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Full-Text Articles in Operations Research, Systems Engineering and Industrial Engineering

In Vitro Cytocompatibility Of Antibacterial Levels Of Polymer Nitric Oxide Release, Rana Gbyli, Christina Zito, Kagya Amoako Jul 2018

In Vitro Cytocompatibility Of Antibacterial Levels Of Polymer Nitric Oxide Release, Rana Gbyli, Christina Zito, Kagya Amoako

Mechanical and Industrial Engineering Faculty Publications

Although the antibacterial property of nitric oxide (NO) has been well documented in gram positive and gram negative bacteria cultures, its cytotoxic effects are not completely clear. To limit potential in vivo cytotoxicity, our group recently investigated the effects of a range of NO fluxes on S. epidermidis and S. aureus to determine a minimum effective NO level. In this study, we report the antibacterial function of this minimum NO level also on gram negative Pseudomonas aeruginosa as well as its cytocompatibility effects on lung and kidney cells. Standardized bacterial cultures were treated with NO releasing PDMS substrates followed by ...


Achieving Totally Local Anticoagulation On Blood Contacting Devices, Rana Gbyli, Anna Mercaldi, Harihara Sundaram, Kagya Amoako Dec 2017

Achieving Totally Local Anticoagulation On Blood Contacting Devices, Rana Gbyli, Anna Mercaldi, Harihara Sundaram, Kagya Amoako

Mechanical and Industrial Engineering Faculty Publications

The recent years have witnessed an increased activity in biocompatibility research aimed at limiting biomaterial-induced blood coagulation. From 2008 to 2016, a total of $36,946,764.00 USD was awarded in grants to 213 research proposals and as large as 50.4% ($18,627,854.00) of that award monies were distributed to 101 proposals over the fiscal years of FY14 to FY16 alone. However, the complexity in blood responses to biomaterials, variability in blood function between individuals and animal species, and differences in medical device application and test setting all continue to pose difficulties in making a breakthrough ...