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Full-Text Articles in Life Sciences

Social Sciences, Not Given Dec 2014

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An Analysis Of Mayo Clinic Search Query Logs For Cardiovascular Diseases, Ashutosh Sopan Jadhav, Amit P. Sheth, Jyotishman Pathak Nov 2014

An Analysis Of Mayo Clinic Search Query Logs For Cardiovascular Diseases, Ashutosh Sopan Jadhav, Amit P. Sheth, Jyotishman Pathak

Kno.e.sis Publications

Increasingly, individuals are taking active participation in learning and managing their health by leveraging online resources. Understanding online health information searching behavior can help us to study what health topics users search for and how search queries are formulated. In this work, we analyzed 10 million cardiovascular diseases (CVD) related search queries from MayoClinic.com. We performed semantic analysis on the queries using UMLS MetaMap and analyzed structural and textual properties as well as linguistic characteristics of the queries.


Online Information Searching For Cardiovascular Diseases: An Analysis Of Mayo Clinic Search Query Logs, Ashutosh Sopan Jadhav, Amit P. Sheth, Jyotishman Pathak Nov 2014

Online Information Searching For Cardiovascular Diseases: An Analysis Of Mayo Clinic Search Query Logs, Ashutosh Sopan Jadhav, Amit P. Sheth, Jyotishman Pathak

Kno.e.sis Publications

Since the early 2000’s, Internet usage for health information searching has increased significantly. Studying search queries can help us to understand users “information need” and how do they formulate search queries (“expression of information need”). Although cardiovascular diseases (CVD) affect a large percentage of the population, few studies have investigated how and what users search for CVD. We address this knowledge gap in the community by analyzing a large corpus of 10 million CVD related search queries from MayoClinic.com. Using UMLS MetaMap and UMLS semantic types/concepts, we developed a rule-based approach to categorize the queries into 14 ...


Hundreds Of Scn-Resistant Soybean Varieties Available For 2014, Gregory L. Tylka Oct 2014

Hundreds Of Scn-Resistant Soybean Varieties Available For 2014, Gregory L. Tylka

Integrated Crop Management News

The soybean cyst nematode (SCN) is a serious yield-reducing pathogen of soybeans. It is present in many fields throughout the Midwest, wherever soybeans are grown.

To produce profitable soybean yields in fields infested with SCN, farmers should grow SCN-resistant soybean varieties. SCN-resistant soybeans can produce high yields while keeping SCN population densities from increasing.


Lead Exposure From Aluminum Cookware In Cameroon, Jeffrey D. Weidenhamer, Peter A. Lobunski, Gilbert Kuepouo, Rebecca W. Corbin, Perry Gottesfeld Oct 2014

Lead Exposure From Aluminum Cookware In Cameroon, Jeffrey D. Weidenhamer, Peter A. Lobunski, Gilbert Kuepouo, Rebecca W. Corbin, Perry Gottesfeld

Jeffrey D. Weidenhamer

Blood lead levels have decreased following the removal of lead from gasoline in most of the world. However, numerous recent studies provide evidence that elevated blood lead levels persist in many low and middle-income countries around the world at much higher prevalence than in the more developed countries. One potential source of lead exposure that has not been widely investigated is the leaching of lead from artisanal aluminum cookware, which is commonly used in the developing world. Twenty-nine samples of aluminum cookware and utensils manufactured by local artisans in Cameroon were collected and analyzed for their potential to release lead ...


Dahp Oxime: A Transition State Mimic Inhibitor Of Dahp Synthase, Naresh Balachandran Oct 2014

Dahp Oxime: A Transition State Mimic Inhibitor Of Dahp Synthase, Naresh Balachandran

Open Access Dissertations and Theses

The rise of bacterial infections and increase of antibiotic resistant bacteria has become a major problem in the treatment of bacterial infections. The use and overuse of antibiotics, and the inherent ability of bacteria to adapt to their environment, have lead to the emergence of strains that are resistant to all antibiotics. Ideally, new targets for antibacterial drug therapy would be essential to the virulence of most or all bacteria. That is, antibiotics exploiting these targets would have broad spectrum activity. 3-Deoxy-D-arabinoheptulosonate-7- phosphate (DAHP) synthase could be such a target. This enzyme catalyzes the condensation of erythrose 4-phosphate (E4P) and ...


A Characterization Of The Dynamic Interaction Between The Pro-Apoptotic Protein Bid And The Mitochondrial Outer Membrane, Aisha Shamas-Din Ms. Oct 2014

A Characterization Of The Dynamic Interaction Between The Pro-Apoptotic Protein Bid And The Mitochondrial Outer Membrane, Aisha Shamas-Din Ms.

Open Access Dissertations and Theses

Bcl-2 family of proteins regulate apoptosis at the level of the mitochondrial outer membrane (MOM) through both protein-protein and protein-membrane interactions. While the role of the membrane as the “locus of action” has been recognized, the detailed molecular mechanisms and the consequences of the interactions of Bcl-2 family members with the membrane are yet to be fully understood. The findings presented here focus on the dynamic interactions of Bcl-2 proteins, most notably tBid with the MOM, and their functional significance on mitochondrial outer membrane permeabilization. We show that the activation of tBid is a multi-step process that is regulated by ...


Investigation Of Competence Heterogeneity In Streptococcus Milleri Group Clinical Isolates, Anne-Marie G. Lacroix Oct 2014

Investigation Of Competence Heterogeneity In Streptococcus Milleri Group Clinical Isolates, Anne-Marie G. Lacroix

Open Access Dissertations and Theses

The Streptococcus Milleri/Anginosus group (SMG) includes Streptococcus anginosus, Streptococcus constellatus and Streptococcus intermedius. The SMG is found in healthy individuals but these bacteria are most known clinically for being associated with invasive disease and more recently, airway infections including cystic fibrosis (CF). The SMG like many other streptococci are naturally competent, being able to actively bind, uptake and integrate extracellular DNA. Competence regulation involves a competence-stimulating peptide (CSP) derived from the ComC precursor and a two- component signaling system (a histidine kinase ComD and its response regulator ComE). In this study, I examined the distribution of CSP/ComD sequences ...


The Centennial Of The Smith-Lever Act And Aquaculture Extension, Michael A. Rice Oct 2014

The Centennial Of The Smith-Lever Act And Aquaculture Extension, Michael A. Rice

Michael A Rice

May 8, 2014 marked the centennial of the landmark Smith-Lever Act in the United States that created the Cooperative Extension service at Land Grant Universities nationwide. Major contributors to the 1914 Act were Seaman A. Knapp and Kenyon L. Butterfield. A half century later the Sea Grant College Program was proposed by Athelstan F. Spilhaus expanding Extension programming to the sea. Together these two programs have been a major force in promoting the growth of the aquaculture industry in America.


Silence Is The Loudest Sound, Emma Christian Oct 2014

Silence Is The Loudest Sound, Emma Christian

Honors College

Rhinoceros poaching is an act of killing a rhinoceros in order to take its horn, which is then used for human consumption or for cultural traditions. Both the Asian and the African rhinoceros are targets because of the demand from China, Vietnam, Yemen, and other countries around the world. Traditional Chinese Medicine practice is the main demand for rhinoceros horn and this demand in rhinoceros horn has caused an increase in the black market. Conservation of the rhinoceros is decreasing primarily because the price of rhinoceros horn is more than double the average household income in South Africa, thus making ...


Mindful Eating: Trait And State Mindfulness Predict Healthier Eating Behavior, Christian H. Jordan, Wan Wang, Linda R. Donatoni '10, Brian P. Meier Oct 2014

Mindful Eating: Trait And State Mindfulness Predict Healthier Eating Behavior, Christian H. Jordan, Wan Wang, Linda R. Donatoni '10, Brian P. Meier

Psychology Faculty Publications

Obesity and excess weight are significant societal problems. Mindfulness may encourage healthier weight and eating habits. Across four studies, we found a positive relation between mindfulness and healthier eating. Trait mindfulness was associated with less impulsive eating, reduced calorie consumption, and healthier snack choices. In addition, we found a causal effect of mindfulness on healthier eating. An experimental manipulation of state mindfulness led participants to consume fewer calories in a spontaneous eating task. We also found preliminary evidence that mindfulness affects eating behavior by encouraging attitudinal preferences for healthier foods. Taken together, these results provide strong evidence that mindfulness encourages ...


Epa Targets Nanotechnology: Hi-Ho, Nanosilver, Away?, David L. Wallace, Justin Schenck Oct 2014

Epa Targets Nanotechnology: Hi-Ho, Nanosilver, Away?, David L. Wallace, Justin Schenck

David L Wallace

No abstract provided.


Status Of The Endangered Scotts Valley Spineflower (Polygonaceae) In Coastal Central California, Christopher P. Kofron, Kathleen Lyons Sep 2014

Status Of The Endangered Scotts Valley Spineflower (Polygonaceae) In Coastal Central California, Christopher P. Kofron, Kathleen Lyons

Bulletin of the Southern California Academy of Sciences

Chorizanthe robusta var. hartwegii (Scotts Valley spineflower, Polygonaceae) is a narrow endemic plant restricted to a specialized microhabitat (exposed bedrock in California prairie) in Santa Cruz County, California. This taxon and the nominate variety were listed as endangered under the U.S. Endangered Species Act in 1994. Three occurrences of C. robusta hartwegii exist on four properties in a recently urbanized area at the northern edge of the city of Scotts Valley. Ten of 80 known colonies are now likely extirpated. In 2014 the primary threats are habitat alteration due to adjacent land uses and developments, and invasive plant species ...


From Progesterone In Biopsies To Estimates Of Pregnancy Rates: Large Scale Reproductive Patterns Of Two Sympatric Species Of Common Dolphin, Delphinus Spp. Off California, Usa And Baja, Mexico, Nicholas Marc Kellar, Marisa L. Trego, Susan J. Chivers, Fredrick I. Archer, Wayne L. Perryman Sep 2014

From Progesterone In Biopsies To Estimates Of Pregnancy Rates: Large Scale Reproductive Patterns Of Two Sympatric Species Of Common Dolphin, Delphinus Spp. Off California, Usa And Baja, Mexico, Nicholas Marc Kellar, Marisa L. Trego, Susan J. Chivers, Fredrick I. Archer, Wayne L. Perryman

Bulletin of the Southern California Academy of Sciences

Blubber progesterone levels were measured in biopsy samples and used to predict the pregnancy status of 507 female common dolphins (204 long-beaked common dolphins, Delphinus capensis, and 303 short-beaked common dolphins, D. delphis). Samples were collected in the coastal waters of the eastern North Pacific between central California, USA and the southern end of Baja California, Mexico. The percentage of females pregnant was similar between the two species: 22.1% (n = 45) of D. capensis and 28.1% (n = 85) of D. delphis. For both species we found strong geographic patterns in pregnancy, suggesting that some areas were more conducive ...


Responses Of Small Mammals To Wildfire In A Mixed Conifer Forest In The San Bernardino Mountains, California, Mark I. Borchert Sep 2014

Responses Of Small Mammals To Wildfire In A Mixed Conifer Forest In The San Bernardino Mountains, California, Mark I. Borchert

Bulletin of the Southern California Academy of Sciences

Abstract.—Wildfires are becoming more prevalent in montane conifer forests of the San Bernardino Mountains of southern California. The effects of fire on stand structure and composition of these forests has been extensively studied but there are far fewer studies on how wildfires affect the fauna. For five years after a wildfire in 2007, we live-trapped small mammals in three burn types: unburned, moderate-severity and high-severity. A primary objective of this study was to document the response of the small mammal community to high-severity fire. Pinyon mice were consistently more abundant in unburned forests and declined by 69-76% between unburned ...


Psoroptes Mites And Mule Deer (Odocoileus Hemionus): Additional Notes From The San Bernardino Mountains, California, Vernon C. Bleich Sep 2014

Psoroptes Mites And Mule Deer (Odocoileus Hemionus): Additional Notes From The San Bernardino Mountains, California, Vernon C. Bleich

Bulletin of the Southern California Academy of Sciences

Mites of the genus Psoroptes frequently infest bighorn sheep (Ovis canadensis) in southwestern North America. Although based on a small sample (n = 15), evidence from the San Bernardino Mountains, California, previously suggested that mule deer (Odocoileus hemionus) sympatric with bighorn sheep were not infested with Psoroptes mites and, thus, were not a likely source of mites occurring on bighorn sheep. We examined 34 additional mule deer that were sympatric with bighorn sheep and detected no clinical evidence of Psoroptes infestation, providing additional support for the conclusion of Singer et al. (1997) that mule deer are unlikely sources of mites infesting ...


Natural Egg Sac Clutch Size Of The Brown Widow Spider, Latrodectus Geometricus (Araneae: Theridiidae) In Southern California, Douglas W. R. Danielsen, Daniel E. Clarke, Stephan J. Valle, Amy A. Anselmo, Leonard S. Vincent, Richard S. Vetter Sep 2014

Natural Egg Sac Clutch Size Of The Brown Widow Spider, Latrodectus Geometricus (Araneae: Theridiidae) In Southern California, Douglas W. R. Danielsen, Daniel E. Clarke, Stephan J. Valle, Amy A. Anselmo, Leonard S. Vincent, Richard S. Vetter

Bulletin of the Southern California Academy of Sciences

Abstract. We investigated egg sac clutch size of the brown widow spider, Latrodectus geometricus C. L. Koch, in southern California from June through October 2012 by counting eggs from 214 field collected egg sacs. Clutch size was fairly constant over this five-month period averaging 129.0 ± 51.0 eggs per sac with the only significant monthly difference being more eggs in September than June. Determining the relatively constant egg production for this period contributed knowledge to another project involving application of pesticide to brown widow egg sacs in attempted control of this newly established invasive pest species.


Mapping Regions Of Rnf168 Required For Its Degradation By Icp0, Andrea Cyr, Matthew Weitzman Sep 2014

Mapping Regions Of Rnf168 Required For Its Degradation By Icp0, Andrea Cyr, Matthew Weitzman

e-Research: A Journal of Undergraduate Work

Viruses establish infection by overtaking host cell processes and developing mechanisms that promote viral replication. Herpes simplex virus undergoes lytic and latent cycles of infection throughout the lifespan of its host. The viral genome is transcriptionally silent during latency, but viral proteins are produced upon reactivation. Herpes simplex virus type 1 encodes the ICP0 protein, an E3 ubiquitin ligase required for reactivation from latency of the infectious virus. The immediate-early protein ICP0 regulates the herpes simplex virus by activating viral gene expression thereby initiating lytic infection. Cellular proteins are degraded by ICP0, promoting the virus to enter the lytic cycle ...


Sleep Patterns In Collegiate Dancers, Beth Nicks, Jacque Price Sep 2014

Sleep Patterns In Collegiate Dancers, Beth Nicks, Jacque Price

e-Research: A Journal of Undergraduate Work

As college dance majors, the investigators have witnessed firsthand the effects that sleep and the lack thereof can have on the performance quality of University level dancing. It has been shown that lack of sleep can compromise nearly every physiological process such as memory, coordination, metabolism, and new learning (Wozny 2008). Studies on disruptions of the human circadian rhythms have shown that athletes involved in endeavors where sleep is restricted or totally deprived have severe consequences on behavior and performance. (Edwards 2007). However, the environment of college dance programs is different than athletics due to there being no off season ...


Fossil Baramins On Noah's Ark: The "Amphibians", Marcus R. Ross Sep 2014

Fossil Baramins On Noah's Ark: The "Amphibians", Marcus R. Ross

Marcus R. Ross

Here I provide a compendium of extinct “amphibian” groups, representatives of which may have been carried aboard Noah’s Ark. Following previous work by the Ark Encounter team, I selected the taxonomic rank of family as a first-order proxy for the biblical “kind.” The resulting tabulation places 54 extinct “amphibian” families/kinds on board the Ark. While this number hinges upon taxonomies built upon fossil data (and its inherent shortcomings compared to extant forms), it serves as a reasonable approximation of the number of fossil “amphibians” taken aboard the Ark. When added to previously determined kinds of extant anurans, caudates ...


Annotated Bibliography: Moral & Character Education (1998-2013), Erich Yahner Sep 2014

Annotated Bibliography: Moral & Character Education (1998-2013), Erich Yahner

Humane Education

No abstract provided.


Annotated Bibliography: Attitudes Toward Wildlife And The Environment (1998-2013), Erich Yahner Sep 2014

Annotated Bibliography: Attitudes Toward Wildlife And The Environment (1998-2013), Erich Yahner

Humane Education

No abstract provided.


Annotated Bibliography: Attitudes Toward Animal Research (1998-2013), Erich Yahner Sep 2014

Annotated Bibliography: Attitudes Toward Animal Research (1998-2013), Erich Yahner

Humane Education

No abstract provided.


Treating Cocaine Dependency With Psychopharmacotherapy And Behavioral Therapy, Robyn Liebman Sep 2014

Treating Cocaine Dependency With Psychopharmacotherapy And Behavioral Therapy, Robyn Liebman

e-Research: A Journal of Undergraduate Work

Cocaine is an addictive drug that affects more than 14 million people globally, according to the United Nations. This paper is a conceptual meta-analysis of numerous studies that tested the effects of psychopharmacological therapy along with behavioral therapy in the treatment of cocaine addiction. It is hypothesized that cocaine dependent individuals treated with a combination of psychopharmacological and behavioral therapies will be less likely to use cocaine. Measurements of cocaine use throughout the experiments were generally assessed by urine screenings. Results indicate that there is more evidence that a combination of psychopharmacological and behavioral therapies will reduce cocaine use. There ...


The Effect Of Pomegranate Juice Extract On The Hedgehog Signaling Pathway In Pancreatic Cancer, Veronica Gomez, Talia Shackelford, Autumn Tocchi, Melissa Rowland-Goldsmith, Ph.D. Sep 2014

The Effect Of Pomegranate Juice Extract On The Hedgehog Signaling Pathway In Pancreatic Cancer, Veronica Gomez, Talia Shackelford, Autumn Tocchi, Melissa Rowland-Goldsmith, Ph.D.

e-Research: A Journal of Undergraduate Work

Pancreatic cancer is the fourth leading cause of cancer death in the United States. There have been several reports indicating that phytochemicals in fruits can reduce the risk of cancer due to the anti-oxidant and anti-inflammatory effects of the polyphenols. Our lab has shown that pomegranate juice extract (PJE) has anti-proliferative and pro-apoptotic effects in human pancreatic cancer cells. In the past, we have shown that cells adhere more strongly to the plate when treated with PJE. This observation prompted an investigation of how PJE regulates cell adhesion proteins. Previously, our lab investigated E-cadherin, a cell adhesion protein. Upon activation ...


Effects Of Ocean Acidification On Chlorophyll Content, C. Del Fierro, R. Lloyd, H. El-Askary Sep 2014

Effects Of Ocean Acidification On Chlorophyll Content, C. Del Fierro, R. Lloyd, H. El-Askary

e-Research: A Journal of Undergraduate Work

Airborne pollutants contribute to ocean acidification and hence to the associated chlorophyll content level. Previous work showed that falling aerosols causing ocean acidification would in turn result in bleaching and productivity loss in coral reef builders. Chlorophyll content has been used as a measure of the concentration of the photosynthetic pigment chlorophyll a (the most common "green" chlorophyll) in the ocean. In our work we have monitored the change in chlorophyll content obtained from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor on board Terra/Aqua satellites from 2000-2009 over selected pilot areas. Moreover, we have used the Goddard Chemistry Aerosol ...


Haplotype Variety Analysis Of Human Populations: An Application To Hapmap Data, Michelle Creek, Cyril Rakovski Sep 2014

Haplotype Variety Analysis Of Human Populations: An Application To Hapmap Data, Michelle Creek, Cyril Rakovski

e-Research: A Journal of Undergraduate Work

We undertake a study to investigate the haplotype variety of distinct human populations. We use a natural measure of haplotype variety, the total number of haplotypes (TNH) present that reflects the number of haplotypes with nonzero frequencies estimated from the data at hand for each selection of multiple loci. For the analysis of real human populations, we use the haplotype data of the Denver Chinese, Tuscan Italians, Luhya Kenyans, and Gujarati Indians from release III of the HapMap database. Moreover, we show that the TNH statistic is biased in small sample data scenarios such as the HapMap and implement a ...


On The Ranking Of The Disease Susceptibility Locus In Family-Based Candidate Gene Studies: A Simulation-Based Analysis, Lisa A. Brown, Cyril Rakovski Sep 2014

On The Ranking Of The Disease Susceptibility Locus In Family-Based Candidate Gene Studies: A Simulation-Based Analysis, Lisa A. Brown, Cyril Rakovski

e-Research: A Journal of Undergraduate Work

The ranking of the p-value of the true causal single nucleotide polymorphism in the ordered list of individual SNP p-values is an important factor for achieving success in the ultimate objective of association studies - identifying deleterious genetic variants. Thus, we undertake a study to assess the implications of complex, multimarker correlation structure, sample size and disease models on the ranking of the causal SNP. We carry out an extensive family-based candidate gene simulation study to analyze the position of the disease susceptibility locus in the complete list of individual SNP p-values ordered according to their statistical significance. We simulate data ...


Planning Data Management Education Initiatives: Process, Feedback, And Future Directions, Christopher Eaker Sep 2014

Planning Data Management Education Initiatives: Process, Feedback, And Future Directions, Christopher Eaker

Journal of eScience Librarianship

Educating researchers in sound data management skills is a hot topic in today’s data intensive research world. Librarians across the country and the world are taking the lead in offering this training to their campus research communities. In Fall, 2013, the Data Curation Librarian at the University of Tennessee, Knoxville, held a one-day “Data Management Basics” Workshop geared towards graduate students in engineering and science disciplines based on the New England Collaborative Data Management Curriculum. Students were asked to complete a pre-workshop survey and a series of seven post-module surveys throughout the day. This article discusses the results of ...


Back To School With Celiac, Suad Fahad Alfuraih Sep 2014

Back To School With Celiac, Suad Fahad Alfuraih

Suad Fahad AlFuraih

Back to school with a celiac kid is a big issue for parents, especially in Arabic region where gluten free food and awareness about the disease is so rare