coronal plane and the sections from the anterior …

Effects Of Various Hemostatic Agents On Bone, David Daryl Roland

Loma Linda University Electronic Theses, Dissertations & Projects

Previous studies have evaluated the effects of various hemostatic agents on radicular tissues following apical surgery. The purpose of this study was to examine the early osseous responses to seven hemostatic agents under identical conditions in rabbits. Sixteen adult male New Zealand white rabbits were used for this study. Following anesthesia, utilizing a midline submandibular incision, standardized bony defects were prepared on the lateral-superior regions of the mandible. Test materials were placed using standardized volumes and exposure times. Bone wax, Surgicel, Capset, alginate, Cut-Trol, Hemogin-L, and silver nitrate were compared to control sites irrigated with saline. Test materials or controls …

Synovial Fluid Hydrostatic Pressure In The Tmj After Mandibular Advancement In Sus Scrofa, Samuel A. Demirdji

Loma Linda University Electronic Theses, Dissertations & Projects

Mandibular advancement is performed in patients routinely by traditional bilateral sagittal split osteotomy (BSSO) or less commonly by distraction osteogenesis (DO). The influence of mandibular advancement on the temporomandibular joint (TMJ) is well recognized but not fully explored. This study involved the direct measurement of synovial fluid hydrostatic pressure (SFHP) in the TMJ after mandibular advancement by either BSSO or DO in two male mature minipigs, Sus scrofa. Titanium pressure transducers were inserted into the right superior temporomandibular joint spaces of the minipigs and the measurements were displayed on an AC/DC amplifier. The first minipig underwent BSSO, which involved immediate …

Radiation Effects On Dopamine-Mediated Prepulse Inhibition In The C57bl/6 Mouse, Cara Nicole Zuccarelli Miller

Loma Linda University Electronic Theses, Dissertations & Projects

This study examined the effects of proton and gamma radiation on a dopamine-dependent sensory gating mechanism: prepulse inhibition of the startle reflex. The purpose of this research was to describe potential hazards of proton radiation to the central nervous system in long-term space fight and for proton therapy patients. Results from previous research indicate that startle behavior is modified by proton and iron radiation. Forty-eight 10-½ week old, male C57BL/6 mice were used to characterize the optimal parameters for the model (prepulse duration, probe duration, and stimulus-onset-asynchrony). Three hundred and fifty two mice were used to characterize the time course …

Sheep Updates 2003 - Pastures, Ed Barrett-Lennard, Hayley Norman, Robyn Dynes, David Masters, David Henry, Stephen Gherardi, Graham Donald, Asoka Edirisinghe, Chris Oldham, Richard Smith, Joanne Sneddon, Mike Hyder, Andrew Thompson, Kazue Tanaka, Roy Latta, Chris Matthews, Brad Nutt, Angela Loi, Tim Wiley

Sheep Updates

This session covers seven papers from different authors: 1. Pastures for saline land, Ed Barrett-Lennard 1Department of Agriculture, Western Australia, Hayley Norman, Robyn Dynes and David Masters CSIRO Livestock Industries, Centre for Mediterranean Agricultural Research, Floreat Park, 2. Feeding value - the essential link between pastures and animals CSIRO Livestock Industries, Centre for Environmental and Life Sciences 3. ‘Pastures from space’ - how do we do it, how well do we do it and what do producers think about it? Stephen Gherardi Department of Agriculture Western Australia Graham Donald Asoka Edirisinghe Dave Henry CSIRO Livestock Industries Chris Oldham Department of …

Behavioral Evaluation Of The Psychological Welfare And Environmental Requirements Of Agricultural Research Animals: Theory, Measurement, Ethics, And Practical Implications, Lesley A. King

Experimentation Collection

The welfare of agricultural research animals relies not only on measures of good health but also on the presence of positive emotional states and the absence of aversive or unpleasant subjective states such as fear, frustration, or association with pain. Although subjective states are not inherently observable, their interaction with motivational states can be measured through assessment of motivated behavior, which indicates the priority animals place on obtaining or avoiding specific environmental stimuli and thus allows conclusions regarding the impact of housing, husbandry, and experimental procedures on animal welfare. Preference tests and consumer demand models demonstrate that animal choices are …

Developmental Toxicity Of Atrazine And Copper Sulfate Using The Frog Embryo Teratogenesis Assay-Xenopus (Fetax), Misty D. Hamilton

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Science and Technology at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Science by Misty D. Hamilton on June 25, 2003.

Distraction Osteogenesis In Edentulous Alveolar Bone With Rhbmp-2 Enhancement, Liviu F. Eftimie

Loma Linda University Electronic Theses, Dissertations & Projects

Distraction osteogenesis, a unique system of affecting rapid bone healing in fractures, realigning malformed bones, and lengthening congenitally short and traumatically shortened bones has become an increasingly utilized technique for the maxillofacial region. The use of distraction osteogenesis has been described for increasing the height of edentulous mandibular alveolar ridges while concurrently forming new bone within the ridge to allow for adequate reconstruction. A standard protocol for performing distraction osteogenesis in the maxillofacial region has been well documented in the literature. Standard distraction osteogenesis requires an initial surgery to place the distraction osteogenesis device and mobilize the segment to be …

Pain And Distress Associated With Polyclonal Antibody Production: Discussion And Recommendations, The Humane Society Of The United States

ANIMAL RESEARCH

The Humane Society of the United States (HSUS) held a workshop in August 2002 in order to develop recommendations for minimizing pain and distress associated with polyclonal antibody (Pab) production. A small group of experts in the fields of antibody production, animal welfare, in vitro alternatives, and/or regulatory compliance participated in the roundtable discussion. The workshop was a scientifically based meeting, and recommendations were based on the extensive experience of the workshop participants as well as published literature regarding the relevant issues.

Participants recognized that insufficient attention has been paid to animal welfare aspects of Pab production, in part because …

Toxicology And New Social Ethics For Animals, Bernard E. Rollin

Experimentation Collection

The issue of animal treatment has emerged as a major social concern over the past three decades. This ramified in a new ethic for animal treatment that goes beyond concern about cruelty and attempts to eliminate animal pain and suffering, whatever its source. This is evidenced by laws governing animal research in many countries. Insofar as toxicology can entail significant and prolonged animal suffering, it is at loggerheads with this new ethic. Ways are suggested for the toxicological community to put itself in harmony with the ethic and thereby preserve its autonomy.

What It Is To Be A Dog: A Qualitative Method For The Study Of Animals Other Than Humans, Kenneth J. Shapiro

Experimentation Collection

No abstract provided.