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Iowa State University

Operational Research

Veterinary Pathology Publications and Papers

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Full-Text Articles in Operations Research, Systems Engineering and Industrial Engineering

A Single Dose Polyanhydride-Based Vaccine Platform Promotes And Maintains Anti-Gnrh Antibody Titers, Robert G. Schaut, Matt T. Brewer, Jesse M. Hostetter, Kriscelle Mendoza, Julia E. Vela-Ramirez, Sean M. Kelly, John K. Jackman, Giuseppe Dell’Anna, Joan M. Howard, Balaji Narasimhan, Wen Zhou, Douglas E. Jones Feb 2018

A Single Dose Polyanhydride-Based Vaccine Platform Promotes And Maintains Anti-Gnrh Antibody Titers, Robert G. Schaut, Matt T. Brewer, Jesse M. Hostetter, Kriscelle Mendoza, Julia E. Vela-Ramirez, Sean M. Kelly, John K. Jackman, Giuseppe Dell’Anna, Joan M. Howard, Balaji Narasimhan, Wen Zhou, Douglas E. Jones

Veterinary Pathology Publications and Papers

Traditionally, vaccination strategies require an initial priming vaccination followed by an antigen boost to generate adequate immunity. Here we describe vaccination against a self-peptide for reproductive sterilization utilizing a three-stage vaccine platform consisting of gonadotropin releasing hormone multiple antigenic peptide (GnRH-MAP) as a soluble injection coupled with subcutaneous administration of polyanhydride-immobilized GnRH-MAP and a cyto-exclusive implant containing GnRH-MAP dendrimer-loaded polyanhydride. This strategy generated and maintained cell-mediated and humoral immunity for up to 41 weeks after a single vaccination in mice with enhanced antibody avidity over time. All intact implants had a grossly visible tissue interface with neovascularization and lymphocytic aggregates ...