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Full-Text Articles in Life Sciences

The Use Of Argumentation In Socio-Scientific Issues: Enhancing Evolutionary Biology Instruction, Heath R. Marchand Aug 2015

The Use Of Argumentation In Socio-Scientific Issues: Enhancing Evolutionary Biology Instruction, Heath R. Marchand

Education and Human Development Master's Theses

With the adoption of the Next Generation Science Standards (NGSS), further emphasis in science education is being placed on preparing students to become more informed voters regarding social, ethical, economic and political topics that affect contemporary society. Parallel to this shift is a stronger emphasis on integrating evolutionary theory as a unifying concept in the biological sciences. Given that evolution is one of the aforementioned topics commonly discussed and debated about in social and political arenas, ensuring that instruction provides students from all backgrounds a comprehensive understanding of its principals is becoming increasingly important in contemporary science education. Chapter II ...


Cell Viability Assessment Using The Alamar Blue Assay: A Comparison Of 2d And 3d Cell Culture Models, Franck Bonnier, Mark Keating, Tomasz P. Wrobel, Katarsyna Majzner, Malgorzata Baranska, Amaya Garcia, Alfonso Blanco, Hugh J. Byrne Feb 2015

Cell Viability Assessment Using The Alamar Blue Assay: A Comparison Of 2d And 3d Cell Culture Models, Franck Bonnier, Mark Keating, Tomasz P. Wrobel, Katarsyna Majzner, Malgorzata Baranska, Amaya Garcia, Alfonso Blanco, Hugh J. Byrne

Articles

Comparisons of 2D and 3D cell culture models in literature have indicated differences in cellular morphology and metabolism, commonly attributed the better representation of in vivo conditions of the latter cell culture environment. Thus, interest in the use of 3D collagen gels for in vitro analysis has been growing. Although comparative studies to date have indicated an enhanced resistance of cells on collagen matrices against different toxicants, in the present study it is demonstrated that non-adapted protocols can lead to misinterpretation of results obtained from classical colorometric dye-based cytotoxic assays. Using the well established Alamar Blue assay, the ...


An Exploration Of The Wheel-Induced Feeding-Suppression, Stephen Benjamin Peckham Jan 2015

An Exploration Of The Wheel-Induced Feeding-Suppression, Stephen Benjamin Peckham

Theses and Dissertations (Comprehensive)

Anorexia nervosa is an enigmatic human condition typified by food-restriction that is often accompanied by extensive exercise. This has been modeled in rats in the wheel-induced feeding-suppression (WIFS) model. In this model, animals are given access to a running-wheel, which induces a volitional drop in food-consumption. Short periods of wheel access have induced a feeding-suppression which is effectively reversed by chlorpromazine administration (Adams et al., 2009). Recent attempts at replicating Adams et al.’s (2009) feeding-suppression have, however, been unsuccessful (Peckham et al., 2013). These attempts raised questions as to whether or not the existing methodology is most effective at ...


Anthropogenic Noise Alters Bat Activity Levels And Echolocation Calls, Jessie P. Bunkley, Christopher J.W. Mcclure, Nathan J. Kleist, Clinton D. Francis, Jesse R. Barber Jan 2015

Anthropogenic Noise Alters Bat Activity Levels And Echolocation Calls, Jessie P. Bunkley, Christopher J.W. Mcclure, Nathan J. Kleist, Clinton D. Francis, Jesse R. Barber

Jesse R. Barber

Negative impacts from anthropogenic noise are well documented for many wildlife taxa. Investigations of the effects of noise on bats however, have not been conducted outside of the laboratory. Bats that hunt arthropods rely on auditory information to forage. Part of this acoustic information can fall within the spectrum of anthropogenic noise, which can potentially interfere with signal reception and processing. Compressor stations associated with natural gas extraction produce broadband noise 24 hours a day, 365 days a year. With over half a million producing gas wells in the U.S. this infrastructure is a major source of noise pollution ...


Anthropogenic Noise Alters Bat Activity Levels And Echolocation Calls, Jessie P. Bunkley, Christopher J.W. Mcclure, Nathan J. Kleist, Clinton D. Francis, Jesse R. Barber Jan 2015

Anthropogenic Noise Alters Bat Activity Levels And Echolocation Calls, Jessie P. Bunkley, Christopher J.W. Mcclure, Nathan J. Kleist, Clinton D. Francis, Jesse R. Barber

Biology Faculty Publications and Presentations

Negative impacts from anthropogenic noise are well documented for many wildlife taxa. Investigations of the effects of noise on bats however, have not been conducted outside of the laboratory. Bats that hunt arthropods rely on auditory information to forage. Part of this acoustic information can fall within the spectrum of anthropogenic noise, which can potentially interfere with signal reception and processing. Compressor stations associated with natural gas extraction produce broadband noise 24 hours a day, 365 days a year. With over half a million producing gas wells in the U.S. this infrastructure is a major source of noise pollution ...


Evaluation Of The Developmental Toxicity Of Lead In The Danio Rerio Body, Nicole M. Roy, Sarah Dewolf, Bruno Carneiro Jan 2015

Evaluation Of The Developmental Toxicity Of Lead In The Danio Rerio Body, Nicole M. Roy, Sarah Dewolf, Bruno Carneiro

Biology Faculty Publications

Lead has been utilized throughout history and is widely distributed and mobilized globally. Although lead in the environment has been somewhat mitigated, the nature of lead and its extensive uses in the past prohibit it from being completely absent from our environment and exposure to lead is still a public health concern. Most studies regarding lead toxicity have focused on the brain. However, little is found in the literature on the effects of lead in other tissues. Here, we utilize the zebrafish model system to investigate effects of lead exposure during early developmental time windows at 24, 48 and 72 ...


An Assessment Of South China Tiger Reintroduction Potential In Hupingshan And Houhe National Nature Reserves, China, Yiyuan Qin, Philip J. Nyhus, Courtney L. Larson, Charles J.W. Carroll, Jeff Muntifering, Thomas D. Dahmer, Lu Jun, Ronald L. Tilson Jan 2015

An Assessment Of South China Tiger Reintroduction Potential In Hupingshan And Houhe National Nature Reserves, China, Yiyuan Qin, Philip J. Nyhus, Courtney L. Larson, Charles J.W. Carroll, Jeff Muntifering, Thomas D. Dahmer, Lu Jun, Ronald L. Tilson

Philip J. Nyhus

Human-caused biodiversity loss is a global problem, large carnivores are particularly threatened, and the tiger (Panthera tigris) is among the world’s most endangered large carnivores. The South China tiger (Panthera tigris amoyensis) is the most critically endangered tiger subspecies and is considered functionally extinct in the wild. The government of China has expressed its intent to reintroduce a small population of South China tigers into a portion of their historic range as part of a larger goal to recover wild tiger populations in China. This would be the world’s first major tiger reintroduction program. A free-ranging population of ...


United In Diversity: Mechanosensitive Ion Channels In Plants, Eric S. Hamilton, Angela M. Schlegel, Elizabeth S. Haswell Jan 2015

United In Diversity: Mechanosensitive Ion Channels In Plants, Eric S. Hamilton, Angela M. Schlegel, Elizabeth S. Haswell

Biology Faculty Publications

Mechanosensitive (MS) ion channels are a common mechanism for perceiving and responding to mechanical force. This class of mechanoreceptors is capable of transducing membrane tension directly into ion flux. In plant systems, MSion channels have been proposed to play a wide array of roles, from the perception of touch and gravity to the osmotic homeostasis of intracellular organelles. Three families of plant MS ion channels have been identified: the MscS-like (MSL), Mid1-complementing activity (MCA), and two-pore potassium (TPK) families. Channels from these families vary widely in structure and function, localize to multiple cellular compartments, and conduct chloride, calcium, and/or ...


Integrating Hands-On Undergraduate Research In An Applied Spatial Science Senior Level Capstone Course, David Kulhavy, Daniel Unger, I-Kuai Hung, David Douglass Jan 2015

Integrating Hands-On Undergraduate Research In An Applied Spatial Science Senior Level Capstone Course, David Kulhavy, Daniel Unger, I-Kuai Hung, David Douglass

Faculty Publications

A senior within a spatial science Ecological Planning capstone course designed an undergraduate research project to increase his spatial science expertise and to assess the hands-on instruction methodology employed within the Bachelor of Science in Spatial Science program at Stephen F Austin State University. The height of 30 building features estimated remotely with LiDAR data, within the Pictometry remotely sensed web-based interface, and in situ with a laser rangefinder were compared to actual building feature height measurements. A comparison of estimated height with actual height indicated that all three estimation techniques tested were unbiased estimators of height. An ANOVA, conducted ...


The Effects Of Lampricide 3-Trifluoromethyl-4-Nitrophenol Toxicity On The Gills Of Larval Sea Lamprey And Non-Target Rainbow Trout And Lake Sturgeon, Lisa A. Sorensen Jan 2015

The Effects Of Lampricide 3-Trifluoromethyl-4-Nitrophenol Toxicity On The Gills Of Larval Sea Lamprey And Non-Target Rainbow Trout And Lake Sturgeon, Lisa A. Sorensen

Theses and Dissertations (Comprehensive)

The pesticide, 3-trifluoromethyl-4-nitrophenol (TFM), is widely used in the Great Lakes to control invasive sea lampreys (Petromyzon marinus) populations, but much about its sub-lethal effects remains unknown. A better understanding of its toxicity is needed to improve TFM effectiveness and to protect non-target organisms from its potential adverse effects. The objectives of this thesis were to test the following two hypotheses: (1) impairment of mitochondrial ATP production by TFM interferes with ATP-dependent ion-uptake by fish, leading to altered electrolyte balance, and (2) perturbations of gill function by TFM are exacerbated in soft, ion poor water (SW; 40 mg CaCO3 ...


Quantifying Land Cover Change Due To Petroleum Exploration And Production In The Haynesville Shale Region Using Remote Sensing, Daniel Unger, I-Kuai Hung, Kenneth W. Farrish, Darinda Dans Jan 2015

Quantifying Land Cover Change Due To Petroleum Exploration And Production In The Haynesville Shale Region Using Remote Sensing, Daniel Unger, I-Kuai Hung, Kenneth W. Farrish, Darinda Dans

Faculty Publications

The Haynesville Shale lies under areas of Louisiana and Texas and is one of the largest gas plays in the U.S. Encompassing approximately 2.9 million ha, this area has been subject to intensive exploration for oil and gas, while over 90% of it has traditionally been used for forestry and agriculture. In order to detect the landscape change in the past few decades, Landsat Thematic Mapper (TM) imagery for six years (1984, 1989, 1994, 2000, 2006, and 2011) was acquired. Unsupervised classifications were performed to classify each image into four cover types: agriculture, forest, well pad, and other ...


Targeted Cancer Therapy Systems: An In Silico Study Of Radiohalogenated Ligands In The Estrogen Receptor And The Synthesis Of A Molecular Toolkit For The Fabrication Of Customizable Nanoparticles, Kelton Kerry Barnsley Jan 2015

Targeted Cancer Therapy Systems: An In Silico Study Of Radiohalogenated Ligands In The Estrogen Receptor And The Synthesis Of A Molecular Toolkit For The Fabrication Of Customizable Nanoparticles, Kelton Kerry Barnsley

Chemistry Master's Theses

Chemotherapy is often limited by off-target toxicity and the development of multi-drug resistance in response to treatment. Strategies which reduce off-target toxicity by passively or actively targeting cancer cells may improve the efficacy of chemotherapy. Herein, two projects relating to targeted therapy are described. In the first project, the binding modes of 1,1-bis(4-hydroxyphenyl)-2-phenylethylenes (THPEs), a class of synthetic estrogens previously developed by our group, in the human estrogen receptor alpha-ligand binding domain were studied using molecular modeling programs YASARA AutoDock and Schrodinger Glide. The results were internally consistent and supported the observation that a bromine or iodine ...


Changes In Corn Residue Quality Throughout The Grazing Period And Effect Of Supplementation Of Calves Grazing Corn Residue, Amanda J. Burken Dec 2014

Changes In Corn Residue Quality Throughout The Grazing Period And Effect Of Supplementation Of Calves Grazing Corn Residue, Amanda J. Burken

Theses and Dissertations in Animal Science

Corn residue is an abundant feed source in Nebraska that can be utilized as an alternative winter feed. Calves were backgrounded on corn residue in order to determine gain and estimate forage intake when supplemented with distillers grains (DGS). Calves grazing the non-irrigated field gained more (1.03 kg/calf daily) when compared to those grazing the irrigated field (0.90 kg/calf daily; P < 0.01). In year 1, a quadratic effect for intake of DGS was present (P < 0.01) while year 2 observed a linear effect for increasing level of DGS (P < 0.01). The nutritional quality of corn residue was evaluated over time in order to determine changes in blade/sheath, cob, husk/shank and stem. Minimal changes in DM of the forage components occurred was grain reached 15.5% moisture. Digestibility of the blade/sheath declined linearly over time (P < 0.01) while the husk remained constant (P = 0.40). Cob digestibility decreased quadratically (P < 0.01) throughout the sampling period with few changes once grain reached 15.5% moisture. Differences observed in the digestibility of the blade/sheath were attributed to the effects of weathering. A third set of trials was conducted to evaluate the effects of by-product supplementation of calves grazing irrigated corn residue and supplemented with DGS or continuous access to lick tubs. The DGS treatment gained more (0.62 kg/calf daily) than the lick tub treatment (0.38 kg/calf daily; P < 0.01). Calves offered DGS consumed more supplement as a percentage of BW (0.52%) when compared with calves offered lick tubs (0.36%; P < 0.01) on a DM basis. Calves supplemented with DGS had a higher supplement efficiency (46.3% to 42.9%, DM basis) although no differences were present between treatments (P = 0.49). When analyzed on an OM basis, however, calves offered lick tubs had a numerically higher supplement efficiency (50.4 ...


Managing Threats To The Urban Forest: From Dutch Elm Disease To Emerald Ash Borer - Learning From Experience, Christopher J. Borman Dec 2014

Managing Threats To The Urban Forest: From Dutch Elm Disease To Emerald Ash Borer - Learning From Experience, Christopher J. Borman

Doctoral Documents from Doctor of Plant Health Program

The urban forest provides important essential services to all municipalities; however, its value is often overlooked. The urban forest contributes to energy savings, environmental benefits, psychological well-being, and social benefits. Managing the urban forest in a sustainable manner is important if we wish to benefit from these services well into the future. Reliable management techniques have been created through previous experiences with pests, and these should be utilized and improved for use on urban forests.

American elm (Ulmus americana L.) was once a major component of the urban forests of North America. In 1927, Dutch elm disease (DED) was introduced ...


A First Survey Of The Centipedes Of Great Smoky Mountains National Park, Joseph Desisto Dec 2014

A First Survey Of The Centipedes Of Great Smoky Mountains National Park, Joseph Desisto

Holster Scholar Projects

No abstract provided.


New Approaches To Corn Silage Use In Beef Cattle Finishing Diets, Dirk Burken Dec 2014

New Approaches To Corn Silage Use In Beef Cattle Finishing Diets, Dirk Burken

Theses and Dissertations in Animal Science

Cattle feeders are considering alternative feedstuffs to replace expensive corn grain and decrease rations costs. Feeding corn silage allows cattle feeders to take advantage of the entire corn plant at a time of maximum quality and tonnage as well as secure substantial quantities of roughage and grain inventory. Distiller’s grains have proven to be economical and are now a commonplace ingredient in feedlot finishing diets. Experiments were conducted to determine the effects of feeding increased concentrations of corn silage in replacement of corn grain in finishing diets containing distillers grains. Feedlot gains and gain:feed ratios were reduced as ...


Noteworthy Collection Of Papaver Rhoeas From Indiana, Jordan M. Marshall Dec 2014

Noteworthy Collection Of Papaver Rhoeas From Indiana, Jordan M. Marshall

Biology Faculty Publications

A new county record of Papaver rhoeas is reported in Allen County, Indiana. Voucher specimens have been deposited in the Indiana University-Purdue University Fort Wayne herbarium. Due to the location, a protected mesic prairie under active management, and the increasing number of county records in Indiana, there may be concern regarding this species collection.


Effect Of Photoperiod On Redox Regulation Of Phenotypic Plasticity And Cellular Growth In Chlorella Vulgaris, Lauren E. Hollis Dec 2014

Effect Of Photoperiod On Redox Regulation Of Phenotypic Plasticity And Cellular Growth In Chlorella Vulgaris, Lauren E. Hollis

University of Western Ontario - Electronic Thesis and Dissertation Repository

Photoautotrophs are predisposed to maintain a balance between light energy absorption with the capacity to consume this energy through metabolism. An imbalance in energy flow may be a consequence of increased light intensity and is sensed as modulation of excitation pressure (EP). Chlorella vulgaris acclimated to continuous high EP exhibits a yellow-green phenotype characterized by reduced chlorophyll content and high chlorophyll a/b ratio with reduced light-harvesting complex abundance relative to the dark green phenotype of low EP-acclimated cultures. Previous studies on acclimation to EP in green algae have been conducted under constant growth light. To determine the role of ...


The Non-Lethal Effects Of Climate Change On The Territoriality Of Lottia Gigantea, Tracey Gunanto, Christina Chavez, Jessica Martinez, William G. Wright Dec 2014

The Non-Lethal Effects Of Climate Change On The Territoriality Of Lottia Gigantea, Tracey Gunanto, Christina Chavez, Jessica Martinez, William G. Wright

Undergraduate Student Research Day Abstracts and Posters

The intertidal zone has been described as ground zero for global warming. Here, the owl limpet, Lottia gigantea, adapted to the cool ocean temperatures, must withstand a few hours of baking sun during day-time low tides. This hardship is predicted to increase in frequency and severity in the future as the globe warms. Our research hypothesized that heat events compromise territorial behavior of L. gigantea. All observations and experiments were performed at Inspiration Point near Newport Beach, California. We measured the natural radiant temperature of tagged limpets during day-time low tides using a field-calibrated infrared “thermogun”. We also experimentally amplified ...


Prostate Field Cancerization -- Thinking Outside The Tumor, Dor Shoshan, Marco Bisoffi Dec 2014

Prostate Field Cancerization -- Thinking Outside The Tumor, Dor Shoshan, Marco Bisoffi

Undergraduate Student Research Day Abstracts and Posters

Prostate field cancerization (or field effect) is characterized by the presence of molecular alterations in histologically normal tissues adjacent to adenocarcinomas. Accordingly, our research indicates deregulated expression of several proteins that define this type of molecular pathology. The scope of the present study was to determine the expression of the key transcription factor and potential marker of field cancerization early growth response 1 (EGR-1) in human prostate tissues derived from prostatectomies and biopsy cores.

EGR-1 was detected by immunofluorescence using a polyclonal anti-human EGR-1 and Alexa Fluor 488-conjugated secondary antibodies. EGR-1 expression was quantitated by determining the pixel count per ...


How The Presence Of Plastic In The North Pacific Gyre Affects The Growth Of Thalassiosira Through Remote Sensing And Laboratory Replication, Jordynn Brennan, Hesham El-Askary Dec 2014

How The Presence Of Plastic In The North Pacific Gyre Affects The Growth Of Thalassiosira Through Remote Sensing And Laboratory Replication, Jordynn Brennan, Hesham El-Askary

Undergraduate Student Research Day Abstracts and Posters

Through the use of remote sensing, we are able to determine the approximate location of the garbage patch in the North Pacific Gyre. Though remote sensing does not penetrate the surface of the ocean, monthly satellite images can be analyzed to determine the rate of growth or rate of decrease of certain parameters, such as atmospheric gases, phytoplankton, and dissolved organic matter. Over the past decade, data from the Goddard Earth Sciences Data and Information Services Center (Giovanni program) has shown a significant increase in dissolved organic matter and chlorophyll a content in the area of the North Pacific Garbage ...


The Effect Of Arsenic Exposure On Feeding Habits Of Hermit Crabs, Natalie Kobayashi, Christopher S. Kim Dec 2014

The Effect Of Arsenic Exposure On Feeding Habits Of Hermit Crabs, Natalie Kobayashi, Christopher S. Kim

Undergraduate Student Research Day Abstracts and Posters

Contaminants that affect marine ecosystems have origins from processes associated with mining and the burning of fossil fuels. This study examines the degree to which arsenic concentrations affect the feeding patterns of hermit crabs to suggest the extent of impact the substance has on a marine ecosystem. Exploring the relationship between the amounts of arsenic exposed to hermit crabs and the amount retained defines the bioavailability of arsenic. The study also aims to correlate the arsenic concentrations in the tissue and the mass of consumed pellet after two weeks of exposure. We hypothesize that when the hermit crabs are exposed ...


Theatre For Development: “The Wanna Be”, Joshua Dominguez Dec 2014

Theatre For Development: “The Wanna Be”, Joshua Dominguez

Undergraduate Student Research Day Abstracts and Posters

The college experience in American culture is a popular topic that is being questioned throughout the media. It is being questioned on a weekly basis in today’s media and brings to light issues that have not been questioned for decades. Some of the main issues such as diversity within institutions, the "Greek System", and sexual assault are all being spotlighted and widely advertised as problems that need focusing on putting an end to. This new era of college students are being challenged to recognize these heavy, yet important issues that are effecting campuses across the nation. Through Theatre for ...


What’S Cookin’ Good Lookin’: The Rise And Phenomena Of The Female Foodie Performer Through Social Media, Alison Weiss Dec 2014

What’S Cookin’ Good Lookin’: The Rise And Phenomena Of The Female Foodie Performer Through Social Media, Alison Weiss

Undergraduate Student Research Day Abstracts and Posters

Once seen in black and white terms as human sustenance or luxury, eating has become not only a hobby, but an obsession. Whereas chefs and cooks were previously regarded as average, behind-the-scenes workers, they have now stepped out from the kitchen and into the spotlight, becoming celebrated public idols – and performers. With images tailored to different demographics right down to their clothing and hairstyles, chefs and cooks no longer merely prepare food: they put on a show. The foodie phenomena has been pioneered by females, largely in part to the parallel-running infatuation with health, fitness, and food trends that make ...


Cognitive Neurosciene And Its Applications To Contemporary Acting Theory, Ryan Stiffelman Dec 2014

Cognitive Neurosciene And Its Applications To Contemporary Acting Theory, Ryan Stiffelman

Undergraduate Student Research Day Abstracts and Posters

I personally believe that anyone can be a performer so long as they have the determination, dedication, and refuse to take no for an answer. There are all kinds of training out there designed to help turn hopeful wannabes into the “stars” that we know them as, however, not every “star” we see has had this kind of training. We often hear of young actors like Jennifer Lawrence hailed for their “natural talent”. Does this mean there’s some kind of birth-right, a specific natural inclination or ability that makes someone a potentially great actor from the start? I will ...


Dancing Through Life: Allosteric Transitions And Structural Analysis Of Hsp70 And Hsp110 Chaperone Proteins, Gabrielle Stetz, Gennady M. Verkhivker Dec 2014

Dancing Through Life: Allosteric Transitions And Structural Analysis Of Hsp70 And Hsp110 Chaperone Proteins, Gabrielle Stetz, Gennady M. Verkhivker

Undergraduate Student Research Day Abstracts and Posters

The molecular chaperone protein Hsp70 is centrally involved in cellular homeostasis by assisting in the folding and degradation of protein substrates. Hsp70 is joined by co-chaperones, such as Hsp110, which contribute to specialized tasks of the Hsp70 complex. Imbalances of this heat shock protein system are believed to be involved with the deregulation of cancer pathways and other human diseases. Better understanding of how these heat shock proteins work at the molecular level, which has been investigated using molecular docking tools, will give more clues about biological function. Simulating the formation and function of Hsp70 based chaperone complexes could provide ...


Comparison Of Tetrad And Degree Of Difference Sensory Testing Methods In Evaluating The Quality Of Flour Tortillas, Kristine Futalan, Criselda Toto, Heather Mcdonald Dec 2014

Comparison Of Tetrad And Degree Of Difference Sensory Testing Methods In Evaluating The Quality Of Flour Tortillas, Kristine Futalan, Criselda Toto, Heather Mcdonald

Undergraduate Student Research Day Abstracts and Posters

The Tetrad test is a forced choice discrimination method that has recently gained popularity in the sensory evaluation of foods. It has demonstrated superiority over the triangle test both in theory and practice with its proven relatively large statistical power. Tetrad does have one potential drawback, the use of a fourth sample that may cause panelist fatigue. There have been many studies comparing the Tetrad method with other difference tests such as triangle, 3- AFC, and 2- AFC however, there has been little research comparing the Tetrad and Degree of Difference test (DOD). This project compared the precision and power ...


Molecular Insights Into Prostate Field Cancerization: Telomere Length, Egr-­‐1 Expression, And Regula:On Of Mic-­‐1, Pdgf-­‐A, And Fas, Emily Frisch, Kristen Gabriel, Marco Bisoffi Dec 2014

Molecular Insights Into Prostate Field Cancerization: Telomere Length, Egr-­‐1 Expression, And Regula:On Of Mic-­‐1, Pdgf-­‐A, And Fas, Emily Frisch, Kristen Gabriel, Marco Bisoffi

Undergraduate Student Research Day Abstracts and Posters

The diagnosis of prostate cancer (adenocarcinoma) relies on screening for elevated prostate-specific antigen (PSA) in blood samples and on digital rectal examination (DRE). With high PSA levels and/or abnormal DRE, physicians recommend a biopsy, which often misses the location of the adenocarcinoma and results in false negatives. Previous studies have shown expression of the key transcription factor early growth response 1 (EGR-1), the pro-survival factor macrophage inhibitor cytokine 1 (MIC-1), and the growth stimulatory platelet derived growth factor A (PDGF-A) to be up-regulated in histologically normal tissues 1 centimeter adjacent to prostate adenocarcinomas. We hypothesize that tumors emerge from ...


Engineered Plga Nanoparticles For Delivery Of Sirna In Mcf-7 Breast Cancer Cells, Sydney Pong, Samit Shah, Vivek Gupta Dec 2014

Engineered Plga Nanoparticles For Delivery Of Sirna In Mcf-7 Breast Cancer Cells, Sydney Pong, Samit Shah, Vivek Gupta

Undergraduate Student Research Day Abstracts and Posters

Small interfering RNAs have been an emerging medical treatment for molecular based diseases as they are capable of gene-specific knockdown. Appropriate and efficient delivery remains one of the biggest challenges in the development of siRNA as an anti-cancer treatment. Nanoparticles containing siRNA were characterized and the efficacy of various peptides in the transfection of the nanoparticles were tested. A gene silencing assay was developed in order to determine the effect of siRNA therapeutics on gene functionality in breast cancer cells.


The Effects Of An Exercise Program On Cardiovascular Risk Factors At A Faith Based University, Annisa R. Albury, Jacob D. Forsythe, Greggory M, Thorpe Dec 2014

The Effects Of An Exercise Program On Cardiovascular Risk Factors At A Faith Based University, Annisa R. Albury, Jacob D. Forsythe, Greggory M, Thorpe

Kinesiology and Allied Health Senior Research Projects

Physical inactivity is a significant risk factor for heart disease, hypertension, stroke, diabetes, and certain types of cancer according to the World Health Organization (WHO, 2013). A simple form of physical activity that improves health and also has a high adherence rate is walking (Dishman, 1994). Walking has been shown to lower fasting blood glucose, decrease total cholesterol, and reduce hypertension when introduced to college faculty and staff as part of a comprehensive wellness program (Haines, 2007). PURPOSE: To determine if a walking program would lower cardiovascular risk factors for faculty and staff who adhere to a faith based values ...