Operations Research, Systems Engineering and Industrial Engineering Commons^™

On Valuing Biopharmaceutical Product Pipelines: An Effectuation Model And Evidence, Mark J. Ahn, Anne S. York, Wei Wu, Yulianto Suharto, Tugrul Unsal Daim

Engineering and Technology Management Faculty Publications and Presentations

New creative approaches are needed to manage emerging biotechnology innovations, regulations, and payor environments to enhance product pipeline productivity, valuation, and risk management. Biopharmaceutical firms must make dynamic resource allocation decisions on their relative levels of internal R&D and external strategic alliances in furthering their pipelines. As the predominant method of using discounted cash flow (DCF) methodologies may lead to chronic underinvestment and performance, we evaluated the integration of traditional DCF with an effectuation model of analysis. Unlike traditional financial models that begin with the end goal of assumed known cash flows and recursively solve for portfolio optimization, the effectuation …

Spare Parts On Demand Using Additive Manufacturing : A Simulation Model For Cost Evaluation., Stefan Jedeck

Electronic Theses and Dissertations

Little is known about the impact of additive manufacturing in the spare part supply chain. A few studies are available, but they focus on specific parts and their applications only. A general model, which can be adapted to different applications, is nonexistent. This dissertation proposes a decision making framework that enables an interested practitioner/manager to decide whether using additive manufacturing to make spare parts on demand is economical when compared to conventional warehousing strategy. The framework consists of two major components: a general discrete event simulation model and a process of designing a wide range of simulation scenarios. The goal …

Characterizing The Effects Of Capillary Flow During Liquid Composite Molding, Michael Ray Morgan

Theses and Dissertations

As the aerospace industry continues to incorporate composites into its aircraft, there will be a need for alternative solutions to the current autoclaving process. Liquid composite molding (LCM) has proven to be a promising alternative, producing parts at faster rates and reduced costs while retaining aerospace grade quality. The most important factor of LCM is controlling the resin flow throughout the fiber reinforcement during infusion, as incomplete filling of fibers is a major quality issue as it results in dry spots or voids. Void formation occurs at the resin flow front due to competition between viscous forces and capillary pressure. …

Integrating Process Mining With Discrete-Event Simulation Modeling, Siyao Liu

Theses and Dissertations

Discrete-event simulation (DES) is an invaluable tool which organizations can use to help better understand, diagnose, and optimize their operational processes. Studies have shown that for the typical DES exercise, the greatest amount of time is spent on developing an accurate model of the process that is to be studied. Process mining, a similar field of study, focuses on using historical data stored in software databases to accurate recreate and analyze business processes. Utilizing process mining techniques to help rapidly develop DES models can drastically reduce the amount of time spent building simulation models, which ultimately will enable organizations to …

The Application Of Gage R&R Analysis In S Six Sigma Case Of Improving And Optimizing An Automotive Die Casting Product’S Measurement System, Qizheng Ren

Masters Theses & Specialist Projects

With the rapid development of automation technology in automotive manufacturing processes, massive and efficient production is a current trend. Therefore, measurement systems with accurate and automated measuring instruments are sought by automotive companies and suppliers. However, the problematic measuring instruments with unreliable accuracy and stability lead to erroneous measurements and wrong quality decisions that cause manufacturers huge profit losses. An effective method called “measurement system analysis” can be applied to define and eliminate erroneous measurements to ensure adequate reliability. An automotive transmission die casting parts supplier called company T was suffering a serious profit loss due to the erroneous measurements …

Mapping Kinematic Functional Abilities Of The Hand To Three Dimensional Shapes For Inclusive Design, Samuel T. Leitkam, Laura Bix, Javier De La Fuente, Tamara Reid Bush

Industrial Technology and Packaging

Loss of hand function can have adverse effects on an individual's ability to maintain independence. The ability to perform daily activities, such as food preparation and medication delivery, is dependent on the hand's ability to grasp and manipulate objects. Therefore, the goal of this research was to demonstrate that three dimensional (3D) modeling of hand function can be used to improve the accessibility of handheld objects for individuals with reduced functionality through informed design. Individual models of hand functionality were created for 43 participants and group models were developed for groups of individuals without (Healthy) and with reduced functionality due …

The Influence Of Cu3(Btc)2 Metal Organic Framework On The Permeability And Perm-Selectivity Of Plla-Mof Mixed Matrix Membranes, Ajay Kathuria, Saleh Al-Ghamdi, Mohamad G. Abiad, Rafael Auras

Industrial Technology and Packaging

Poly(l-lactic acid) (PLLA) - 20% (w/w) and Cu₃(BTC)₂ metal organic framework (MOF) based mixed matrix membranes (MMMs) were fabricated by a vertical corotating twin screw microcompounder followed by an injection molding process. Water vapor, CO_2, O₂, and selected aroma mass transfer properties of PLLA and PLLA MMMs were evaluated. The CO₂/O₂ perm-selectivity of PLLA (α_CO2/O2) MMMs increased from 7.6 to 10.3 with the incorporation of 20% Cu₃(BTC)₂ MOF. Gravimetric permeability studies of trans-2-hexenal performed at 23°C and 50% RH indicated that permeability coefficient of PLLA MMMs …

Creating Quality Metrics For The Capital Facilities Delivery Industry, Kelsey D. Lamb

Graduate Theses and Dissertations

A standard for industry-wide quality metrics, similar to safety metrics, for the capital facilities delivery industry is investigated and developed with the goal to motivate industry-wide adoption of this new quality metric program. A survey of the literature found key differences between capital facilities and other industries, mainly that other industries focus on the quality of the product while capital facilities focus on maintaining the cost and schedule of a project. Creating a framework that can be used across the industry can potentially lead to uniform improvement of quality for the entire industry. Quality is defined for the capital facilities …

Terminological Mediation In Information Technology And Related Fields, Jessica Smith Richards

Theses and Dissertations

Terminological dissonance is created by the inherent ambiguity of natural language and compounded by ontological specialization efforts within fields. Terminological dissonance creates high-risk miscommunications in two key areas: within Information Technology as a singular domain, and also between IT and other fields in interdisciplinary projects. A comprehensive literature review revealed a lack of previous effort to acknowledge or solve problems of terminological dissonance within Information Technology. This research provides a comprehensive overview and definition of the terminology mediation space as it relates to Information Technology and adjacent fields. An analysis and verification of the contents and implementation of the terminology …

Service Dependency Analysis Via Tcp/Udp Port Tracing, John K. Clawson

Theses and Dissertations

Enterprise networks are traditionally mapped via layers two or three, providing a view of what devices are connected to different parts of the network infrastructure. A method was developed to map connections at layer four, providing a view of interconnected systems and services instead of network infrastructure. This data was graphed and displayed in a web application. The information proved beneficial in identifying connections between systems or imbalanced clusters when troubleshooting problems with enterprise applications.

Development Of A Tridimensional Measuring Application For Ipads, Michael Casebolt, Nicolas Kouatli, Jack Mullen

Computer Science and Software Engineering

In today’s fast-paced distribution centers workers and management alike are constantly searching for the quickest and most efficient way to package items for distribution. Even with the advancement of app-oriented solutions to a variety of problems across many industries there is a distinct unmet need in distribution environments for an application capable of increasing the efficiency and accuracy of packaging items. This senior project focused on the development and testing of an application utilizing the Structure Three Dimensional Sensor and a 4th generation iPad to scan an object or group of objects to be packaged and determine the overall dimensions …

Loss On Ignition Using Infrared Heating, Benjamin J. Binoniemi

Masters Theses

The focus of this study is a proof of concept that infrared heating can be used to produce a reliable and rapid method of performing the loss on ignition test. The loss on ignition test is a foundry industry standard test that requires all moisture and volatile organic compounds be vaporized from a sample of foundry sand. The standard test as recommended by the American Foundry Society uses a muffle oven and requires nearly four hours to perform. This new concept performs the same test in approximately ten minutes. The biggest issues with the loss on ignition test are time …

Using Data Envelopment Analysis To Evaluate Technical Training Program For Maintenance Units, Innovative Research Publications Irp India, Nai-Chieh Wei, Tzu-Jou Liao, Chiung-Fen Chang And Shui-Cheung Cham

Innovative Research Publications IRP India

Applying data envelope analysis (DEA), this study focuses on the influences of objectivity and subjectivity on aircraft maintenance supervision evaluation and inspection procedure; the aim is to improve overall logistic operation and training efficiency. Moreover, the results of this analysis will be helpful for making decisions in training, management, capability and competitiveness

Design, Programming, And User-Experience, Kaila G. Manca

Honors Scholar Theses

This thesis is a culmination of my individualized major in Human-Computer Interaction. As such, it showcases my knowledge of design, computer engineering, user-experience research, and puts into practice my background in psychology, com- munications, and neuroscience.

I provided full-service design and development for a web application to be used by the Digital Media and Design Department and their students.This process involved several iterations of user-experience research, testing, concepting, branding and strategy, ideation, and design. It lead to two products.

The first product is full-scale development and optimization of the web appli- cation.The web application adheres to best practices. It was …

A Case Study Of Multiple-Use Finish Electrodes For Die-Sinking Edm, Troy A. Robertson

Masters Theses & Specialist Projects

This study examines the use of one finishing electrode to finish multiple dies without remachining the electrode. The multiple-use electrode finishing experiment in this study addresses technology in the die-forging industry. Methods of manufacturing spherical straight bevel forge gear dies have relied on die-sinking Electrical Discharge Machining (EDM) practices that showed great potential for advancement. The focus of this study is solely on the improvements of electrode use in EDM finishing-processes. The surface finish quality itself is not an area of concern other than maintaining that it does not diminish. The focused concern is maximizing the process by using one …

Modeling New Product Success From Component Measures Of Product Advantage: A Model Utilizing Automated Text Classification And Sentiment Analysis, Ashley Nolen Akerman

Dissertations

What attributes of products are most associated with product success from the perspective of the consumer and how is this association affected by the technology level of the product offering? Creating successful new products is an imperative for long term survival for businesses. Past research has focused on the perspectives of manufacturers to understand product attributes that comprise the construct described as product advantage. This study investigated the components of product advantage from the perspective of the consumer and the significance of each component in explaining variance in product success.

A methodology and two classification toolsets were developed for the …

Design Refinement By Iterative Virtual Experimentation (D.R.I.V.E.): A Methodology To Solving Engineering Design Problems, Charles M. Watson

Morehead State Theses and Dissertations

A Thesis Presented to the Faculty of the College of Science & Technology Morehead State University in Partial Fulfillment of the requirements for the Degree Master of Science by Charles M. “Matt” Watson on April 25, 2015

The Programmatic Generation Of Discrete-Event Simulation Models From Production Tracking Data, Christopher Rand Smith

Theses and Dissertations

Discrete-event simulation can be a useful tool in analyzing complex system dynamics in various industries. However, it is difficult for entry-level users of discrete-event simulation software to both collect the appropriate data to create a model and to actually generate the base-case simulation model. These difficulties decrease the usefulness of simulation software and limit its application in areas in which it could be potentially useful. This research proposes and evaluates a data collection and analysis methodology that would allow for the programmatic generation of simulation models using production tracking data. It uses data collected from a GPS device that follows …

An Affordance-Based Methodology For Package Design, Javier De La Fuente Phd, Stephanie Gustafson, Colleen L. Twomey, Laura Bix

Industrial Technology and Packaging

The term affordance describes an object's utilitarian function or actionable possibilities. Product designers have taken great interest in the concept of affordances because of the bridge they provide relating to design, the interpretation of design and, ultimately, functionality in the hands of consumers. These concepts have been widely studied and applied in the field of psychology but have had limited formal application to packaging design and evaluation. We believe that the concepts related to affordances will reveal novel opportunities for packaging innovation. To catalyse this, presented work had the following objectives: (a) to propose a method by which packaging designers …

Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali

Technology Faculty Publications and Presentations

The dry powder inhaler (DPI) is a popular, effective and convenient drug delivery device for inhalation therapy to treat asthma. However, a large quantity (approximately 54%) of inhaled aerosols deposit in the oropharyngeal region. Deposition in this region is undesirable because it provides minimum therapeutic benefits and has adverse localized or systemic side effects. This study reports a method of examining electrostatic charge effects on deposition of three DPI aerosols (Spiriva^™ Handihaler, Advair Diskus^™, and Pulmicort^™ Turbohaler) in a cadaver-based cast of the human oral-pharyngeal-laryngeal (OPL) regions. Experimental aerosols were generated from the three commercially available …

Intelligent Items Traceability System – Rfid Vs Qr, Masoud Shakiba, Mandeep Singh Jit Singh, Mardina Abdullah

Masoud Shakiba

Nowadays traceability systems are an inseparable part of international business and are essential in manufacturing and supply chain management systems. The advantages of the traceability system are more obvious for products that are exported and those imported from overseas. Traceability is highly important in food management and for products with short expiry. In recent years there have been several investigations and publications on traceability systems criteria especially in the food industry in the US, Europe and Southeast Asia.

Aplicación Del Enfoque Pmi Project Managemet Institute En Planeación Y Desarrollo De Un Envase Para Una Hamburguesa Cruda, Yeny Andrea Caicedo Zambrano, Wilmer Silva Ruiz

Ingeniería de Alimentos

No abstract provided.

Size Effects In Human Visual Inspection For Micro/Meso Scale Parts, Sri Harsha Kavuri

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Visual inspection has been a major method of quality control in conventional manufacturing processes for the last fifty years. Utilizing trained human inspectors to perform this visual inspection has been the most effective means of maintaining quality control. Extensive research has been performed to understand the factors that influence the human inspection process.

In the recent years, there has been a significant emphasis on manufacturing at the smaller end of the size-spectrum such as Micro and Meso scale manufacturing. Quality control at becomes a challenging task due to the extremely small sizes. Several automated visual inspection techniques have been proposed …

Engineered Surface Properties Of Porous Tungsten From Cryogenic Machining, Julius M. Schoop

Theses and Dissertations--Chemical and Materials Engineering

Porous tungsten is used to manufacture dispenser cathodes due to it refractory properties. Surface porosity is critical to functional performance of dispenser cathodes because it allows for an impregnated ceramic compound to migrate to the emitting surface, lowering its work function. Likewise, surface roughness is important because it is necessary to ensure uniform wetting of the molten impregnate during high temperature service. Current industry practice to achieve surface roughness and surface porosity requirements involves the use of a plastic infiltrant during machining. After machining, the infiltrant is baked and the cathode pellet is impregnated. In this context, cryogenic machining is …

Reducing Uncertainty In Technology Selection For Long Life Cycle Engineering Designs, Halil I. Ozdemir, C. Ariel Pinto, Resit Unal, Charles B. Keating, Colin Britcher, Sila Çetinkaya (Ed.), J. K. Ryan (Ed.)

Engineering Management & Systems Engineering Faculty Publications

The best capabilities are usually achieved by having the latest technologies in defense systems. However, including the new, usually immature, technologies in a system design does not always easily result in achieving the capabilities at the right level, at an affordable cost, and in a timely manner. Many programs have suffered from immature technologies as cost overruns, late or no deliveries, and poor performance levels. Another impact of technology selection appears as obsolescence after the deployment of systems, or even before the deployment of the system. As the technologies of a system become obsolete, the cost of maintaining the system …

Color Removal From Pulp Mill Effluent Using Coal Ash Produced From Georgia Power Coal Combustion Plants, Christopher B. Willett

Electronic Theses and Dissertations

Two environmental concerns currently face Georgia: coal fly ash (CFA) waste from coal power plants, and the effluent generated by pulp mills. Pulp mill effluent discolors surface waters into which it is discharged, and has been proven to negatively impact the dissolved oxygen and carbon necessary for aquatic life. The proposed solution is a cost-effective adsorption treatment using an inexpensive but abundantly available waste material: CFA. CFA possesses beneficial properties that allow it to effectively remove contaminants, and is available at significantly reduced cost. The primary research objective was to define treatment parameters that would result in the maximum removal …