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Multicompartment And Multigeometry Nanoparticle Assembly, Darrin J. Pochan, Jiahua Zhu, Ke Zhang, Karen L. Wooley, Caroline Miesch, Todd S. Emrick
Multicompartment And Multigeometry Nanoparticle Assembly, Darrin J. Pochan, Jiahua Zhu, Ke Zhang, Karen L. Wooley, Caroline Miesch, Todd S. Emrick
Todd S. Emrick
The directed or dynamic assembly of molecular components in solution is a simple and effective strategy to confine materials in desired geometries and length scales. We use a kinetic control strategy with block copolymer blending to construct complex nanoparticles through the demixing of unlike block copolymers within the same nanoscale particle. Successful nanoparticle construction relies on kinetic trapping of unlike block copolymers into the same nanoparticle with solution processing. Not only can we make nanoparticles with multiple internal compartments of a desired size, but we can also make nanoparticles of hybrid geometries (e.g. a blend of cylindrical and spherical geometries). …
Pegylated Polymers For Medicine: From Conjugation To Self-Assembled Systems, Maisie J. Joralemon, Samantha Mcrae, Todd S. Emrick
Pegylated Polymers For Medicine: From Conjugation To Self-Assembled Systems, Maisie J. Joralemon, Samantha Mcrae, Todd S. Emrick
Todd S. Emrick
Synthetic polymers have transformed society in many areas of science and technology, including recent breakthroughs in medicine. Synthetic polymers now offer unique and versatile platforms for drug delivery, as they can be “bio-tailored” for applications as implants, medical devices, and injectable polymer-drug conjugates. However, while several currently used therapeutic proteins and small molecule drugs have benefited from synthetic polymers, the full potential of polymer-based drug delivery platforms has not yet been realized. This review examines both general advantages and specific cases of synthetic polymers in drug delivery, focusing on PEGylation in the context of polymer architecture, self-assembly, and conjugation techniques …